72 related articles for article (PubMed ID: 21887787)
1. Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro.
Jinno F; Yoneyama T; Morohashi A; Kondo T; Asahi S
Biopharm Drug Dispos; 2011 Oct; 32(7):408-25. PubMed ID: 21887787
[TBL] [Abstract][Full Text] [Related]
2. Investigation of the unique metabolic fate of ethyl (6R)-6- [N- (2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242) in rats and dogs using two types of 14C-labeled compounds having different labeled positions.
Jinno F; Kakehi M; Takeuchi T; Tagawa Y; Kondo T; Asahi S
Arzneimittelforschung; 2011; 61(8):458-71. PubMed ID: 21950150
[TBL] [Abstract][Full Text] [Related]
3. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Ii M; Matsunaga N; Hazeki K; Nakamura K; Takashima K; Seya T; Hazeki O; Kitazaki T; Iizawa Y
Mol Pharmacol; 2006 Apr; 69(4):1288-95. PubMed ID: 16373689
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate.
Yamada M; Ichikawa T; Ii M; Sunamoto M; Itoh K; Tamura N; Kitazaki T
J Med Chem; 2005 Nov; 48(23):7457-67. PubMed ID: 16279805
[TBL] [Abstract][Full Text] [Related]
5. Optically active cyclohexene derivative as a new antisepsis agent: an efficient synthesis of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242).
Yamada M; Ichikawa T; Yamano T; Kikumoto F; Nishikimi Y; Tamura N; Kitazaki T
Chem Pharm Bull (Tokyo); 2006 Jan; 54(1):58-62. PubMed ID: 16394550
[TBL] [Abstract][Full Text] [Related]
6. Toll-like receptor 4 antagonist attenuates intracerebral hemorrhage-induced brain injury.
Wang YC; Wang PF; Fang H; Chen J; Xiong XY; Yang QW
Stroke; 2013 Sep; 44(9):2545-52. PubMed ID: 23839500
[TBL] [Abstract][Full Text] [Related]
7. Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry.
Alvarez-Sánchez R; Divkovic M; Basketter D; Pease C; Panico M; Dell A; Morris H; Lepoittevin JP
Chem Res Toxicol; 2004 Sep; 17(9):1280-8. PubMed ID: 15377163
[TBL] [Abstract][Full Text] [Related]
8. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
Tang W; Borel AG; Abbott FS
Drug Metab Dispos; 1996 Apr; 24(4):436-46. PubMed ID: 8801059
[TBL] [Abstract][Full Text] [Related]
9. Reactivity of sulfenic acid in human serum albumin.
Turell L; Botti H; Carballal S; Ferrer-Sueta G; Souza JM; Durán R; Freeman BA; Radi R; Alvarez B
Biochemistry; 2008 Jan; 47(1):358-67. PubMed ID: 18078330
[TBL] [Abstract][Full Text] [Related]
10. Structure determination of a diuretic-glutathione conjugate by mass and n.m.r. spectrometry.
Higaki J; Kikuchi J; Ikenishi Y; Hirata M
Xenobiotica; 1991 Jan; 21(1):47-51. PubMed ID: 2003366
[TBL] [Abstract][Full Text] [Related]
11. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
Kassahun K; Farrell K; Abbott F
Drug Metab Dispos; 1991; 19(2):525-35. PubMed ID: 1676665
[TBL] [Abstract][Full Text] [Related]
12. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Matsunaga N; Tsuchimori N; Matsumoto T; Ii M
Mol Pharmacol; 2011 Jan; 79(1):34-41. PubMed ID: 20881006
[TBL] [Abstract][Full Text] [Related]
13. Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.
Carballal S; Radi R; Kirk MC; Barnes S; Freeman BA; Alvarez B
Biochemistry; 2003 Aug; 42(33):9906-14. PubMed ID: 12924939
[TBL] [Abstract][Full Text] [Related]
14. Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane.
Ross MK; Pegram RA
Chem Res Toxicol; 2003 Feb; 16(2):216-26. PubMed ID: 12588193
[TBL] [Abstract][Full Text] [Related]
15. Effect of its demethylated metabolite on the pharmacokinetics of unchanged TAK-603, a new antirheumatic agent, in rats.
Tagawa Y; Miwa K; Tsukuda R; Yoshimura Y; Tanayama S; Tanigawara Y
Drug Metab Dispos; 1999 Apr; 27(4):495-501. PubMed ID: 10101145
[TBL] [Abstract][Full Text] [Related]
16. Site-selective labeling of a lysine residue in human serum albumin.
Asano S; Patterson JT; Gaj T; Barbas CF
Angew Chem Int Ed Engl; 2014 Oct; 53(44):11783-6. PubMed ID: 25196737
[TBL] [Abstract][Full Text] [Related]
17. Characterization of HKI-272 covalent binding to human serum albumin.
Wang J; Li-Chan XX; Atherton J; Deng L; Espina R; Yu L; Horwatt P; Ross S; Lockhead S; Ahmad S; Chandrasekaran A; Oganesian A; Scatina J; Mutlib A; Talaat R
Drug Metab Dispos; 2010 Jul; 38(7):1083-93. PubMed ID: 20400660
[TBL] [Abstract][Full Text] [Related]
18. Bimolecular glutathione conjugation kinetics of ethacrynic acid in rat liver: in vitro and perfusion studies.
Tirona RG; Pang KS
J Pharmacol Exp Ther; 1999 Sep; 290(3):1230-41. PubMed ID: 10454499
[TBL] [Abstract][Full Text] [Related]
19. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
Grillo MP; Hua F; March KL; Benet LZ; Knutson CG; Ware JA
Chem Res Toxicol; 2008 Oct; 21(10):1933-8. PubMed ID: 18693772
[TBL] [Abstract][Full Text] [Related]
20. Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes.
Jansen RW; Kruijt JK; van Berkel TJ; Meijer DK
Hepatology; 1993 Jul; 18(1):146-52. PubMed ID: 7686877
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]