BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

243 related articles for article (PubMed ID: 21944546)

  • 1. Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands.
    Peduto A; Pagano B; Petronzi C; Massa A; Esposito V; Virgilio A; Paduano F; Trapasso F; Fiorito F; Florio S; Giancola C; Galeone A; Filosa R
    Bioorg Med Chem; 2011 Nov; 19(21):6419-29. PubMed ID: 21944546
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
    Lu YJ; Ou TM; Tan JH; Hou JQ; Shao WY; Peng D; Sun N; Wang XD; Wu WB; Bu XZ; Huang ZS; Ma DL; Wong KY; Gu LQ
    J Med Chem; 2008 Oct; 51(20):6381-92. PubMed ID: 18821749
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.
    Tan JH; Ou TM; Hou JQ; Lu YJ; Huang SL; Luo HB; Wu JY; Huang ZS; Wong KY; Gu LQ
    J Med Chem; 2009 May; 52(9):2825-35. PubMed ID: 19354252
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Tröger's base based novel benzimidazole derivatives.
    Paul A; Maji B; Misra SK; Jain AK; Muniyappa K; Bhattacharya S
    J Med Chem; 2012 Sep; 55(17):7460-71. PubMed ID: 22827615
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.
    Sparapani S; Haider SM; Doria F; Gunaratnam M; Neidle S
    J Am Chem Soc; 2010 Sep; 132(35):12263-72. PubMed ID: 20718414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
    Wu WB; Chen SH; Hou JQ; Tan JH; Ou TM; Huang SL; Li D; Gu LQ; Huang ZS
    Org Biomol Chem; 2011 Apr; 9(8):2975-86. PubMed ID: 21373680
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
    Moore MJ; Schultes CM; Cuesta J; Cuenca F; Gunaratnam M; Tanious FA; Wilson WD; Neidle S
    J Med Chem; 2006 Jan; 49(2):582-99. PubMed ID: 16420044
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Symmetrical bisbenzimidazoles with benzenediyl spacer: the role of the shape of the ligand on the stabilization and structural alterations in telomeric G-quadruplex DNA and telomerase inhibition.
    Bhattacharya S; Chaudhuri P; Jain AK; Paul A
    Bioconjug Chem; 2010 Jul; 21(7):1148-59. PubMed ID: 20536245
    [TBL] [Abstract][Full Text] [Related]  

  • 9. NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.
    Fedoroff OY; Salazar M; Han H; Chemeris VV; Kerwin SM; Hurley LH
    Biochemistry; 1998 Sep; 37(36):12367-74. PubMed ID: 9730808
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.
    Zhang WJ; Ou TM; Lu YJ; Huang YY; Wu WB; Huang ZS; Zhou JL; Wong KY; Gu LQ
    Bioorg Med Chem; 2007 Aug; 15(16):5493-501. PubMed ID: 17574421
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies on characterization, telomerase inhibitory properties and G-quadruplex binding of η6-arene ruthenium complexes with 1,10-phenanthroline-derived ligands.
    Sun D; Zhang R; Yuan F; Liu D; Zhou Y; Liu J
    Dalton Trans; 2012 Feb; 41(6):1734-41. PubMed ID: 22159049
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands.
    Ma Y; Ou TM; Tan JH; Hou JQ; Huang SL; Gu LQ; Huang ZS
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3414-7. PubMed ID: 19477640
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dinuclear ruthenium(II) complexes that induce and stabilise G-quadruplex DNA.
    Xu L; Chen X; Wu J; Wang J; Ji L; Chao H
    Chemistry; 2015 Mar; 21(10):4008-20. PubMed ID: 25620220
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
    Li Z; Tan JH; He JH; Long Y; Ou TM; Li D; Gu LQ; Huang ZS
    Eur J Med Chem; 2012 Jan; 47(1):299-311. PubMed ID: 22104971
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stabilization of G-quadruplex DNA, inhibition of telomerase activity and live cell imaging studies of chiral ruthenium(II) complexes.
    Sun D; Liu Y; Liu D; Zhang R; Yang X; Liu J
    Chemistry; 2012 Apr; 18(14):4285-95. PubMed ID: 22367788
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.
    Cuenca F; Greciano O; Gunaratnam M; Haider S; Munnur D; Nanjunda R; Wilson WD; Neidle S
    Bioorg Med Chem Lett; 2008 Mar; 18(5):1668-73. PubMed ID: 18243701
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells.
    Maji B; Kumar K; Kaulage M; Muniyappa K; Bhattacharya S
    J Med Chem; 2014 Aug; 57(16):6973-88. PubMed ID: 25062468
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.
    Guyen B; Schultes CM; Hazel P; Mann J; Neidle S
    Org Biomol Chem; 2004 Apr; 2(7):981-8. PubMed ID: 15034620
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders.
    Alcaro S; Artese A; Costa G; Distinto S; Ortuso F; Parrotta L
    Biochimie; 2011 Aug; 93(8):1267-74. PubMed ID: 21699954
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.
    Hampel SM; Sidibe A; Gunaratnam M; Riou JF; Neidle S
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6459-63. PubMed ID: 20932753
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.