BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 21925887)

  • 1. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
    Vardanyan R; Kumirov VK; Nichol GS; Davis P; Liktor-Busa E; Rankin D; Varga E; Vanderah T; Porreca F; Lai J; Hruby VJ
    Bioorg Med Chem; 2011 Oct; 19(20):6135-42. PubMed ID: 21925887
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist-Neurokinin Antagonist Peptidomimetics.
    Gadais C; Piekielna-Ciesielska J; De Neve J; Martin C; Janecka A; Ballet S
    Molecules; 2021 Sep; 26(17):. PubMed ID: 34500841
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse.
    Neumeyer JL; Mello NK; Negus SS; Bidlack JM
    Pharm Acta Helv; 2000 Mar; 74(2-3):337-44. PubMed ID: 10812979
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
    Yamamoto T; Nair P; Jacobsen NE; Kulkarni V; Davis P; Ma SW; Navratilova E; Yamamura HI; Vanderah TW; Porreca F; Lai J; Hruby VJ
    J Med Chem; 2010 Aug; 53(15):5491-501. PubMed ID: 20617791
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.
    Starnowska J; Costante R; Guillemyn K; Popiolek-Barczyk K; Chung NN; Lemieux C; Keresztes A; Van Duppen J; Mollica A; Streicher J; Vanden Broeck J; Schiller PW; Tourwé D; Mika J; Ballet S; Przewlocka B
    ACS Chem Neurosci; 2017 Oct; 8(10):2315-2324. PubMed ID: 28699350
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors.
    Wtorek K; Adamska-Bartłomiejczyk A; Piekielna-Ciesielska J; Ferrari F; Ruzza C; Kluczyk A; Piasecka-Zelga J; Calo' G; Janecka A
    Molecules; 2019 Dec; 24(24):. PubMed ID: 31817441
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
    Ballet S; Feytens D; Buysse K; Chung NN; Lemieux C; Tumati S; Keresztes A; Van Duppen J; Lai J; Varga E; Porreca F; Schiller PW; Vanden Broeck J; Tourwé D
    J Med Chem; 2011 Apr; 54(7):2467-76. PubMed ID: 21413804
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
    Yamamoto T; Nair P; Largent-Milnes TM; Jacobsen NE; Davis P; Ma SW; Yamamura HI; Vanderah TW; Porreca F; Lai J; Hruby VJ
    J Med Chem; 2011 Apr; 54(7):2029-38. PubMed ID: 21366266
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.
    Schiller PW; Berezowska I; Nguyen TM; Schmidt R; Lemieux C; Chung NN; Falcone-Hindley ML; Yao W; Liu J; Iwama S; Smith AB; Hirschmann R
    J Med Chem; 2000 Feb; 43(4):551-9. PubMed ID: 10691681
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.
    Giri AK; Apostol CR; Wang Y; Forte BL; Largent-Milnes TM; Davis P; Rankin D; Molnar G; Olson KM; Porreca F; Vanderah TW; Hruby VJ
    J Med Chem; 2015 Nov; 58(21):8573-83. PubMed ID: 26465170
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
    MacLeod AM; Cascieri MA; Merchant KJ; Sadowski S; Hardwicke S; Lewis RT; MacIntyre DE; Metzger JM; Fong TM; Shepheard S
    J Med Chem; 1995 Mar; 38(6):934-41. PubMed ID: 7535362
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
    MacLeod AM; Merchant KJ; Brookfield F; Kelleher F; Stevenson G; Owens AP; Swain CJ; Casiceri MA; Sadowski S; Ber E
    J Med Chem; 1994 Apr; 37(9):1269-74. PubMed ID: 7513763
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification.
    Recio R; Vengut-Climent E; Mouillac B; Orcel H; López-Lázaro M; Calderón-Montaño JM; Álvarez E; Khiar N; Fernández I
    Eur J Med Chem; 2017 Sep; 138():644-660. PubMed ID: 28710964
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera.
    Guillemyn K; Kleczkowska P; Novoa A; Vandormael B; Van den Eynde I; Kosson P; Asim MF; Schiller PW; Spetea M; Lipkowski AW; Tourwé D; Ballet S
    Mol Brain; 2012 Jan; 5():4. PubMed ID: 22289619
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
    Lenard NR; Daniels DJ; Portoghese PS; Roerig SC
    Eur J Pharmacol; 2007 Jul; 566(1-3):75-82. PubMed ID: 17383633
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.
    Le Naour M; Akgün E; Yekkirala A; Lunzer MM; Powers MD; Kalyuzhny AE; Portoghese PS
    J Med Chem; 2013 Jul; 56(13):5505-13. PubMed ID: 23734559
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
    Vardanyan R; Vijay G; Nichol GS; Liu L; Kumarasinghe I; Davis P; Vanderah T; Porreca F; Lai J; Hruby VJ
    Bioorg Med Chem; 2009 Jul; 17(14):5044-53. PubMed ID: 19540763
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites.
    Dardonville C; Fernandez-Fernandez C; Gibbons SL; Ryan GJ; Jagerovic N; Gabilondo AM; Meana JJ; Callado LF
    Bioorg Med Chem; 2006 Oct; 14(19):6570-80. PubMed ID: 16797997
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist.
    Cascieri MA; Ber E; Fong TM; Hale JJ; Tang F; Shiao LL; Mills SG; MacCoss M; Sadowski S; Tota MR; Strader CD
    Eur J Pharmacol; 1997 May; 325(2-3):253-61. PubMed ID: 9163573
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
    Nair P; Yamamoto T; Largent-Milnes TM; Cowell S; Kulkarni V; Moye S; Navratilova E; Davis P; Ma SW; Vanderah TW; Lai J; Porreca F; Hruby VJ
    Bioorg Med Chem Lett; 2013 Sep; 23(17):4975-8. PubMed ID: 23899615
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.