95 related articles for article (PubMed ID: 21944747)
1. Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.
Maifeld SV; MacKinnon AL; Garrison JL; Sharma A; Kunkel EJ; Hegde RS; Taunton J
Chem Biol; 2011 Sep; 18(9):1082-8. PubMed ID: 21944747
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents.
Van Puyenbroeck V; Vermeire K
Cell Mol Life Sci; 2018 May; 75(9):1541-1558. PubMed ID: 29305616
[TBL] [Abstract][Full Text] [Related]
3. Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.
Mattos DR; Neves WD; Kitamura T; Pradhan R; Wan X; da Hora CC; Tranter D; Kazemi S; Yu X; Tripathy N; Paavilainen VO; McPhail KL; Oishi S; Badr CE; Ishmael JE
ACS Pharmacol Transl Sci; 2024 Jun; 7(6):1823-1838. PubMed ID: 38898945
[TBL] [Abstract][Full Text] [Related]
4. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
Mackinnon AL; Paavilainen VO; Sharma A; Hegde RS; Taunton J
Elife; 2014; 3():e01483. PubMed ID: 24497544
[TBL] [Abstract][Full Text] [Related]
5. Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.
Junne T; Wong J; Studer C; Aust T; Bauer BW; Beibel M; Bhullar B; Bruccoleri R; Eichenberger J; Estoppey D; Hartmann N; Knapp B; Krastel P; Melin N; Oakeley EJ; Oberer L; Riedl R; Roma G; Schuierer S; Petersen F; Tallarico JA; Rapoport TA; Spiess M; Hoepfner D
J Cell Sci; 2015 Mar; 128(6):1217-29. PubMed ID: 25616894
[TBL] [Abstract][Full Text] [Related]
6. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.
Ruiz-Saenz A; Sandhu M; Carrasco Y; Maglathlin RL; Taunton J; Moasser MM
Oncogene; 2015 Oct; 34(41):5288-94. PubMed ID: 25619841
[TBL] [Abstract][Full Text] [Related]
7. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.
Paatero AO; Kellosalo J; Dunyak BM; Almaliti J; Gestwicki JE; Gerwick WH; Taunton J; Paavilainen VO
Cell Chem Biol; 2016 May; 23(5):561-566. PubMed ID: 27203376
[TBL] [Abstract][Full Text] [Related]
8. Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Conti BJ; Devaraneni PK; Yang Z; David LL; Skach WR
Mol Cell; 2015 Apr; 58(2):269-83. PubMed ID: 25801167
[TBL] [Abstract][Full Text] [Related]
9. Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.
Vermeire K; Bell TW; Van Puyenbroeck V; Giraut A; Noppen S; Liekens S; Schols D; Hartmann E; Kalies KU; Marsh M
PLoS Biol; 2014 Dec; 12(12):e1002011. PubMed ID: 25460167
[TBL] [Abstract][Full Text] [Related]
10. A unifying model for membrane protein biogenesis.
Hegde RS; Keenan RJ
Nat Struct Mol Biol; 2024 May; ():. PubMed ID: 38811793
[TBL] [Abstract][Full Text] [Related]
11. Global signal peptide profiling reveals principles of selective Sec61 inhibition.
Wenzell NA; Tuch BB; McMinn DL; Lyons MJ; Kirk CJ; Taunton J
Nat Chem Biol; 2024 Mar; ():. PubMed ID: 38519575
[TBL] [Abstract][Full Text] [Related]
12. Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S; Tranter D; Sharp PP; Craven GB; Lowe E; Anderl JL; Muchamuel T; Abrishami V; Kuivanen S; Wenzell NA; Jennings A; Kalyanaraman C; Strandin T; Javanainen M; Vapalahti O; Jacobson MP; McMinn D; Kirk CJ; Huiskonen JT; Taunton J; Paavilainen VO
Nat Chem Biol; 2023 Sep; 19(9):1054-1062. PubMed ID: 37169961
[TBL] [Abstract][Full Text] [Related]
13. Mechanism of an intramembrane chaperone for multipass membrane proteins.
Smalinskaitė L; Kim MK; Lewis AJO; Keenan RJ; Hegde RS
Nature; 2022 Nov; 611(7934):161-166. PubMed ID: 36261528
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
Meyer LK; Delgado-Martin C; Sharp PP; Huang BJ; McMinn D; Vincent TL; Ryan T; Horton TM; Wood BL; Teachey DT; Taunton J; Kirk CJ; Hermiston ML
Br J Haematol; 2022 Jul; 198(1):137-141. PubMed ID: 35434798
[TBL] [Abstract][Full Text] [Related]
15. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway.
Pauwels E; Schülein R; Vermeire K
Int J Mol Sci; 2021 Nov; 22(21):. PubMed ID: 34769437
[TBL] [Abstract][Full Text] [Related]
16. Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis.
Roboti P; O'Keefe S; Duah KB; Shi WQ; High S
Sci Rep; 2021 Jun; 11(1):11562. PubMed ID: 34079010
[TBL] [Abstract][Full Text] [Related]
17. Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A.
Kazemi S; Kawaguchi S; Badr CE; Mattos DR; Ruiz-Saenz A; Serrill JD; Moasser MM; Dolan BP; Paavilainen VO; Oishi S; McPhail KL; Ishmael JE
Biochem Pharmacol; 2021 Jan; 183():114317. PubMed ID: 33152346
[TBL] [Abstract][Full Text] [Related]
18. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins.
Tranter D; Paatero AO; Kawaguchi S; Kazemi S; Serrill JD; Kellosalo J; Vogel WK; Richter U; Mattos DR; Wan X; Thornburg CC; Oishi S; McPhail KL; Ishmael JE; Paavilainen VO
ACS Chem Biol; 2020 Aug; 15(8):2125-2136. PubMed ID: 32608972
[TBL] [Abstract][Full Text] [Related]
19.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]