These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
7. Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Wun SJ; Johnson LA; You L; McGeary RP; Brueck T; Schenk G; Guddat LW Arch Biochem Biophys; 2020 Oct; 692():108516. PubMed ID: 32745463 [TBL] [Abstract][Full Text] [Related]
8. Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. Leung EW; Guddat LW J Mol Biol; 2009 May; 389(1):167-82. PubMed ID: 19362563 [TBL] [Abstract][Full Text] [Related]
9. Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery. Lv Y; Kandale A; Wun SJ; McGeary RP; Williams SJ; Kobe B; Sieber V; Schembri MA; Schenk G; Guddat LW FEBS J; 2016 Apr; 283(7):1184-96. PubMed ID: 26876563 [TBL] [Abstract][Full Text] [Related]
10. Stepwise building of a 115-kDa macromolecular edifice monitored by electrospray mass spectrometry. The case of acetohydroxy acid isomeroreductase. Laprévote O; Serani L; Das BC; Halgand F; Forest E; Dumas R Eur J Biochem; 1999 Jan; 259(1-2):356-9. PubMed ID: 9914514 [TBL] [Abstract][Full Text] [Related]
11. Metabolic effects of inhibitors of two enzymes of the branched-chain amino acid pathway in Salmonella typhimurium. Epelbaum S; Chipman DM; Barak Z J Bacteriol; 1996 Feb; 178(4):1187-96. PubMed ID: 8576056 [TBL] [Abstract][Full Text] [Related]
12. Purified recombinant Escherichia coli ketol-acid reductoisomerase is unsuitable for use in a coupled assay of acetohydroxyacid synthase activity due to an unexpected side reaction. Hill CM; Duggleby RG Protein Expr Purif; 1999 Feb; 15(1):57-61. PubMed ID: 10024470 [TBL] [Abstract][Full Text] [Related]
13. Kinetic and magnetic resonance studies of the role of metal ions in the mechanism of Escherichia coli GDP-mannose mannosyl hydrolase, an unusual nudix enzyme. Legler PM; Lee HC; Peisach J; Mildvan AS Biochemistry; 2002 Apr; 41(14):4655-68. PubMed ID: 11926828 [TBL] [Abstract][Full Text] [Related]
14. Reversal of the nucleotide specificity of ketol acid reductoisomerase by site-directed mutagenesis identifies the NADPH binding site. Rane MJ; Calvo KC Arch Biochem Biophys; 1997 Feb; 338(1):83-9. PubMed ID: 9015391 [TBL] [Abstract][Full Text] [Related]
15. Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Tyagi R; Lee YT; Guddat LW; Duggleby RG FEBS J; 2005 Jan; 272(2):593-602. PubMed ID: 15654896 [TBL] [Abstract][Full Text] [Related]
16. Structure of spinach acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxymethylvalerate, manganese and (phospho)-ADP-ribose. Thomazeau K; Dumas R; Halgand F; Forest E; Douce R; Biou V Acta Crystallogr D Biol Crystallogr; 2000 Apr; 56(Pt 4):389-97. PubMed ID: 10739911 [TBL] [Abstract][Full Text] [Related]
17. Metal Ions Play an Essential Catalytic Role in the Mechanism of Ketol-Acid Reductoisomerase. Tadrowski S; Pedroso MM; Sieber V; Larrabee JA; Guddat LW; Schenk G Chemistry; 2016 May; 22(22):7427-36. PubMed ID: 27136273 [TBL] [Abstract][Full Text] [Related]
18. The pH dependence of the kinetic parameters of ketol acid reductoisomerase indicates a proton shuttle mechanism for alkyl migration. Mrachko GT; Chunduru SK; Calvo KC Arch Biochem Biophys; 1992 May; 294(2):446-53. PubMed ID: 1567200 [TBL] [Abstract][Full Text] [Related]
19. High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Liu XH; Chen PQ; Wang BL; Dong WL; Li YH; Xie XQ; Li ZM Chem Biol Drug Des; 2010 Feb; 75(2):228-32. PubMed ID: 20028400 [TBL] [Abstract][Full Text] [Related]
20. Crystallization and preliminary crystallographic data for acetohydroxy acid isomeroreductase from Spinacia oleracea. Dumas R; Job D; Douce R; Pebay-Peyroula E; Cohen-Addad C J Mol Biol; 1994 Sep; 242(4):578-81. PubMed ID: 7932712 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]