BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 21908190)

  • 1. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.
    Dow RL; Andrews M; Aspnes GE; Balan G; Michael Gibbs E; Guzman-Perez A; Karki K; Laperle JL; Li JC; Litchfield J; Munchhof MJ; Perreault C; Patel L
    Bioorg Med Chem Lett; 2011 Oct; 21(20):6122-5. PubMed ID: 21908190
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
    Dow RL; Andrews MP; Li JC; Michael Gibbs E; Guzman-Perez A; Laperle JL; Li Q; Mather D; Munchhof MJ; Niosi M; Patel L; Perreault C; Tapley S; Zavadoski WJ
    Bioorg Med Chem; 2013 Sep; 21(17):5081-97. PubMed ID: 23871442
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors.
    Hong DJ; Jung SH; Kim J; Jung D; Ahn YG; Suh KH; Min KH
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):227-234. PubMed ID: 31752563
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability.
    Bali U; Barba O; Dawson G; Gattrell WT; Horswill JG; Pan DA; Procter MJ; Rasamison CM; Sambrook Smith CP; Taylor-Warne A; Wong-Kai-In P
    Bioorg Med Chem Lett; 2012 Jan; 22(2):824-8. PubMed ID: 22217874
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
    Kadam KS; Jadhav RD; Kandre S; Guha T; Reddy MM; Brahma MK; Deshmukh NJ; Dixit A; Doshi L; Srinivasan S; Devle J; Damre A; Nemmani KV; Gupte A; Sharma R
    Eur J Med Chem; 2013 Jul; 65():337-47. PubMed ID: 23735282
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.
    Lee K; Goo JI; Jung HY; Kim M; Boovanahalli SK; Park HR; Kim MO; Kim DH; Lee HS; Choi Y
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7456-60. PubMed ID: 23141914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.
    King AJ; Segreti JA; Larson KJ; Souers AJ; Kym PR; Reilly RM; Collins CA; Voorbach MJ; Zhao G; Mittelstadt SW; Cox BF
    Eur J Pharmacol; 2010 Jul; 637(1-3):155-61. PubMed ID: 20385122
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors.
    Lee K; Kim M; Lee B; Goo J; Kim J; Naik R; Seo JH; Kim MO; Byun Y; Song GY; Lee HS; Choi Y
    Org Biomol Chem; 2013 Feb; 11(5):849-58. PubMed ID: 23242135
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.
    Birch AM; Birtles S; Buckett LK; Kemmitt PD; Smith GJ; Smith TJ; Turnbull AV; Wang SJ
    J Med Chem; 2009 Mar; 52(6):1558-68. PubMed ID: 19256504
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
    McCoull W; Addie MS; Birch AM; Birtles S; Buckett LK; Butlin RJ; Bowker SS; Boyd S; Chapman S; Davies RD; Donald CS; Green CP; Jenner C; Kemmitt PD; Leach AG; Moody GC; Gutierrez PM; Newcombe NJ; Nowak T; Packer MJ; Plowright AT; Revill J; Schofield P; Sheldon C; Stokes S; Turnbull AV; Wang SJ; Whalley DP; Wood JM
    Bioorg Med Chem Lett; 2012 Jun; 22(12):3873-8. PubMed ID: 22608962
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors.
    Mougenot P; Namane C; Fett E; Goumy F; Dadji-Faïhun R; Langot G; Monseau C; Onofri B; Pacquet F; Pascal C; Crespin O; Ben-Hassine M; Ragot JL; Van-Pham T; Philippo C; Chatelain-Egger F; Péron P; Le Bail JC; Guillot E; Chamiot-Clerc P; Chabanaud MA; Pruniaux MP; Ménegotto J; Schmidt F; Venier O; Viviani F; Nicolai E
    Bioorg Med Chem Lett; 2016 Jan; 26(1):25-32. PubMed ID: 26627579
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster.
    King AJ; Segreti JA; Larson KJ; Souers AJ; Kym PR; Reilly RM; Zhao G; Mittelstadt SW; Cox BF
    J Pharmacol Exp Ther; 2009 Aug; 330(2):526-31. PubMed ID: 19478132
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
    Ting PC; Lee JF; Zorn N; Kim HM; Aslanian RG; Lin M; Smith M; Walker SS; Cook J; Van Heek M; Lachowicz J
    Bioorg Med Chem Lett; 2013 Feb; 23(4):985-8. PubMed ID: 23317570
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
    Qian Y; Wertheimer SJ; Ahmad M; Cheung AW; Firooznia F; Hamilton MM; Hayden S; Li S; Marcopulos N; McDermott L; Tan J; Yun W; Guo L; Pamidimukkala A; Chen Y; Huang KS; Ramsey GB; Whittard T; Conde-Knape K; Taub R; Rondinone CM; Tilley J; Bolin D
    J Med Chem; 2011 Apr; 54(7):2433-46. PubMed ID: 21413799
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.
    Naik R; Obiang-Obounou BW; Kim M; Choi Y; Lee HS; Lee K
    ChemMedChem; 2014 Nov; 9(11):2410-24. PubMed ID: 24954424
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
    Yeh VS; Beno DW; Brodjian S; Brune ME; Cullen SC; Dayton BD; Dhaon MK; Falls HD; Gao J; Grihalde N; Hajduk P; Hansen TM; Judd AS; King AJ; Klix RC; Larson KJ; Lau YY; Marsh KC; Mittelstadt SW; Plata D; Rozema MJ; Segreti JA; Stoner EJ; Voorbach MJ; Wang X; Xin X; Zhao G; Collins CA; Cox BF; Reilly RM; Kym PR; Souers AJ
    J Med Chem; 2012 Feb; 55(4):1751-7. PubMed ID: 22263872
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.
    Kandre S; Bhagat PR; Reddy MM; Dalal R; Dixit A; Deshmukh NJ; Anthony J; Bose J; Anupindi R; Sharma R; Gupte A
    Eur J Med Chem; 2014 May; 79():203-15. PubMed ID: 24735646
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.
    Motiwala H; Kandre S; Birar V; Kadam KS; Rodge A; Jadhav RD; Mahesh Kumar Reddy M; Brahma MK; Deshmukh NJ; Dixit A; Doshi L; Gupte A; Gangopadhyay AK; Vishwakarma RA; Srinivasan S; Sharma M; Nemmani KV; Sharma R
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5812-7. PubMed ID: 21868220
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents.
    King AJ; Judd AS; Souers AJ
    Expert Opin Ther Pat; 2010 Jan; 20(1):19-29. PubMed ID: 20021283
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
    Zhou G; Ting PC; Wishart G; Zorn N; Aslanian RG; Lin M; Smith M; Walker SS; Cook J; Van Heek M; Lachowicz J
    Bioorg Med Chem Lett; 2014 Apr; 24(7):1790-4. PubMed ID: 24618302
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.