BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 21873056)

  • 1. Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
    Mohamed T; Yeung JC; Rao PP
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5881-7. PubMed ID: 21873056
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.
    Mohamed T; Zhao X; Habib LK; Yang J; Rao PP
    Bioorg Med Chem; 2011 Apr; 19(7):2269-81. PubMed ID: 21429752
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.
    Catto M; Berezin AA; Lo Re D; Loizou G; Demetriades M; De Stradis A; Campagna F; Koutentis PA; Carotti A
    Eur J Med Chem; 2012 Dec; 58():84-97. PubMed ID: 23108363
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.
    Mohamed T; Rao PP
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3606-9. PubMed ID: 20472431
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.
    Yan JW; Li YP; Ye WJ; Chen SB; Hou JQ; Tan JH; Ou TM; Li D; Gu LQ; Huang ZS
    Bioorg Med Chem; 2012 Apr; 20(8):2527-34. PubMed ID: 22444876
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.
    Osman W; Mohamed T; Sit VM; Vasefi MS; Beazely MA; Rao PP
    Chem Biol Drug Des; 2016 Nov; 88(5):710-723. PubMed ID: 27282589
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.
    Shan WJ; Huang L; Zhou Q; Meng FC; Li XS
    Eur J Med Chem; 2011 Dec; 46(12):5885-93. PubMed ID: 22019228
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.
    Rouleau J; Iorga BI; Guillou C
    Eur J Med Chem; 2011 Jun; 46(6):2193-205. PubMed ID: 21435752
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
    Kwon YE; Park JY; No KT; Shin JH; Lee SK; Eun JS; Yang JH; Shin TY; Kim DK; Chae BS; Leem JY; Kim KH
    Bioorg Med Chem; 2007 Oct; 15(20):6596-607. PubMed ID: 17681794
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.
    Luo W; Li YP; He Y; Huang SL; Tan JH; Ou TM; Li D; Gu LQ; Huang ZS
    Bioorg Med Chem; 2011 Jan; 19(2):763-70. PubMed ID: 21211982
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
    Luo W; Li YP; He Y; Huang SL; Li D; Gu LQ; Huang ZS
    Eur J Med Chem; 2011 Jun; 46(6):2609-16. PubMed ID: 21497959
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
    Samadi A; de los Ríos C; Bolea I; Chioua M; Iriepa I; Moraleda I; Bartolini M; Andrisano V; Gálvez E; Valderas C; Unzeta M; Marco-Contelles J
    Eur J Med Chem; 2012 Jun; 52():251-62. PubMed ID: 22503231
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.
    Mohamed T; Yeung JC; Vasefi MS; Beazely MA; Rao PP
    Bioorg Med Chem Lett; 2012 Jul; 22(14):4707-12. PubMed ID: 22704921
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
    J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.
    Shi A; Huang L; Lu C; He F; Li X
    Bioorg Med Chem; 2011 Apr; 19(7):2298-305. PubMed ID: 21397508
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors.
    Ignasik M; Bajda M; Guzior N; Prinz M; Holzgrabe U; Malawska B
    Arch Pharm (Weinheim); 2012 Jul; 345(7):509-16. PubMed ID: 22467516
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    Tang H; Zhao LZ; Zhao HT; Huang SL; Zhong SM; Qin JK; Chen ZF; Huang ZS; Liang H
    Eur J Med Chem; 2011 Oct; 46(10):4970-9. PubMed ID: 21871694
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Belluti F; Bartolini M; Bottegoni G; Bisi A; Cavalli A; Andrisano V; Rampa A
    Eur J Med Chem; 2011 May; 46(5):1682-93. PubMed ID: 21397996
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.
    Li YP; Ning FX; Yang MB; Li YC; Nie MH; Ou TM; Tan JH; Huang SL; Li D; Gu LQ; Huang ZS
    Eur J Med Chem; 2011 May; 46(5):1572-81. PubMed ID: 21367493
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS; Wang XB; Li JY; Yang L; Kong LY
    Eur J Med Chem; 2013 Jun; 64():540-53. PubMed ID: 23685572
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.