108 related articles for article (PubMed ID: 21920744)
1. Tricyclic aminopyrimidine histamine H4 receptor antagonists.
Savall BM; Gomez L; Chavez F; Curtis M; Meduna SP; Kearney A; Dunford P; Cowden J; Thurmond RL; Grice C; Edwards JP
Bioorg Med Chem Lett; 2011 Nov; 21(21):6577-81. PubMed ID: 21920744
[TBL] [Abstract][Full Text] [Related]
2. Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring.
Koenig JR; Liu H; Drizin I; Witte DG; Carr TL; Manelli AM; Milicic I; Strakhova MI; Miller TR; Esbenshade TA; Brioni JD; Cowart M
Bioorg Med Chem Lett; 2010 Mar; 20(6):1900-4. PubMed ID: 20171098
[TBL] [Abstract][Full Text] [Related]
3. Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Masood MA; Selby MD; Bell AS; Mansfield AC; Gardner M; Smith GF; Lane C; Kenyon-Edwards H; Osborne R; Jones RM; Liu WL; Brown CD; Clarke N; Perrucio F; Mowbray CE
Bioorg Med Chem Lett; 2011 Nov; 21(21):6591-5. PubMed ID: 21955944
[TBL] [Abstract][Full Text] [Related]
4. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Cramp S; Dyke HJ; Higgs C; Clark DE; Gill M; Savy P; Jennings N; Price S; Lockey PM; Norman D; Porres S; Wilson F; Jones A; Ramsden N; Mangano R; Leggate D; Andersson M; Hale R
Bioorg Med Chem Lett; 2010 Apr; 20(8):2516-9. PubMed ID: 20299215
[TBL] [Abstract][Full Text] [Related]
5. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Savall BM; Chavez F; Tays K; Dunford PJ; Cowden JM; Hack MD; Wolin RL; Thurmond RL; Edwards JP
J Med Chem; 2014 Mar; 57(6):2429-39. PubMed ID: 24495018
[TBL] [Abstract][Full Text] [Related]
6. Histamine H4 receptor antagonists: the new antihistamines?
Fung-Leung WP; Thurmond RL; Ling P; Karlsson L
Curr Opin Investig Drugs; 2004 Nov; 5(11):1174-83. PubMed ID: 15573868
[TBL] [Abstract][Full Text] [Related]
7. Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
Savall BM; Edwards JP; Venable JD; Buzard DJ; Thurmond R; Hack M; McGovern P
Bioorg Med Chem Lett; 2010 Jun; 20(11):3367-71. PubMed ID: 20452213
[TBL] [Abstract][Full Text] [Related]
8. Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Altenbach RJ; Adair RM; Bettencourt BM; Black LA; Fix-Stenzel SR; Gopalakrishnan SM; Hsieh GC; Liu H; Marsh KC; McPherson MJ; Milicic I; Miller TR; Vortherms TA; Warrior U; Wetter JM; Wishart N; Witte DG; Honore P; Esbenshade TA; Hancock AA; Brioni JD; Cowart MD
J Med Chem; 2008 Oct; 51(20):6571-80. PubMed ID: 18811133
[TBL] [Abstract][Full Text] [Related]
9. The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Jablonowski JA; Grice CA; Chai W; Dvorak CA; Venable JD; Kwok AK; Ly KS; Wei J; Baker SM; Desai PJ; Jiang W; Wilson SJ; Thurmond RL; Karlsson L; Edwards JP; Lovenberg TW; Carruthers NI
J Med Chem; 2003 Sep; 46(19):3957-60. PubMed ID: 12954048
[TBL] [Abstract][Full Text] [Related]
10. Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.
Watanabe M; Kazuta Y; Hayashi H; Yamada S; Matsuda A; Shuto S
J Med Chem; 2006 Sep; 49(18):5587-96. PubMed ID: 16942032
[TBL] [Abstract][Full Text] [Related]
11. Major advances in the development of histamine H4 receptor ligands.
Smits RA; Leurs R; de Esch IJ
Drug Discov Today; 2009 Aug; 14(15-16):745-53. PubMed ID: 19477292
[TBL] [Abstract][Full Text] [Related]
12. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Venable JD; Cai H; Chai W; Dvorak CA; Grice CA; Jablonowski JA; Shah CR; Kwok AK; Ly KS; Pio B; Wei J; Desai PJ; Jiang W; Nguyen S; Ling P; Wilson SJ; Dunford PJ; Thurmond RL; Lovenberg TW; Karlsson L; Carruthers NI; Edwards JP
J Med Chem; 2005 Dec; 48(26):8289-98. PubMed ID: 16366610
[TBL] [Abstract][Full Text] [Related]
13. Histamine H4 receptor ligands and their potential therapeutic applications.
Kiss R; Keseru GM
Expert Opin Ther Pat; 2009 Feb; 19(2):119-35. PubMed ID: 19441913
[TBL] [Abstract][Full Text] [Related]
14. Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
Tichenor MS; Thurmond RL; Venable JD; Savall BM
J Med Chem; 2015 Sep; 58(18):7119-27. PubMed ID: 25993395
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists.
Labeeuw O; Levoin N; Billot X; Danvy D; Calmels T; Krief S; Ligneau X; Berrebi-Bertrand I; Robert P; Lecomte JM; Schwartz JC; Capet M
Bioorg Med Chem Lett; 2016 Nov; 26(21):5263-5266. PubMed ID: 27692832
[TBL] [Abstract][Full Text] [Related]
16. Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands.
Schreeb A; Walter M; Odadzic D; Schwed JS; Weizel L; Stark H
Pharmazie; 2013 Jul; 68(7):521-5. PubMed ID: 23923631
[TBL] [Abstract][Full Text] [Related]
17. Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Smits RA; Lim HD; van der Meer T; Kuhne S; Bessembinder K; Zuiderveld OP; Wijtmans M; de Esch IJ; Leurs R
Bioorg Med Chem Lett; 2012 Jan; 22(1):461-7. PubMed ID: 22153663
[TBL] [Abstract][Full Text] [Related]
18. Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Kiss R; Kiss B; Könczöl A; Szalai F; Jelinek I; László V; Noszál B; Falus A; Keseru GM
J Med Chem; 2008 Jun; 51(11):3145-53. PubMed ID: 18459760
[TBL] [Abstract][Full Text] [Related]
19. A bioinformatics search for selective histamine h4 receptor antagonists through structure-based virtual screening strategies.
Christopher F; Thangam EB; Suresh MX
Chem Biol Drug Des; 2012 May; 79(5):749-59. PubMed ID: 22260722
[TBL] [Abstract][Full Text] [Related]
20. Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands.
Schneider EH; Strasser A; Thurmond RL; Seifert R
J Pharmacol Exp Ther; 2010 Aug; 334(2):513-21. PubMed ID: 20484153
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]