313 related articles for article (PubMed ID: 21908616)
1. IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Guo JP; Coppola D; Cheng JQ
J Biol Chem; 2011 Oct; 286(43):37389-98. PubMed ID: 21908616
[TBL] [Abstract][Full Text] [Related]
2. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Xie X; Zhang D; Zhao B; Lu MK; You M; Condorelli G; Wang CY; Guan KL
Proc Natl Acad Sci U S A; 2011 Apr; 108(16):6474-9. PubMed ID: 21464307
[TBL] [Abstract][Full Text] [Related]
3. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
Tsuchiya A; Kanno T; Nishizaki T
J Endocrinol; 2014 Jan; 220(1):49-59. PubMed ID: 24169049
[TBL] [Abstract][Full Text] [Related]
4. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Maurer M; Su T; Saal LH; Koujak S; Hopkins BD; Barkley CR; Wu J; Nandula S; Dutta B; Xie Y; Chin YR; Kim DI; Ferris JS; Gruvberger-Saal SK; Laakso M; Wang X; Memeo L; Rojtman A; Matos T; Yu JS; Cordon-Cardo C; Isola J; Terry MB; Toker A; Mills GB; Zhao JJ; Murty VV; Hibshoosh H; Parsons R
Cancer Res; 2009 Aug; 69(15):6299-306. PubMed ID: 19602588
[TBL] [Abstract][Full Text] [Related]
5. 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
Gagliardi PA; di Blasio L; Orso F; Seano G; Sessa R; Taverna D; Bussolino F; Primo L
Neoplasia; 2012 Aug; 14(8):719-31. PubMed ID: 22952425
[TBL] [Abstract][Full Text] [Related]
6. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.
Kondapaka SB; Singh SS; Dasmahapatra GP; Sausville EA; Roy KK
Mol Cancer Ther; 2003 Nov; 2(11):1093-103. PubMed ID: 14617782
[TBL] [Abstract][Full Text] [Related]
7. Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition.
Samartzis EP; Gutsche K; Dedes KJ; Fink D; Stucki M; Imesch P
Oncotarget; 2014 Jul; 5(14):5295-303. PubMed ID: 24979463
[TBL] [Abstract][Full Text] [Related]
8. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Sundaresan NR; Pillai VB; Wolfgeher D; Samant S; Vasudevan P; Parekh V; Raghuraman H; Cunningham JM; Gupta M; Gupta MP
Sci Signal; 2011 Jul; 4(182):ra46. PubMed ID: 21775285
[TBL] [Abstract][Full Text] [Related]
9. Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
Liao XH; Buggey J; Kimmel AR
J Cell Sci; 2010 Mar; 123(Pt 6):983-92. PubMed ID: 20200230
[TBL] [Abstract][Full Text] [Related]
10. Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.
Baxi SM; Tan W; Murphy ST; Smeal T; Yin MJ
PLoS One; 2012; 7(10):e48402. PubMed ID: 23119004
[TBL] [Abstract][Full Text] [Related]
11. Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate.
Gan X; Wang J; Su B; Wu D
J Biol Chem; 2011 Apr; 286(13):10998-1002. PubMed ID: 21310961
[TBL] [Abstract][Full Text] [Related]
12. RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.
Kim DW; Hwang JH; Suh JM; Kim H; Song JH; Hwang ES; Hwang IY; Park KC; Chung HK; Kim JM; Park J; Hemmings BA; Shong M
Mol Endocrinol; 2003 Jul; 17(7):1382-94. PubMed ID: 12738763
[TBL] [Abstract][Full Text] [Related]
13. Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.
Kikani CK; Verona EV; Ryu J; Shen Y; Ye Q; Zheng L; Qian Z; Sakaue H; Nakamura K; Du J; Ji Q; Ogawa W; Sun LZ; Dong LQ; Liu F
Sci Signal; 2012 Nov; 5(249):ra80. PubMed ID: 23131847
[TBL] [Abstract][Full Text] [Related]
14. PI3K/Akt promotes feedforward mTORC2 activation through IKKα.
Dan HC; Antonia RJ; Baldwin AS
Oncotarget; 2016 Apr; 7(16):21064-75. PubMed ID: 27027448
[TBL] [Abstract][Full Text] [Related]
15. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.
Warfel NA; Niederst M; Newton AC
J Biol Chem; 2011 Nov; 286(45):39122-9. PubMed ID: 21908613
[TBL] [Abstract][Full Text] [Related]
16. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.
Rodríguez-Escudero I; Roelants FM; Thorner J; Nombela C; Molina M; Cid VJ
Biochem J; 2005 Sep; 390(Pt 2):613-23. PubMed ID: 15913452
[TBL] [Abstract][Full Text] [Related]
17. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
Kim D; Sun M; He L; Zhou QH; Chen J; Sun XM; Bepler G; Sebti SM; Cheng JQ
J Biol Chem; 2010 Mar; 285(11):8383-94. PubMed ID: 20068047
[TBL] [Abstract][Full Text] [Related]
18. Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia.
Cani A; Simioni C; Martelli AM; Zauli G; Tabellini G; Ultimo S; McCubrey JA; Capitani S; Neri LM
Oncotarget; 2015 Mar; 6(9):6597-610. PubMed ID: 25788264
[TBL] [Abstract][Full Text] [Related]
19. PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model.
Du J; Yang M; Chen S; Li D; Chang Z; Dong Z
Oncogene; 2016 Jun; 35(25):3314-23. PubMed ID: 26455327
[TBL] [Abstract][Full Text] [Related]
20. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
Kim S; Jee K; Kim D; Koh H; Chung J
J Biol Chem; 2001 Apr; 276(16):12864-70. PubMed ID: 11278269
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]