BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

367 related articles for article (PubMed ID: 21859682)

  • 1. High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
    Yu V; Fisch T; Long AM; Tang J; Lee JH; Hierl M; Chen H; Yakowec P; Schwandner R; Emkey R
    J Biomol Screen; 2012 Jan; 17(1):27-38. PubMed ID: 21859682
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.
    Gauthier N; Caron M; Pedro L; Arcand M; Blouin J; Labonté A; Normand C; Paquet V; Rodenbrock A; Roy M; Rouleau N; Beaudet L; Padrós J; Rodriguez-Suarez R
    J Biomol Screen; 2012 Jan; 17(1):49-58. PubMed ID: 21940714
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
    Wissmann M; Yin N; Müller JM; Greschik H; Fodor BD; Jenuwein T; Vogler C; Schneider R; Günther T; Buettner R; Metzger E; Schüle R
    Nat Cell Biol; 2007 Mar; 9(3):347-53. PubMed ID: 17277772
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay.
    Plant M; Dineen T; Cheng A; Long AM; Chen H; Morgenstern KA
    Anal Biochem; 2011 Dec; 419(2):217-27. PubMed ID: 21855527
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry.
    Hutchinson SE; Leveridge MV; Heathcote ML; Francis P; Williams L; Gee M; Munoz-Muriedas J; Leavens B; Shillings A; Jones E; Homes P; Baddeley S; Chung CW; Bridges A; Argyrou A
    J Biomol Screen; 2012 Jan; 17(1):39-48. PubMed ID: 21859681
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TR-FRET cellular assays for interrogating posttranslational modifications of histone H3.
    Machleidt T; Robers MB; Hermanson SB; Dudek JM; Bi K
    J Biomol Screen; 2011 Dec; 16(10):1236-46. PubMed ID: 21972037
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay.
    Wu Q; Lin W; Li ZM; Rankovic Z; White SW; Chen T; Yang J
    STAR Protoc; 2021 Sep; 2(3):100702. PubMed ID: 34485934
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
    Rotili D; Tomassi S; Conte M; Benedetti R; Tortorici M; Ciossani G; Valente S; Marrocco B; Labella D; Novellino E; Mattevi A; Altucci L; Tumber A; Yapp C; King ON; Hopkinson RJ; Kawamura A; Schofield CJ; Mai A
    J Med Chem; 2014 Jan; 57(1):42-55. PubMed ID: 24325601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of cell-active lysine specific demethylase 1-selective inhibitors.
    Ueda R; Suzuki T; Mino K; Tsumoto H; Nakagawa H; Hasegawa M; Sasaki R; Mizukami T; Miyata N
    J Am Chem Soc; 2009 Dec; 131(48):17536-7. PubMed ID: 19950987
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.
    Wigle TJ; Swinger KK; Campbell JE; Scholle MD; Sherrill J; Admirand EA; Boriack-Sjodin PA; Kuntz KW; Chesworth R; Moyer MP; Scott MP; Copeland RA
    J Biomol Screen; 2015 Jul; 20(6):810-20. PubMed ID: 25755264
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
    Kristensen LH; Nielsen AL; Helgstrand C; Lees M; Cloos P; Kastrup JS; Helin K; Olsen L; Gajhede M
    FEBS J; 2012 Jun; 279(11):1905-14. PubMed ID: 22420752
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A sensitive, homogeneous, and high-throughput assay for lysine-specific histone demethylases at the H3K4 site.
    Wang C; Caron M; Burdick D; Kang Z; Auld D; Hill WA; Padrós J; Zhang JH
    Assay Drug Dev Technol; 2012 Apr; 10(2):179-86. PubMed ID: 22192306
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The future therapeutic potential of histone demethylases: A critical analysis.
    Natoli G; Testa G; De Santa F
    Curr Opin Drug Discov Devel; 2009 Sep; 12(5):607-15. PubMed ID: 19736620
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.
    Lohse B; Nielsen AL; Kristensen JB; Helgstrand C; Cloos PA; Olsen L; Gajhede M; Clausen RP; Kristensen JL
    Angew Chem Int Ed Engl; 2011 Sep; 50(39):9100-3. PubMed ID: 21919140
    [No Abstract]   [Full Text] [Related]  

  • 15. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
    Hamada S; Suzuki T; Mino K; Koseki K; Oehme F; Flamme I; Ozasa H; Itoh Y; Ogasawara D; Komaarashi H; Kato A; Tsumoto H; Nakagawa H; Hasegawa M; Sasaki R; Mizukami T; Miyata N
    J Med Chem; 2010 Aug; 53(15):5629-38. PubMed ID: 20684604
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A scintillation proximity assay for histone demethylases.
    Yu W; Eram MS; Hajian T; Szykowska A; Burgess-Brown N; Vedadi M; Brown PJ
    Anal Biochem; 2014 Oct; 463():54-60. PubMed ID: 25010373
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures.
    Ota Y; Kakizawa T; Itoh Y; Suzuki T
    Molecules; 2018 May; 23(5):. PubMed ID: 29734782
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.
    Mulji A; Haslam C; Brown F; Randle R; Karamshi B; Smith J; Eagle R; Munoz-Muriedas J; Taylor J; Sheikh A; Bridges A; Gill K; Jepras R; Smee P; Barker M; Woodrow M; Liddle J; Thomas P; Jones E; Gordon L; Tanner R; Leveridge M; Hutchinson S; Martin M; Brown M; Kruidenier L; Katso R
    J Biomol Screen; 2012 Jan; 17(1):108-20. PubMed ID: 22223398
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).
    Leurs U; Clausen RP; Kristensen JL; Lohse B
    Bioorg Med Chem Lett; 2012 Sep; 22(18):5811-3. PubMed ID: 22917519
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.
    Schmitt ML; Ladwein KI; Carlino L; Schulz-Fincke J; Willmann D; Metzger E; Schilcher P; Imhof A; Schüle R; Sippl W; Jung M
    J Biomol Screen; 2014 Jul; 19(6):973-8. PubMed ID: 24687155
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.