These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
238 related articles for article (PubMed ID: 21880827)
1. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Alvarez-Curto E; Prihandoko R; Tautermann CS; Zwier JM; Pediani JD; Lohse MJ; Hoffmann C; Tobin AB; Milligan G Mol Pharmacol; 2011 Dec; 80(6):1033-46. PubMed ID: 21880827 [TBL] [Abstract][Full Text] [Related]
2. Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET. Alvarez-Curto E; Ward RJ; Pediani JD; Milligan G J Biol Chem; 2010 Jul; 285(30):23318-30. PubMed ID: 20489201 [TBL] [Abstract][Full Text] [Related]
3. The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system. Bradley SJ; Tobin AB; Prihandoko R Neuropharmacology; 2018 Jul; 136(Pt C):421-426. PubMed ID: 29191752 [TBL] [Abstract][Full Text] [Related]
4. Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers. Aslanoglou D; Alvarez-Curto E; Marsango S; Milligan G J Biol Chem; 2015 Jun; 290(23):14785-96. PubMed ID: 25918156 [TBL] [Abstract][Full Text] [Related]
5. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. Chen X; Choo H; Huang XP; Yang X; Stone O; Roth BL; Jin J ACS Chem Neurosci; 2015 Mar; 6(3):476-84. PubMed ID: 25587888 [TBL] [Abstract][Full Text] [Related]
6. Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor. Nakajima K; Wess J Mol Pharmacol; 2012 Oct; 82(4):575-82. PubMed ID: 22821234 [TBL] [Abstract][Full Text] [Related]
7. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. Hudson BD; Christiansen E; Tikhonova IG; Grundmann M; Kostenis E; Adams DR; Ulven T; Milligan G FASEB J; 2012 Dec; 26(12):4951-65. PubMed ID: 22919070 [TBL] [Abstract][Full Text] [Related]
8. A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL). Bruysters M; Jongejan A; Akdemir A; Bakker RA; Leurs R J Biol Chem; 2005 Oct; 280(41):34741-6. PubMed ID: 16027157 [TBL] [Abstract][Full Text] [Related]
9. Ligand specific up-regulation of a Renilla reniformis luciferase-tagged, structurally unstable muscarinic M3 chimeric G protein-coupled receptor. Zeng FY; McLean AJ; Milligan G; Lerner M; Chalmers DT; Behan DP Mol Pharmacol; 2003 Dec; 64(6):1474-84. PubMed ID: 14645678 [TBL] [Abstract][Full Text] [Related]
10. Chemogenetics a robust approach to pharmacology and gene therapy. Keifer O; Kambara K; Lau A; Makinson S; Bertrand D Biochem Pharmacol; 2020 May; 175():113889. PubMed ID: 32119836 [TBL] [Abstract][Full Text] [Related]
11. A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). Claeysen S; Joubert L; Sebben M; Bockaert J; Dumuis A J Biol Chem; 2003 Jan; 278(2):699-702. PubMed ID: 12441358 [TBL] [Abstract][Full Text] [Related]
12. Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Xu TR; Ward RJ; Pediani JD; Milligan G J Biol Chem; 2012 Apr; 287(18):14937-49. PubMed ID: 22389503 [TBL] [Abstract][Full Text] [Related]
13. Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine. Tschammer N; Dörfler M; Hübner H; Gmeiner P ACS Chem Neurosci; 2010 Jan; 1(1):25-35. PubMed ID: 22778805 [TBL] [Abstract][Full Text] [Related]
14. Controlling signaling with a specifically designed Gi-coupled receptor. Coward P; Wada HG; Falk MS; Chan SD; Meng F; Akil H; Conklin BR Proc Natl Acad Sci U S A; 1998 Jan; 95(1):352-7. PubMed ID: 9419379 [TBL] [Abstract][Full Text] [Related]
16. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Armbruster BN; Li X; Pausch MH; Herlitze S; Roth BL Proc Natl Acad Sci U S A; 2007 Mar; 104(12):5163-8. PubMed ID: 17360345 [TBL] [Abstract][Full Text] [Related]
17. Allosteric modulation of a chemogenetically modified G protein-coupled receptor. Abdul-Ridha A; Lane JR; Sexton PM; Canals M; Christopoulos A Mol Pharmacol; 2013 Feb; 83(2):521-30. PubMed ID: 23197649 [TBL] [Abstract][Full Text] [Related]
18. FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists. Markovic D; Holdich J; Al-Sabah S; Mistry R; Krasel C; Mahaut-Smith MP; Challiss RA PLoS One; 2012; 7(1):e29946. PubMed ID: 22272263 [TBL] [Abstract][Full Text] [Related]
19. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Nawaratne V; Leach K; Suratman N; Loiacono RE; Felder CC; Armbruster BN; Roth BL; Sexton PM; Christopoulos A Mol Pharmacol; 2008 Oct; 74(4):1119-31. PubMed ID: 18628403 [TBL] [Abstract][Full Text] [Related]
20. Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Nichols CD; Roth BL Front Mol Neurosci; 2009; 2():16. PubMed ID: 19893765 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]