265 related articles for article (PubMed ID: 21859884)
1. Induction of heart valve lesions by small-molecule ALK5 inhibitors.
Anderton MJ; Mellor HR; Bell A; Sadler C; Pass M; Powell S; Steele SJ; Roberts RR; Heier A
Toxicol Pathol; 2011 Oct; 39(6):916-24. PubMed ID: 21859884
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of ALK5 signaling induces physeal dysplasia in rats.
Frazier K; Thomas R; Scicchitano M; Mirabile R; Boyce R; Zimmerman D; Grygielko E; Nold J; DeGouville AC; Huet S; Laping N; Gellibert F
Toxicol Pathol; 2007 Feb; 35(2):284-95. PubMed ID: 17366323
[TBL] [Abstract][Full Text] [Related]
3. Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors.
Ren JX; Li LL; Zou J; Yang L; Yang JL; Yang SY
Eur J Med Chem; 2009 Nov; 44(11):4259-65. PubMed ID: 19640613
[TBL] [Abstract][Full Text] [Related]
4. ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.
Finnson KW; Parker WL; ten Dijke P; Thorikay M; Philip A
J Bone Miner Res; 2008 Jun; 23(6):896-906. PubMed ID: 18333754
[TBL] [Abstract][Full Text] [Related]
5. Expression and function of alternative splice variants of the mouse TGF-beta type I receptor.
Murakami M; Kondo S; Funaba M
Cell Biol Int; 2008 Jul; 32(7):848-54. PubMed ID: 18474439
[TBL] [Abstract][Full Text] [Related]
6. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
Fu K; Corbley MJ; Sun L; Friedman JE; Shan F; Papadatos JL; Costa D; Lutterodt F; Sweigard H; Bowes S; Choi M; Boriack-Sjodin PA; Arduini RM; Sun D; Newman MN; Zhang X; Mead JN; Chuaqui CE; Cheung HK; Zhang X; Cornebise M; Carter MB; Josiah S; Singh J; Lee WC; Gill A; Ling LE
Arterioscler Thromb Vasc Biol; 2008 Apr; 28(4):665-71. PubMed ID: 18202322
[TBL] [Abstract][Full Text] [Related]
7. Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
Van Geest RJ; Klaassen I; Vogels IM; Van Noorden CJ; Schlingemann RO
Invest Ophthalmol Vis Sci; 2010 Apr; 51(4):1857-65. PubMed ID: 19959647
[TBL] [Abstract][Full Text] [Related]
8. Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor.
Huynh QK; Wise SJ; Koch KA; Castonguay LA; Reid BG; Pagratis EE; Koditek D; Glascock CB; Pitts KR; Turner BA; Liu X; Hung M; Han B; Pagratis N
J Biomol Screen; 2011 Aug; 16(7):724-33. PubMed ID: 21521800
[TBL] [Abstract][Full Text] [Related]
9. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.
Schniewind B; Groth S; Sebens Müerköster S; Sipos B; Schäfer H; Kalthoff H; Fändrich F; Ungefroren H
Oncogene; 2007 Jul; 26(33):4850-62. PubMed ID: 17297450
[TBL] [Abstract][Full Text] [Related]
10. Rapid generation of a high quality lead for transforming growth factor-beta (TGF-beta) type I receptor (ALK5).
Goldberg FW; Ward RA; Powell SJ; Debreczeni JE; Norman RA; Roberts NJ; Dishington AP; Gingell HJ; Wickson KF; Roberts AL
J Med Chem; 2009 Dec; 52(23):7901-5. PubMed ID: 19736928
[TBL] [Abstract][Full Text] [Related]
11. Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway.
Yoo YA; Kang MH; Kim JS; Oh SC
Carcinogenesis; 2008 Mar; 29(3):480-90. PubMed ID: 18174246
[TBL] [Abstract][Full Text] [Related]
12. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors.
Goumans MJ; Valdimarsdottir G; Itoh S; Rosendahl A; Sideras P; ten Dijke P
EMBO J; 2002 Apr; 21(7):1743-53. PubMed ID: 11927558
[TBL] [Abstract][Full Text] [Related]
13. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
DaCosta Byfield S; Major C; Laping NJ; Roberts AB
Mol Pharmacol; 2004 Mar; 65(3):744-52. PubMed ID: 14978253
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-β type I receptor kinase.
Amada H; Sekiguchi Y; Ono N; Matsunaga Y; Koami T; Asanuma H; Shiozawa F; Endo M; Ikeda A; Aoki M; Fujimoto N; Wada R; Sato M
Bioorg Med Chem Lett; 2012 Mar; 22(5):2024-9. PubMed ID: 22325945
[TBL] [Abstract][Full Text] [Related]
15. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Blaney Davidson EN; Remst DF; Vitters EL; van Beuningen HM; Blom AB; Goumans MJ; van den Berg WB; van der Kraan PM
J Immunol; 2009 Jun; 182(12):7937-45. PubMed ID: 19494318
[TBL] [Abstract][Full Text] [Related]
16. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling.
König HG; Kögel D; Rami A; Prehn JH
J Cell Biol; 2005 Mar; 168(7):1077-86. PubMed ID: 15781474
[TBL] [Abstract][Full Text] [Related]
17. Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology.
Ling LE; Lee WC
Curr Pharm Biotechnol; 2011 Dec; 12(12):2190-202. PubMed ID: 21619541
[TBL] [Abstract][Full Text] [Related]
18. Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors.
Gellibert F; Fouchet MH; Nguyen VL; Wang R; Krysa G; de Gouville AC; Huet S; Dodic N
Bioorg Med Chem Lett; 2009 Apr; 19(8):2277-81. PubMed ID: 19285388
[TBL] [Abstract][Full Text] [Related]
19. Transforming growth factor-beta induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway.
Haas SL; Fitzner B; Jaster R; Wiercinska E; Gaitantzi H; Jesnowski R; Löhr JM; Singer MV; Dooley S; Breitkopf K
Growth Factors; 2009 Oct; 27(5):289-99. PubMed ID: 19639490
[TBL] [Abstract][Full Text] [Related]
20. Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis.
Medina C; Santos-Martinez MJ; Santana A; Paz-Cabrera MC; Johnston MJ; Mourelle M; Salas A; Guarner F
J Pathol; 2011 Aug; 224(4):461-72. PubMed ID: 21465486
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
