84 related articles for article (PubMed ID: 21939274)
1. Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Sharma R; Eng H; Walker GS; Barreiro G; Stepan AF; McClure KF; Wolford A; Bonin PD; Cornelius P; Kalgutkar AS
Chem Res Toxicol; 2011 Dec; 24(12):2207-16. PubMed ID: 21939274
[TBL] [Abstract][Full Text] [Related]
2. Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
Eng H; Niosi M; McDonald TS; Wolford A; Chen Y; Simila ST; Bauman JN; Warmus J; Kalgutkar AS
Xenobiotica; 2010 Jun; 40(6):369-80. PubMed ID: 20297923
[TBL] [Abstract][Full Text] [Related]
3. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu
Crouch RD; Blobaum AL; Felts AS; Conn PJ; Lindsley CW
Drug Metab Dispos; 2017 Dec; 45(12):1245-1259. PubMed ID: 28939686
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Gao J; Liu X; Zhang B; Mao Q; Zhang Z; Zou Q; Dai X; Wang S
Eur J Med Chem; 2020 Mar; 190():112077. PubMed ID: 32014678
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.
Song JU; Choi SP; Kim TH; Jung CK; Lee JY; Jung SH; Kim GT
Bioorg Med Chem Lett; 2015 Mar; 25(6):1254-8. PubMed ID: 25704891
[TBL] [Abstract][Full Text] [Related]
6. Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes.
Radi R; Rubbo H; Bush K; Freeman BA
Arch Biochem Biophys; 1997 Mar; 339(1):125-35. PubMed ID: 9056242
[TBL] [Abstract][Full Text] [Related]
7. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
[TBL] [Abstract][Full Text] [Related]
8. Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct.
Gu C; Elmore CS; Lin J; Zhou D; Luzietti R; Dorff P; Grimm SW
Drug Metab Dispos; 2012 Jun; 40(6):1151-63. PubMed ID: 22397852
[TBL] [Abstract][Full Text] [Related]
9. Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
Scott JS; Birch AM; Brocklehurst KJ; Broo A; Brown HS; Butlin RJ; Clarke DS; Davidsson O; Ertan A; Goldberg K; Groombridge SD; Hudson JA; Laber D; Leach AG; Macfaul PA; McKerrecher D; Pickup A; Schofield P; Svensson PH; Sörme P; Teague J
J Med Chem; 2012 Jun; 55(11):5361-79. PubMed ID: 22545772
[TBL] [Abstract][Full Text] [Related]
10. Involvement of xanthine oxidase in oxidative stress and iron release during hyperthermic rat liver perfusion.
Powers RH; Stadnicka A; Kalbfleish JH; Skibba JL
Cancer Res; 1992 Apr; 52(7):1699-703. PubMed ID: 1551099
[TBL] [Abstract][Full Text] [Related]
11. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
Morrison RD; Blobaum AL; Byers FW; Santomango TS; Bridges TM; Stec D; Brewer KA; Sanchez-Ponce R; Corlew MM; Rush R; Felts AS; Manka J; Bates BS; Venable DF; Rodriguez AL; Jones CK; Niswender CM; Conn PJ; Lindsley CW; Emmitte KA; Daniels JS
Drug Metab Dispos; 2012 Sep; 40(9):1834-45. PubMed ID: 22711749
[TBL] [Abstract][Full Text] [Related]
12. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Evenäs J; Edfeldt F; Lepistö M; Svitacheva N; Synnergren A; Lundquist B; Gränse M; Rönnholm A; Varga M; Wright J; Wei M; Yue S; Wang J; Li C; Li X; Chen G; Liao Y; Lv G; Tjörnebo A; Narjes F
Bioorg Med Chem Lett; 2014 Mar; 24(5):1315-21. PubMed ID: 24508129
[TBL] [Abstract][Full Text] [Related]
13. Metabolism of [(14)C]GSK977779 in rats and its implication with the observed covalent binding.
Tsalta CD; Madatian A; Schubert EM; Xia F; Hardesty WM; Deng Y; Seymour JL; Gorycki PD
Drug Metab Dispos; 2011 Sep; 39(9):1620-32. PubMed ID: 21628498
[TBL] [Abstract][Full Text] [Related]
14. Endotoxin challenge increases xanthine oxidase activity in cattle: effect of growth hormone and vitamin E treatment.
Kahl S; Elsasser TH
Domest Anim Endocrinol; 2004 May; 26(4):315-28. PubMed ID: 15063924
[TBL] [Abstract][Full Text] [Related]
15. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
[TBL] [Abstract][Full Text] [Related]
16. Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.
Kalgutkar AS; Mascitti V; Sharma R; Walker GW; Ryder T; McDonald TS; Chen Y; Preville C; Basak A; McClure KF; Kohrt JT; Robinson RP; Munchhof MJ; Cornelius P
Chem Res Toxicol; 2011 Feb; 24(2):269-78. PubMed ID: 21288051
[TBL] [Abstract][Full Text] [Related]
17. Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.
Hong H; Caceres-Cortes J; Su H; Huang X; Roongta V; Bonacorsi S; Hong Y; Tian Y; Iyer RA; Humphreys WG; Christopher LJ
Chem Res Toxicol; 2011 Jan; 24(1):125-34. PubMed ID: 21080678
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one.
Sakairi M; Kogami M; Torii M; Makino M; Kataoka D; Okamoto R; Miyazawa T; Inoue M; Takahashi N; Harada S; Watanabe N
Chem Pharm Bull (Tokyo); 2012; 60(9):1093-5. PubMed ID: 22976315
[TBL] [Abstract][Full Text] [Related]
19. Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists.
Wang Y; Yu M; Zhu J; Zhang JK; Kayser F; Medina JC; Siegler K; Conn M; Shan B; Grillo MP; Liu JJ; Coward P
Bioorg Med Chem Lett; 2014 Feb; 24(4):1133-7. PubMed ID: 24440299
[TBL] [Abstract][Full Text] [Related]
20. Presence of epidermal allantoin further supports oxidative stress in vitiligo.
Shalbaf M; Gibbons NC; Wood JM; Maitland DJ; Rokos H; Elwary SM; Marles LK; Schallreuter KU
Exp Dermatol; 2008 Sep; 17(9):761-70. PubMed ID: 18328088
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
