BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 21935950)

  • 1. Developability index: a rapid in silico tool for the screening of antibody aggregation propensity.
    Lauer TM; Agrawal NJ; Chennamsetty N; Egodage K; Helk B; Trout BL
    J Pharm Sci; 2012 Jan; 101(1):102-15. PubMed ID: 21935950
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Prediction of aggregation prone regions of therapeutic proteins.
    Chennamsetty N; Voynov V; Kayser V; Helk B; Trout BL
    J Phys Chem B; 2010 May; 114(19):6614-24. PubMed ID: 20411962
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aggregation risk prediction for antibodies and its application to biotherapeutic development.
    Obrezanova O; Arnell A; de la Cuesta RG; Berthelot ME; Gallagher TR; Zurdo J; Stallwood Y
    MAbs; 2015; 7(2):352-63. PubMed ID: 25760769
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intrinsic physicochemical profile of marketed antibody-based biotherapeutics.
    Ahmed L; Gupta P; Martin KP; Scheer JM; Nixon AE; Kumar S
    Proc Natl Acad Sci U S A; 2021 Sep; 118(37):. PubMed ID: 34504010
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Five computational developability guidelines for therapeutic antibody profiling.
    Raybould MIJ; Marks C; Krawczyk K; Taddese B; Nowak J; Lewis AP; Bujotzek A; Shi J; Deane CM
    Proc Natl Acad Sci U S A; 2019 Mar; 116(10):4025-4030. PubMed ID: 30765520
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations.
    Wang X; Kumar S; Buck PM; Singh SK
    Proteins; 2013 Mar; 81(3):443-60. PubMed ID: 23065923
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs.
    Clark RH; Latypov RF; De Imus C; Carter J; Wilson Z; Manchulenko K; Brown ME; Ketchem RR
    MAbs; 2014; 6(6):1540-50. PubMed ID: 25484048
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers.
    Heads JT; Kelm S; Tyson K; Lawson ADG
    MAbs; 2022; 14(1):2138092. PubMed ID: 36418193
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies.
    Jetha A; Thorsteinson N; Jmeian Y; Jeganathan A; Giblin P; Fransson J
    MAbs; 2018; 10(6):890-900. PubMed ID: 30110240
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
    Perchiacca JM; Lee CC; Tessier PM
    Protein Eng Des Sel; 2014 Feb; 27(2):29-39. PubMed ID: 24398633
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions.
    Nichols P; Li L; Kumar S; Buck PM; Singh SK; Goswami S; Balthazor B; Conley TR; Sek D; Allen MJ
    MAbs; 2015; 7(1):212-30. PubMed ID: 25559441
    [TBL] [Abstract][Full Text] [Related]  

  • 12. AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches.
    Sankar K; Krystek SR; Carl SM; Day T; Maier JKX
    Proteins; 2018 Nov; 86(11):1147-1156. PubMed ID: 30168197
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry.
    Shieh IC; Patel AR
    Mol Pharm; 2015 Sep; 12(9):3184-93. PubMed ID: 26198590
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
    Shan L; Mody N; Sormani P; Rosenthal KL; Damschroder MM; Esfandiary R
    Mol Pharm; 2018 Dec; 15(12):5697-5710. PubMed ID: 30395473
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations.
    Kumar V; Dixit N; Zhou LL; Fraunhofer W
    Int J Pharm; 2011 Dec; 421(1):82-93. PubMed ID: 21959107
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.
    Yamniuk AP; Ditto N; Patel M; Dai J; Sejwal P; Stetsko P; Doyle ML
    J Pharm Sci; 2013 Aug; 102(8):2424-39. PubMed ID: 23712759
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability.
    Heads JT; Lamb R; Kelm S; Adams R; Elliott P; Tyson K; Topia S; West S; Nan R; Turner A; Lawson ADG
    Protein Eng Des Sel; 2019 Dec; 32(6):277-288. PubMed ID: 31868219
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics.
    Buck PM; Kumar S; Singh SK
    Protein Eng Des Sel; 2013 Mar; 26(3):195-205. PubMed ID: 23188804
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions.
    Agrawal NJ; Kumar S; Wang X; Helk B; Singh SK; Trout BL
    J Pharm Sci; 2011 Dec; 100(12):5081-95. PubMed ID: 21789769
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions.
    Perchiacca JM; Ladiwala AR; Bhattacharya M; Tessier PM
    Protein Eng Des Sel; 2012 Oct; 25(10):591-601. PubMed ID: 22843678
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.