These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

90 related articles for article (PubMed ID: 21863889)

  • 21. Novel functions of the phospholipase D2-Phox homology domain in protein kinase Czeta activation.
    Kim JH; Kim JH; Ohba M; Suh PG; Ryu SH
    Mol Cell Biol; 2005 Apr; 25(8):3194-208. PubMed ID: 15798205
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
    Cohen EE; Lingen MW; Zhu B; Zhu H; Straza MW; Pierce C; Martin LE; Rosner MR
    Cancer Res; 2006 Jun; 66(12):6296-303. PubMed ID: 16778206
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.
    Engel M; Hindie V; Lopez-Garcia LA; Stroba A; Schaeffer F; Adrian I; Imig J; Idrissova L; Nastainczyk W; Zeuzem S; Alzari PM; Hartmann RW; Piiper A; Biondi RM
    EMBO J; 2006 Nov; 25(23):5469-80. PubMed ID: 17110931
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation.
    Nickischer D; Laethem C; Trask OJ; Williams RG; Kandasamy R; Johnston PA; Johnston PA
    Methods Enzymol; 2006; 414():389-418. PubMed ID: 17110204
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic.
    Budas GR; Koyanagi T; Churchill EN; Mochly-Rosen D
    Biochem Soc Trans; 2007 Nov; 35(Pt 5):1021-6. PubMed ID: 17956268
    [TBL] [Abstract][Full Text] [Related]  

  • 26. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
    Jirousek MR; Gillig JR; Gonzalez CM; Heath WF; McDonald JH; Neel DA; Rito CJ; Singh U; Stramm LE; Melikian-Badalian A; Baevsky M; Ballas LM; Hall SE; Winneroski LL; Faul MM
    J Med Chem; 1996 Jul; 39(14):2664-71. PubMed ID: 8709095
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Binding of the Epstein-Barr virus major envelope glycoprotein gp350 results in the upregulation of the TNF-alpha gene expression in monocytic cells via NF-kappaB involving PKC, PI3-K and tyrosine kinases.
    D'Addario M; Ahmad A; Morgan A; Menezes J
    J Mol Biol; 2000 May; 298(5):765-78. PubMed ID: 10801347
    [TBL] [Abstract][Full Text] [Related]  

  • 28. AGC kinases, mechanisms of regulation ‎and innovative drug development.
    Leroux AE; Schulze JO; Biondi RM
    Semin Cancer Biol; 2018 Feb; 48():1-17. PubMed ID: 28591657
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells.
    Sánchez-Valdepeñas C; Punzón C; San-Antonio B; Martin AG; Fresno M
    Cell Signal; 2007 Mar; 19(3):528-37. PubMed ID: 17070014
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
    Xu X; Chen Y; Fu Q; Ni D; Zhang J; Li X; Lu S
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):361-374. PubMed ID: 30734603
    [TBL] [Abstract][Full Text] [Related]  

  • 31. PIF-pocket as a target for C. albicans Pkh selective inhibitors.
    Pastor-Flores D; Schulze JO; Bahí A; Giacometti R; Ferrer-Dalmau J; Passeron S; Engel M; Süss E; Casamayor A; Biondi RM
    ACS Chem Biol; 2013 Oct; 8(10):2283-92. PubMed ID: 23911092
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling.
    Leroux AE; Gross LZF; Sacerdoti M; Biondi RM
    Adv Exp Med Biol; 2019; 1163():279-311. PubMed ID: 31707708
    [TBL] [Abstract][Full Text] [Related]  

  • 33. An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
    Arencibia JM; Fröhner W; Krupa M; Pastor-Flores D; Merker P; Oellerich T; Neimanis S; Schmithals C; Köberle V; Süß E; Zeuzem S; Stark H; Piiper A; Odadzic D; Schulze JO; Biondi RM
    ACS Chem Biol; 2017 Feb; 12(2):564-573. PubMed ID: 28045490
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
    Abdel-Halim M; Darwish SS; ElHady AK; Hoppstädter J; Abadi AH; Hartmann RW; Kiemer AK; Engel M
    Eur J Pharm Sci; 2016 Oct; 93():405-9. PubMed ID: 27516147
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ).
    Abdel-Halim M; Abadi AH; Engel M
    Medchemcomm; 2018 Jun; 9(6):1076-1082. PubMed ID: 30108997
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
    Liu W; Li P; Mei Y
    J Mol Model; 2019 Jun; 25(7):187. PubMed ID: 31197600
    [TBL] [Abstract][Full Text] [Related]  

  • 37. AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
    Arencibia JM; Pastor-Flores D; Bauer AF; Schulze JO; Biondi RM
    Biochim Biophys Acta; 2013 Jul; 1834(7):1302-21. PubMed ID: 23524293
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
    Sadowsky JD; Burlingame MA; Wolan DW; McClendon CL; Jacobson MP; Wells JA
    Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6056-61. PubMed ID: 21430264
    [TBL] [Abstract][Full Text] [Related]  

  • 39. αC helix displacement as a general approach for allosteric modulation of protein kinases.
    Palmieri L; Rastelli G
    Drug Discov Today; 2013 Apr; 18(7-8):407-14. PubMed ID: 23195331
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds.
    Gross LZF; Winkel AF; Galceran F; Schulze JO; Fröhner W; Cämmerer S; Zeuzem S; Engel M; Leroux AE; Biondi RM
    J Biol Chem; 2024 Aug; 300(8):107550. PubMed ID: 39002682
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.