BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 21866885)

  • 1. Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.
    Cami-Kobeci G; Polgar WE; Khroyan TV; Toll L; Husbands SM
    J Med Chem; 2011 Oct; 54(19):6531-7. PubMed ID: 21866885
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists.
    Khroyan TV; Polgar WE; Jiang F; Zaveri NT; Toll L
    J Pharmacol Exp Ther; 2009 Dec; 331(3):946-53. PubMed ID: 19713488
    [TBL] [Abstract][Full Text] [Related]  

  • 3. C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.
    Cueva JP; Roche C; Ostovar M; Kumar V; Clark MJ; Hillhouse TM; Lewis JW; Traynor JR; Husbands SM
    J Med Chem; 2015 May; 58(10):4242-9. PubMed ID: 25898137
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward.
    Khroyan TV; Polgar WE; Cami-Kobeci G; Husbands SM; Zaveri NT; Toll L
    J Pharmacol Exp Ther; 2011 Mar; 336(3):952-61. PubMed ID: 21177476
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
    Zaveri NT; Journigan VB; Polgar WE
    ACS Chem Neurosci; 2015 Apr; 6(4):646-57. PubMed ID: 25635572
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activities of mixed NOP and mu-opioid receptor ligands.
    Spagnolo B; Calo G; Polgar WE; Jiang F; Olsen CM; Berzetei-Gurske I; Khroyan TV; Husbands SM; Lewis JW; Toll L; Zaveri NT
    Br J Pharmacol; 2008 Feb; 153(3):609-19. PubMed ID: 18059322
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
    Sukhtankar DD; Zaveri NT; Husbands SM; Ko MC
    J Pharmacol Exp Ther; 2013 Jul; 346(1):11-22. PubMed ID: 23652222
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice.
    Khroyan TV; Wu J; Polgar WE; Cami-Kobeci G; Fotaki N; Husbands SM; Toll L
    Br J Pharmacol; 2015 Jan; 172(2):668-80. PubMed ID: 24903063
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
    Cremeans CM; Gruley E; Kyle DJ; Ko MC
    J Pharmacol Exp Ther; 2012 Oct; 343(1):72-81. PubMed ID: 22743574
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.
    Brown SM; Holtzman M; Kim T; Kharasch ED
    Anesthesiology; 2011 Dec; 115(6):1251-60. PubMed ID: 22037640
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors.
    Puls K; Schmidhammer H; Wolber G; Spetea M
    Molecules; 2022 Jan; 27(3):. PubMed ID: 35164182
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.
    Seki T; Awamura S; Kimura C; Ide S; Sakano K; Minami M; Nagase H; Satoh M
    Eur J Pharmacol; 1999 Jul; 376(1-2):159-67. PubMed ID: 10440101
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.
    Kallupi M; Shen Q; de Guglielmo G; Yasuda D; Journigan VB; Zaveri NT; Ciccocioppo R
    Addict Biol; 2018 Mar; 23(2):585-595. PubMed ID: 28635181
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
    Flynn SM; Epperly PM; Davenport AT; Cami-Kobeci G; Husbands SM; Ko MC; Czoty PW
    Neuropsychopharmacology; 2019 Jul; 44(8):1476-1484. PubMed ID: 30970376
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
    Journigan VB; Polgar WE; Khroyan TV; Zaveri NT
    Bioorg Med Chem; 2014 Apr; 22(8):2508-16. PubMed ID: 24657054
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor.
    Bloms-Funke P; Gillen C; Schuettler AJ; Wnendt S
    Peptides; 2000 Jul; 21(7):1141-6. PubMed ID: 10998549
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.
    Zaveri NT; Jiang F; Olsen C; Polgar WE; Toll L
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3308-13. PubMed ID: 23623415
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505).
    Dietis N; McDonald J; Molinari S; Calo G; Guerrini R; Rowbotham DJ; Lambert DG
    Br J Anaesth; 2012 Feb; 108(2):262-70. PubMed ID: 22194444
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.
    Kumar V; Ridzwan IE; Grivas K; Lewis JW; Clark MJ; Meurice C; Jimenez-Gomez C; Pogozheva I; Mosberg H; Traynor JR; Husbands SM
    J Med Chem; 2014 May; 57(10):4049-57. PubMed ID: 24761755
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group.
    Traynor JR; Guo L; Coop A; Lewis JW; Woods JH
    J Pharmacol Exp Ther; 1999 Dec; 291(3):1093-9. PubMed ID: 10565829
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.