149 related articles for article (PubMed ID: 21861463)
1. Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties.
King AM; Salomé C; Salomé-Grosjean E; De Ryck M; Kaminski R; Valade A; Stables JP; Kohn H
J Med Chem; 2011 Oct; 54(19):6417-31. PubMed ID: 21861463
[TBL] [Abstract][Full Text] [Related]
2. Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
King AM; Salomé C; Dinsmore J; Salomé-Grosjean E; De Ryck M; Kaminski R; Valade A; Kohn H
J Med Chem; 2011 Jul; 54(13):4815-30. PubMed ID: 21639114
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Baruah PK; Dinsmore J; King AM; Salomé C; De Ryck M; Kaminski R; Provins L; Kohn H
Bioorg Med Chem; 2012 Jun; 20(11):3551-64. PubMed ID: 22546207
[TBL] [Abstract][Full Text] [Related]
4. Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide.
King AM; De Ryck M; Kaminski R; Valade A; Stables JP; Kohn H
J Med Chem; 2011 Oct; 54(19):6432-42. PubMed ID: 21861466
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and anticonvulsant activities of N-Benzyl-2-acetamidopropionamide derivatives.
Choi D; Stables JP; Kohn H
J Med Chem; 1996 Apr; 39(9):1907-16. PubMed ID: 8627614
[TBL] [Abstract][Full Text] [Related]
6. N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities.
Béguin C; LeTiran A; Stables JP; Voyksner RD; Kohn H
Bioorg Med Chem; 2004 Jun; 12(11):3079-96. PubMed ID: 15142567
[TBL] [Abstract][Full Text] [Related]
7. The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Morieux P; Salomé C; Park KD; Stables JP; Kohn H
J Med Chem; 2010 Aug; 53(15):5716-26. PubMed ID: 20614888
[TBL] [Abstract][Full Text] [Related]
8. Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
LeTiran A; Stables JP; Kohn H
J Med Chem; 2002 Oct; 45(21):4762-73. PubMed ID: 12361404
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Salomé C; Salomé-Grosjean E; Park KD; Morieux P; Swendiman R; DeMarco E; Stables JP; Kohn H
J Med Chem; 2010 Feb; 53(3):1288-305. PubMed ID: 20041718
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and preliminary evaluation of anticonvulsant activity of some [4-(benzyloxy) benzoyl]- and [4-(benzyloxy) benzyl] aminoalkanol derivatives.
Waszkielewicz AM; Cegła M; Marona H
Acta Pol Pharm; 2007; 64(2):147-57. PubMed ID: 17665864
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones.
Kamiński K; Obniska J
Bioorg Med Chem; 2008 May; 16(9):4921-31. PubMed ID: 18375131
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.
He X; Zhong M; Zhang T; Wu W; Wu Z; Yang J; Xiao Y; Pan Y; Qiu G; Hu X
Eur J Med Chem; 2010 Dec; 45(12):5870-7. PubMed ID: 20947222
[TBL] [Abstract][Full Text] [Related]
13. Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Torregrosa R; Yang XF; Dustrude ET; Cummins TR; Khanna R; Kohn H
Bioorg Med Chem; 2015 Jul; 23(13):3655-66. PubMed ID: 25922183
[TBL] [Abstract][Full Text] [Related]
14. Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Rapacz A; Kamiński K; Obniska J; Koczurkiewicz P; Pękala E; Filipek B
Naunyn Schmiedebergs Arch Pharmacol; 2017 Jun; 390(6):567-579. PubMed ID: 28188357
[TBL] [Abstract][Full Text] [Related]
15. Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents.
Tripathi L; Singh R; Stables JP
Eur J Med Chem; 2011 Feb; 46(2):509-18. PubMed ID: 21167624
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and pharmacological evaluation of alpha-substituted N-benzylamides of gamma-hydroxybutyric acid with potential GABA-ergic activity. Part 6. Search for new anticonvulsant compounds.
Malawska B; Kulig K; Gajda J; Szczeblewski D; Musiał A; Wieckowski K; Maciag D; Stables JP
Acta Pol Pharm; 2007; 64(2):127-37. PubMed ID: 17665862
[TBL] [Abstract][Full Text] [Related]
17. The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent.
Choi D; Stables JP; Kohn H
Bioorg Med Chem; 1996 Dec; 4(12):2105-14. PubMed ID: 9022975
[TBL] [Abstract][Full Text] [Related]
18. Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Librowski T; Kubacka M; Meusel M; Scolari S; Müller CE; Gütschow M
Eur J Pharmacol; 2007 Mar; 559(2-3):138-49. PubMed ID: 17250826
[TBL] [Abstract][Full Text] [Related]
19. Anticonvulsant activity of phenylmethylenehydantoins: a structure-activity relationship study.
Thenmozhiyal JC; Wong PT; Chui WK
J Med Chem; 2004 Mar; 47(6):1527-35. PubMed ID: 14998338
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and anticonvulsant activity of new n-mannich bases derived from 5-cyclopropyl-5-phenyl-hydantoins.
Byrtus H; Obniska J; Czopek A; Kamiński K
Arch Pharm (Weinheim); 2011 Apr; 344(4):231-41. PubMed ID: 21469172
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
