BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

223 related articles for article (PubMed ID: 21924775)

  • 1. From agonist to antagonist: structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins.
    DeMarco ML; Woods RJ
    Mol Immunol; 2011 Oct; 49(1-2):124-33. PubMed ID: 21924775
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bordetella pertussis Lipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces.
    Maeshima N; Evans-Atkinson T; Hajjar AM; Fernandez RC
    J Biol Chem; 2015 May; 290(21):13440-53. PubMed ID: 25837248
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
    Ohto U; Fukase K; Miyake K; Shimizu T
    Proc Natl Acad Sci U S A; 2012 May; 109(19):7421-6. PubMed ID: 22532668
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics.
    Heine H; Adanitsch F; Peternelj TT; Haegman M; Kasper C; Ittig S; Beyaert R; Jerala R; Zamyatina A
    Front Immunol; 2021; 12():631797. PubMed ID: 33815382
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia.
    Di Lorenzo F; Kubik Ł; Oblak A; Lorè NI; Cigana C; Lanzetta R; Parrilli M; Hamad MA; De Soyza A; Silipo A; Jerala R; Bragonzi A; Valvano MA; Martín-Santamaría S; Molinaro A
    J Biol Chem; 2015 Aug; 290(35):21305-19. PubMed ID: 26160169
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Recognition of lipid A variants by the TLR4-MD-2 receptor complex.
    Maeshima N; Fernandez RC
    Front Cell Infect Microbiol; 2013; 3():3. PubMed ID: 23408095
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway.
    Huber RG; Berglund NA; Kargas V; Marzinek JK; Holdbrook DA; Khalid S; Piggot TJ; Schmidtchen A; Bond PJ
    Structure; 2018 Aug; 26(8):1151-1161.e4. PubMed ID: 29779787
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.
    Yu L; Phillips RL; Zhang D; Teghanemt A; Weiss JP; Gioannini TL
    J Biol Chem; 2012 May; 287(20):16346-55. PubMed ID: 22433852
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.
    Park BS; Song DH; Kim HM; Choi BS; Lee H; Lee JO
    Nature; 2009 Apr; 458(7242):1191-5. PubMed ID: 19252480
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.
    Resman N; Vasl J; Oblak A; Pristovsek P; Gioannini TL; Weiss JP; Jerala R
    J Biol Chem; 2009 May; 284(22):15052-60. PubMed ID: 19321453
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.
    Hajjar AM; Ernst RK; Fortuno ES; Brasfield AS; Yam CS; Newlon LA; Kollmann TR; Miller SI; Wilson CB
    PLoS Pathog; 2012; 8(10):e1002963. PubMed ID: 23071439
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4.
    Zimmer SM; Zughaier SM; Tzeng YL; Stephens DS
    Glycobiology; 2007 Aug; 17(8):847-56. PubMed ID: 17545685
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.
    Oblak A; Jerala R
    PLoS One; 2014; 9(9):e107520. PubMed ID: 25203747
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.
    Garate JA; Stöckl J; Fernández-Alonso Mdel C; Artner D; Haegman M; Oostenbrink C; Jiménez-Barbero J; Beyaert R; Heine H; Kosma P; Zamyatina A
    Innate Immun; 2015 Jul; 21(5):490-503. PubMed ID: 25394365
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.
    Gioannini TL; Teghanemt A; Zhang D; Esparza G; Yu L; Weiss J
    Immunol Res; 2014 Aug; 59(1-3):3-11. PubMed ID: 24895101
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
    Meng J; Lien E; Golenbock DT
    J Biol Chem; 2010 Mar; 285(12):8695-702. PubMed ID: 20018893
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.
    Teghanemt A; Re F; Prohinar P; Widstrom R; Gioannini TL; Weiss JP
    J Biol Chem; 2008 Jan; 283(3):1257-1266. PubMed ID: 17977838
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions.
    Resman N; Oblak A; Gioannini TL; Weiss JP; Jerala R
    J Immunol; 2014 Feb; 192(4):1887-95. PubMed ID: 24420921
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
    Okamoto N; Mizote K; Honda H; Saeki A; Watanabe Y; Yamaguchi-Miyamoto T; Fukui R; Tanimura N; Motoi Y; Akashi-Takamura S; Kato T; Fujishita S; Kimura T; Ohto U; Shimizu T; Hirokawa T; Miyake K; Fukase K; Fujimoto Y; Nagai Y; Takatsu K
    J Biol Chem; 2017 Sep; 292(37):15378-15394. PubMed ID: 28754693
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The molecular basis of the host response to lipopolysaccharide.
    Bryant CE; Spring DR; Gangloff M; Gay NJ
    Nat Rev Microbiol; 2010 Jan; 8(1):8-14. PubMed ID: 19946286
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.