BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 21865319)

  • 1. Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C.
    Schrieber SJ; Hawke RL; Wen Z; Smith PC; Reddy KR; Wahed AS; Belle SH; Afdhal NH; Navarro VJ; Meyers CM; Doo E; Fried MW
    Drug Metab Dispos; 2011 Dec; 39(12):2182-90. PubMed ID: 21865319
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity.
    Schrieber SJ; Wen Z; Vourvahis M; Smith PC; Fried MW; Kashuba AD; Hawke RL
    Drug Metab Dispos; 2008 Sep; 36(9):1909-16. PubMed ID: 18566043
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD.
    Xie Y; Miranda SR; Hoskins JM; Hawke RL
    Molecules; 2017 Jan; 22(1):. PubMed ID: 28098838
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C.
    Hawke RL; Schrieber SJ; Soule TA; Wen Z; Smith PC; Reddy KR; Wahed AS; Belle SH; Afdhal NH; Navarro VJ; Berman J; Liu QY; Doo E; Fried MW;
    J Clin Pharmacol; 2010 Apr; 50(4):434-49. PubMed ID: 19841158
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
    Wen Z; Dumas TE; Schrieber SJ; Hawke RL; Fried MW; Smith PC
    Drug Metab Dispos; 2008 Jan; 36(1):65-72. PubMed ID: 17913795
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
    Zhu HJ; Brinda BJ; Chavin KD; Bernstein HJ; Patrick KS; Markowitz JS
    Drug Metab Dispos; 2013 Sep; 41(9):1679-85. PubMed ID: 23835761
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
    Miranda SR; Lee JK; Brouwer KL; Wen Z; Smith PC; Hawke RL
    Drug Metab Dispos; 2008 Nov; 36(11):2219-26. PubMed ID: 18687803
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions.
    Lynch KD; Montonye ML; Tian DD; Arman T; Oyanna VO; Bechtold BJ; Graf TN; Oberlies NH; Paine MF; Clarke JD
    Phytother Res; 2021 Jun; 35(6):3286-3297. PubMed ID: 33587330
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
    Albassam AA; Frye RF; Markowitz JS
    Chem Biol Interact; 2017 Jun; 271():24-29. PubMed ID: 28457856
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway.
    Martinelli T; Whittaker A; Benedettelli S; Carboni A; Andrzejewska J
    Phytochemistry; 2017 Dec; 144():9-18. PubMed ID: 28863306
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
    Brantley SJ; Oberlies NH; Kroll DJ; Paine MF
    J Pharmacol Exp Ther; 2010 Mar; 332(3):1081-7. PubMed ID: 19934397
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis.
    Wah Kheong C; Nik Mustapha NR; Mahadeva S
    Clin Gastroenterol Hepatol; 2017 Dec; 15(12):1940-1949.e8. PubMed ID: 28419855
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism.
    Bijak M
    Molecules; 2017 Nov; 22(11):. PubMed ID: 29125572
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.
    Li WY; Yu G; Hogan RM; Mohandas R; Frye RF; Gumpricht E; Markowitz JS
    Clin Ther; 2018 Jan; 40(1):103-113.e1. PubMed ID: 29273470
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioavailability of a silybin-phosphatidylcholine complex in dogs.
    Filburn CR; Kettenacker R; Griffin DW
    J Vet Pharmacol Ther; 2007 Apr; 30(2):132-8. PubMed ID: 17348898
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin.
    Tvrdý V; Pourová J; Jirkovský E; Křen V; Valentová K; Mladěnka P
    Med Res Rev; 2021 Jul; 41(4):2195-2246. PubMed ID: 33587317
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
    Abenavoli L; Izzo AA; Milić N; Cicala C; Santini A; Capasso R
    Phytother Res; 2018 Nov; 32(11):2202-2213. PubMed ID: 30080294
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects.
    Barzaghi N; Crema F; Gatti G; Pifferi G; Perucca E
    Eur J Drug Metab Pharmacokinet; 1990; 15(4):333-8. PubMed ID: 2088770
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of hepatoprotective flavonolignans from silymarin.
    Polyak SJ; Morishima C; Lohmann V; Pal S; Lee DY; Liu Y; Graf TN; Oberlies NH
    Proc Natl Acad Sci U S A; 2010 Mar; 107(13):5995-9. PubMed ID: 20231449
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
    Davis-Searles PR; Nakanishi Y; Kim NC; Graf TN; Oberlies NH; Wani MC; Wall ME; Agarwal R; Kroll DJ
    Cancer Res; 2005 May; 65(10):4448-57. PubMed ID: 15899838
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.