BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

182 related articles for article (PubMed ID: 21859302)

  • 1. Drug discovery for neglected tropical diseases at the Sandler Center.
    Robertson SA; Renslo AR
    Future Med Chem; 2011 Aug; 3(10):1279-88. PubMed ID: 21859302
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
    Hargrove TY; Wawrzak Z; Alexander PW; Chaplin JH; Keenan M; Charman SA; Perez CJ; Waterman MR; Chatelain E; Lepesheva GI
    J Biol Chem; 2013 Nov; 288(44):31602-15. PubMed ID: 24047900
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
    Friggeri L; Hargrove TY; Wawrzak Z; Guengerich FP; Lepesheva GI
    J Med Chem; 2019 Nov; 62(22):10391-10401. PubMed ID: 31663733
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.
    Leaver DJ
    Molecules; 2018 Jul; 23(7):. PubMed ID: 30018257
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
    Soeiro Mde N; de Souza EM; da Silva CF; Batista Dda G; Batista MM; Pavão BP; Araújo JS; Aiub CA; da Silva PB; Lionel J; Britto C; Kim K; Sulikowski G; Hargrove TY; Waterman MR; Lepesheva GI
    Antimicrob Agents Chemother; 2013 Sep; 57(9):4151-63. PubMed ID: 23774435
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases.
    Mello JDFRE; Gomes RA; Vital-Fujii DG; Ferreira GM; Trossini GHG
    Chem Biol Drug Des; 2017 Dec; 90(6):1067-1078. PubMed ID: 28547936
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Virtual screening strategies in medicinal chemistry: the state of the art and current challenges.
    Braga RC; Alves VM; Silva AC; Nascimento MN; Silva FC; Liao LM; Andrade CH
    Curr Top Med Chem; 2014; 14(16):1899-912. PubMed ID: 25262801
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development.
    Moraes CB; Giardini MA; Kim H; Franco CH; Araujo-Junior AM; Schenkman S; Chatelain E; Freitas-Junior LH
    Sci Rep; 2014 Apr; 4():4703. PubMed ID: 24736467
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.
    Friggeri L; Hargrove TY; Rachakonda G; Williams AD; Wawrzak Z; Di Santo R; De Vita D; Waterman MR; Tortorella S; Villalta F; Lepesheva GI
    J Med Chem; 2014 Aug; 57(15):6704-17. PubMed ID: 25033013
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.
    Friggeri L; Hargrove TY; Rachakonda G; Blobaum AL; Fisher P; de Oliveira GM; da Silva CF; Soeiro MNC; Nes WD; Lindsley CW; Villalta F; Guengerich FP; Lepesheva GI
    J Med Chem; 2018 Dec; 61(23):10910-10921. PubMed ID: 30451500
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents.
    da Silva Santos-Júnior PF; Schmitt M; de Araújo-Júnior JX; da Silva-Júnior EF
    Curr Top Med Chem; 2021; 21(21):1900-1921. PubMed ID: 33655860
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.
    Hargrove TY; Wawrzak Z; Liu J; Nes WD; Waterman MR; Lepesheva GI
    J Biol Chem; 2011 Jul; 286(30):26838-48. PubMed ID: 21632531
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
    Emami S; Tavangar P; Keighobadi M
    Eur J Med Chem; 2017 Jul; 135():241-259. PubMed ID: 28456033
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases.
    Tavella TA; Cassiano GC; Costa FTM; Sunnerhagen P; Bilsland E
    Adv Protein Chem Struct Biol; 2021; 124():275-309. PubMed ID: 33632468
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
    Guedes-da-Silva FH; Batista DDGJ; Da Silva CF; Pavão BP; Batista MM; Moreira OC; Souza LRQ; Britto C; Rachakonda G; Villalta F; Lepesheva GI; Soeiro MNC
    ACS Infect Dis; 2019 Mar; 5(3):365-371. PubMed ID: 30625275
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.
    Hargrove TY; Wawrzak Z; Liu J; Waterman MR; Nes WD; Lepesheva GI
    J Lipid Res; 2012 Feb; 53(2):311-20. PubMed ID: 22135275
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.
    Hoekstra WJ; Hargrove TY; Wawrzak Z; da Gama Jaen Batista D; da Silva CF; Nefertiti AS; Rachakonda G; Schotzinger RJ; Villalta F; Soeiro Mde N; Lepesheva GI
    Antimicrob Agents Chemother; 2016 Feb; 60(2):1058-66. PubMed ID: 26643331
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
    Friggeri L; Hargrove TY; Wawrzak Z; Blobaum AL; Rachakonda G; Lindsley CW; Villalta F; Nes WD; Botta M; Guengerich FP; Lepesheva GI
    J Med Chem; 2018 Jul; 61(13):5679-5691. PubMed ID: 29894182
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Domain-Swap Dimerization of
    Sharma V; Shing B; Hernandez-Alvarez L; Debnath A; Podust LM
    Mol Pharmacol; 2020 Dec; 98(6):770-780. PubMed ID: 33008918
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and evaluation of benzotriazole derivatives as novel antifungal agents.
    Shah JJ; Khedkar V; Coutinho EC; Mohanraj K
    Bioorg Med Chem Lett; 2015 Sep; 25(17):3730-7. PubMed ID: 26117563
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.