BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 21865652)

  • 1. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.
    Kim KY; Stevens MV; Akter MH; Rusk SE; Huang RJ; Cohen A; Noguchi A; Springer D; Bocharov AV; Eggerman TL; Suen DF; Youle RJ; Amar M; Remaley AT; Sack MN
    J Clin Invest; 2011 Sep; 121(9):3701-12. PubMed ID: 21865652
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.
    Nicholls HT; Kowalski G; Kennedy DJ; Risis S; Zaffino LA; Watson N; Kanellakis P; Watt MJ; Bobik A; Bonen A; Febbraio M; Lancaster GI; Febbraio MA
    Diabetes; 2011 Apr; 60(4):1100-10. PubMed ID: 21378177
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance.
    Edmunds LR; Xie B; Mills AM; Huckestein BR; Undamatla R; Murali A; Pangburn MM; Martin J; Sipula I; Kaufman BA; Scott I; Jurczak MJ
    Mol Metab; 2020 Nov; 41():101051. PubMed ID: 32653576
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.
    von Coelln R; Thomas B; Andrabi SA; Lim KL; Savitt JM; Saffary R; Stirling W; Bruno K; Hess EJ; Lee MK; Dawson VL; Dawson TM
    J Neurosci; 2006 Apr; 26(14):3685-96. PubMed ID: 16597723
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis.
    Edmunds LR; Huckestein BR; Kahn M; Zhang D; Chu Y; Zhang Y; Wendell SG; Shulman GI; Jurczak MJ
    Physiol Rep; 2019 Nov; 7(21):e14281. PubMed ID: 31724300
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.
    Avraham E; Rott R; Liani E; Szargel R; Engelender S
    J Biol Chem; 2007 Apr; 282(17):12842-50. PubMed ID: 17327227
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.
    Cha SH; Choi YR; Heo CH; Kang SJ; Joe EH; Jou I; Kim HM; Park SM
    Mol Neurodegener; 2015 Dec; 10():63. PubMed ID: 26627850
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.
    Costa DK; Huckestein BR; Edmunds LR; Petersen MC; Nasiri A; Butrico GM; Abulizi A; Harmon DB; Lu C; Mantell BS; Hartman DJ; Camporez JP; O'Doherty RM; Cline GW; Shulman GI; Jurczak MJ
    Am J Physiol Endocrinol Metab; 2016 Jul; 311(1):E105-16. PubMed ID: 27166280
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes.
    Corsa CAS; Pearson GL; Renberg A; Askar MM; Vozheiko T; MacDougald OA; Soleimanpour SA
    J Biol Chem; 2019 May; 294(18):7296-7307. PubMed ID: 30877201
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
    Shimura H; Schlossmacher MG; Hattori N; Frosch MP; Trockenbacher A; Schneider R; Mizuno Y; Kosik KS; Selkoe DJ
    Science; 2001 Jul; 293(5528):263-9. PubMed ID: 11431533
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.
    Yasuda T; Mochizuki H
    Apoptosis; 2010 Nov; 15(11):1312-21. PubMed ID: 20221696
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.
    Gautier CA; Erpapazoglou Z; Mouton-Liger F; Muriel MP; Cormier F; Bigou S; Duffaure S; Girard M; Foret B; Iannielli A; Broccoli V; Dalle C; Bohl D; Michel PP; Corvol JC; Brice A; Corti O
    Hum Mol Genet; 2016 Jul; 25(14):2972-2984. PubMed ID: 27206984
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.
    Lu XH; Fleming SM; Meurers B; Ackerson LC; Mortazavi F; Lo V; Hernandez D; Sulzer D; Jackson GR; Maidment NT; Chesselet MF; Yang XW
    J Neurosci; 2009 Feb; 29(7):1962-76. PubMed ID: 19228951
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin.
    Im E; Yoo L; Hyun M; Shin WH; Chung KC
    Open Biol; 2016 Aug; 6(8):. PubMed ID: 27534820
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
    Xiong H; Wang D; Chen L; Choo YS; Ma H; Tang C; Xia K; Jiang W; Ronai Z; Zhuang X; Zhang Z
    J Clin Invest; 2009 Mar; 119(3):650-60. PubMed ID: 19229105
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36.
    Abumrad NA; Moore DJ
    J Clin Invest; 2011 Sep; 121(9):3389-92. PubMed ID: 21865651
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.
    Tang W; Thundyil J; Lim GGY; Tng TJW; Yeow SQZ; Nair A; Chai C; Yao TP; Lim KL
    Hum Mol Genet; 2023 Apr; 32(9):1466-1482. PubMed ID: 36519761
    [TBL] [Abstract][Full Text] [Related]  

  • 18. AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
    Wu W; Wang S; Liu Q; Shan T; Wang X; Feng J; Wang Y
    FASEB J; 2020 Apr; 34(4):4852-4869. PubMed ID: 32048347
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].
    Hattori N
    Rinsho Shinkeigaku; 2004; 44(4-5):241-62. PubMed ID: 15287506
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.
    Brahmachari S; Lee S; Kim S; Yuan C; Karuppagounder SS; Ge P; Shi R; Kim EJ; Liu A; Kim D; Quintin S; Jiang H; Kumar M; Yun SP; Kam TI; Mao X; Lee Y; Swing DA; Tessarollo L; Ko HS; Dawson VL; Dawson TM
    Brain; 2019 Aug; 142(8):2380-2401. PubMed ID: 31237944
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.