These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

364 related articles for article (PubMed ID: 21859682)

  • 1. High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
    Yu V; Fisch T; Long AM; Tang J; Lee JH; Hierl M; Chen H; Yakowec P; Schwandner R; Emkey R
    J Biomol Screen; 2012 Jan; 17(1):27-38. PubMed ID: 21859682
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.
    Gauthier N; Caron M; Pedro L; Arcand M; Blouin J; Labonté A; Normand C; Paquet V; Rodenbrock A; Roy M; Rouleau N; Beaudet L; Padrós J; Rodriguez-Suarez R
    J Biomol Screen; 2012 Jan; 17(1):49-58. PubMed ID: 21940714
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
    Wissmann M; Yin N; Müller JM; Greschik H; Fodor BD; Jenuwein T; Vogler C; Schneider R; Günther T; Buettner R; Metzger E; Schüle R
    Nat Cell Biol; 2007 Mar; 9(3):347-53. PubMed ID: 17277772
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay.
    Plant M; Dineen T; Cheng A; Long AM; Chen H; Morgenstern KA
    Anal Biochem; 2011 Dec; 419(2):217-27. PubMed ID: 21855527
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry.
    Hutchinson SE; Leveridge MV; Heathcote ML; Francis P; Williams L; Gee M; Munoz-Muriedas J; Leavens B; Shillings A; Jones E; Homes P; Baddeley S; Chung CW; Bridges A; Argyrou A
    J Biomol Screen; 2012 Jan; 17(1):39-48. PubMed ID: 21859681
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TR-FRET cellular assays for interrogating posttranslational modifications of histone H3.
    Machleidt T; Robers MB; Hermanson SB; Dudek JM; Bi K
    J Biomol Screen; 2011 Dec; 16(10):1236-46. PubMed ID: 21972037
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay.
    Wu Q; Lin W; Li ZM; Rankovic Z; White SW; Chen T; Yang J
    STAR Protoc; 2021 Sep; 2(3):100702. PubMed ID: 34485934
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
    Rotili D; Tomassi S; Conte M; Benedetti R; Tortorici M; Ciossani G; Valente S; Marrocco B; Labella D; Novellino E; Mattevi A; Altucci L; Tumber A; Yapp C; King ON; Hopkinson RJ; Kawamura A; Schofield CJ; Mai A
    J Med Chem; 2014 Jan; 57(1):42-55. PubMed ID: 24325601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of cell-active lysine specific demethylase 1-selective inhibitors.
    Ueda R; Suzuki T; Mino K; Tsumoto H; Nakagawa H; Hasegawa M; Sasaki R; Mizukami T; Miyata N
    J Am Chem Soc; 2009 Dec; 131(48):17536-7. PubMed ID: 19950987
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.
    Wigle TJ; Swinger KK; Campbell JE; Scholle MD; Sherrill J; Admirand EA; Boriack-Sjodin PA; Kuntz KW; Chesworth R; Moyer MP; Scott MP; Copeland RA
    J Biomol Screen; 2015 Jul; 20(6):810-20. PubMed ID: 25755264
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
    Kristensen LH; Nielsen AL; Helgstrand C; Lees M; Cloos P; Kastrup JS; Helin K; Olsen L; Gajhede M
    FEBS J; 2012 Jun; 279(11):1905-14. PubMed ID: 22420752
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A sensitive, homogeneous, and high-throughput assay for lysine-specific histone demethylases at the H3K4 site.
    Wang C; Caron M; Burdick D; Kang Z; Auld D; Hill WA; Padrós J; Zhang JH
    Assay Drug Dev Technol; 2012 Apr; 10(2):179-86. PubMed ID: 22192306
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The future therapeutic potential of histone demethylases: A critical analysis.
    Natoli G; Testa G; De Santa F
    Curr Opin Drug Discov Devel; 2009 Sep; 12(5):607-15. PubMed ID: 19736620
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.
    Lohse B; Nielsen AL; Kristensen JB; Helgstrand C; Cloos PA; Olsen L; Gajhede M; Clausen RP; Kristensen JL
    Angew Chem Int Ed Engl; 2011 Sep; 50(39):9100-3. PubMed ID: 21919140
    [No Abstract]   [Full Text] [Related]  

  • 15. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
    Hamada S; Suzuki T; Mino K; Koseki K; Oehme F; Flamme I; Ozasa H; Itoh Y; Ogasawara D; Komaarashi H; Kato A; Tsumoto H; Nakagawa H; Hasegawa M; Sasaki R; Mizukami T; Miyata N
    J Med Chem; 2010 Aug; 53(15):5629-38. PubMed ID: 20684604
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A scintillation proximity assay for histone demethylases.
    Yu W; Eram MS; Hajian T; Szykowska A; Burgess-Brown N; Vedadi M; Brown PJ
    Anal Biochem; 2014 Oct; 463():54-60. PubMed ID: 25010373
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures.
    Ota Y; Kakizawa T; Itoh Y; Suzuki T
    Molecules; 2018 May; 23(5):. PubMed ID: 29734782
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.
    Mulji A; Haslam C; Brown F; Randle R; Karamshi B; Smith J; Eagle R; Munoz-Muriedas J; Taylor J; Sheikh A; Bridges A; Gill K; Jepras R; Smee P; Barker M; Woodrow M; Liddle J; Thomas P; Jones E; Gordon L; Tanner R; Leveridge M; Hutchinson S; Martin M; Brown M; Kruidenier L; Katso R
    J Biomol Screen; 2012 Jan; 17(1):108-20. PubMed ID: 22223398
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).
    Leurs U; Clausen RP; Kristensen JL; Lohse B
    Bioorg Med Chem Lett; 2012 Sep; 22(18):5811-3. PubMed ID: 22917519
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.
    Schmitt ML; Ladwein KI; Carlino L; Schulz-Fincke J; Willmann D; Metzger E; Schilcher P; Imhof A; Schüle R; Sippl W; Jung M
    J Biomol Screen; 2014 Jul; 19(6):973-8. PubMed ID: 24687155
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.