BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 21886784)

  • 1. Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.
    Koyanagi M; Asahara S; Matsuda T; Hashimoto N; Shigeyama Y; Shibutani Y; Kanno A; Fuchita M; Mikami T; Hosooka T; Inoue H; Matsumoto M; Koike M; Uchiyama Y; Noda T; Seino S; Kasuga M; Kido Y
    PLoS One; 2011; 6(8):e23238. PubMed ID: 21886784
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
    Rachdi L; Balcazar N; Osorio-Duque F; Elghazi L; Weiss A; Gould A; Chang-Chen KJ; Gambello MJ; Bernal-Mizrachi E
    Proc Natl Acad Sci U S A; 2008 Jul; 105(27):9250-5. PubMed ID: 18587048
    [TBL] [Abstract][Full Text] [Related]  

  • 3. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.
    Taneike M; Nishida K; Omiya S; Zarrinpashneh E; Misaka T; Kitazume-Taneike R; Austin R; Takaoka M; Yamaguchi O; Gambello MJ; Shah AM; Otsu K
    PLoS One; 2016; 11(3):e0152628. PubMed ID: 27023784
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
    Zhang HH; Huang J; Düvel K; Boback B; Wu S; Squillace RM; Wu CL; Manning BD
    PLoS One; 2009 Jul; 4(7):e6189. PubMed ID: 19593385
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tissue-specific ablation of Tsc1 in pancreatic beta-cells.
    Mori H; Guan KL
    Methods Mol Biol; 2012; 821():407-19. PubMed ID: 22125081
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.
    Bartolomé A; Kimura-Koyanagi M; Asahara S; Guillén C; Inoue H; Teruyama K; Shimizu S; Kanno A; García-Aguilar A; Koike M; Uchiyama Y; Benito M; Noda T; Kido Y
    Diabetes; 2014 Sep; 63(9):2996-3008. PubMed ID: 24740570
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice.
    Shigeyama Y; Kobayashi T; Kido Y; Hashimoto N; Asahara S; Matsuda T; Takeda A; Inoue T; Shibutani Y; Koyanagi M; Uchida T; Inoue M; Hino O; Kasuga M; Noda T
    Mol Cell Biol; 2008 May; 28(9):2971-9. PubMed ID: 18316403
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.
    Kenerson HL; Yeh MM; Yeung RS
    PLoS One; 2011 Mar; 6(3):e18075. PubMed ID: 21479224
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells.
    Lee PS; Tsang SW; Moses MA; Trayes-Gibson Z; Hsiao LL; Jensen R; Squillace R; Kwiatkowski DJ
    Am J Respir Cell Mol Biol; 2010 Feb; 42(2):227-34. PubMed ID: 19395678
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.
    Bachar E; Ariav Y; Ketzinel-Gilad M; Cerasi E; Kaiser N; Leibowitz G
    PLoS One; 2009; 4(3):e4954. PubMed ID: 19305497
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
    Malhowski AJ; Hira H; Bashiruddin S; Warburton R; Goto J; Robert B; Kwiatkowski DJ; Finlay GA
    Hum Mol Genet; 2011 Apr; 20(7):1290-305. PubMed ID: 21212099
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fetal brain mTOR signaling activation in tuberous sclerosis complex.
    Tsai V; Parker WE; Orlova KA; Baybis M; Chi AW; Berg BD; Birnbaum JF; Estevez J; Okochi K; Sarnat HB; Flores-Sarnat L; Aronica E; Crino PB
    Cereb Cortex; 2014 Feb; 24(2):315-27. PubMed ID: 23081885
    [TBL] [Abstract][Full Text] [Related]  

  • 13. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
    Bhaskar PT; Nogueira V; Patra KC; Jeon SM; Park Y; Robey RB; Hay N
    Mol Cell Biol; 2009 Sep; 29(18):5136-47. PubMed ID: 19620286
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status.
    Marqués P; Burillo J; González-Blanco C; Jiménez B; García G; García-Aguilar A; Iglesias-Fortes S; Lockwood Á; Guillén C
    Sci Rep; 2024 May; 14(1):12521. PubMed ID: 38822085
    [TBL] [Abstract][Full Text] [Related]  

  • 15. mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.
    Le Bacquer O; Queniat G; Gmyr V; Kerr-Conte J; Lefebvre B; Pattou F
    J Endocrinol; 2013 Jan; 216(1):21-9. PubMed ID: 23092880
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
    Guenther GG; Liu G; Ramirez MU; McMonigle RJ; Kim SM; McCracken AN; Joo Y; Ushach I; Nguyen NL; Edinger AL
    Oncogene; 2014 Apr; 33(14):1776-87. PubMed ID: 23604129
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
    Parkhitko AA; Priolo C; Coloff JL; Yun J; Wu JJ; Mizumura K; Xu W; Malinowska IA; Yu J; Kwiatkowski DJ; Locasale JW; Asara JM; Choi AM; Finkel T; Henske EP
    Mol Cancer Res; 2014 Jan; 12(1):48-57. PubMed ID: 24296756
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
    Tanwar PS; Kaneko-Tarui T; Zhang L; Tanaka Y; Crum CP; Teixeira JM
    PLoS Genet; 2012; 8(8):e1002906. PubMed ID: 22916036
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
    Ersoy BA; Tarun A; D'Aquino K; Hancer NJ; Ukomadu C; White MF; Michel T; Manning BD; Cohen DE
    Sci Signal; 2013 Jul; 6(286):ra64. PubMed ID: 23901139
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
    Bermudez-Silva FJ; Romero-Zerbo SY; Haissaguerre M; Ruz-Maldonado I; Lhamyani S; El Bekay R; Tabarin A; Marsicano G; Cota D
    Dis Model Mech; 2016 Jan; 9(1):51-61. PubMed ID: 26563389
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.