475 related articles for article (PubMed ID: 21949121)
1. Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1.
Huang S; Yang ZJ; Yu C; Sinicrope FA
J Biol Chem; 2011 Nov; 286(46):40002-12. PubMed ID: 21949121
[TBL] [Abstract][Full Text] [Related]
2. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.
Dunlop EA; Hunt DK; Acosta-Jaquez HA; Fingar DC; Tee AR
Autophagy; 2011 Jul; 7(7):737-47. PubMed ID: 21460630
[TBL] [Abstract][Full Text] [Related]
3. The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.
Willems L; Chapuis N; Puissant A; Maciel TT; Green AS; Jacque N; Vignon C; Park S; Guichard S; Herault O; Fricot A; Hermine O; Moura IC; Auberger P; Ifrah N; Dreyfus F; Bonnet D; Lacombe C; Mayeux P; Bouscary D; Tamburini J
Leukemia; 2012 Jun; 26(6):1195-202. PubMed ID: 22143671
[TBL] [Abstract][Full Text] [Related]
4. The association of AMPK with ULK1 regulates autophagy.
Lee JW; Park S; Takahashi Y; Wang HG
PLoS One; 2010 Nov; 5(11):e15394. PubMed ID: 21072212
[TBL] [Abstract][Full Text] [Related]
5. The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells.
Rui YN; Xu Z; Chen Z; Zhang S
Autophagy; 2015; 11(5):812-32. PubMed ID: 25984893
[TBL] [Abstract][Full Text] [Related]
6. Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.
Ito M; Yurube T; Kakutani K; Maeno K; Takada T; Terashima Y; Kakiuchi Y; Takeoka Y; Miyazaki S; Kuroda R; Nishida K
Osteoarthritis Cartilage; 2017 Dec; 25(12):2134-2146. PubMed ID: 28888905
[TBL] [Abstract][Full Text] [Related]
7. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells.
Sini P; James D; Chresta C; Guichard S
Autophagy; 2010 May; 6(4):553-4. PubMed ID: 20364113
[TBL] [Abstract][Full Text] [Related]
8. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.
Aryal P; Kim K; Park PH; Ham S; Cho J; Song K
FEBS J; 2014 Oct; 281(20):4644-58. PubMed ID: 25132405
[TBL] [Abstract][Full Text] [Related]
9. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
Ozturk DG; Kocak M; Akcay A; Kinoglu K; Kara E; Buyuk Y; Kazan H; Gozuacik D
Autophagy; 2019 Mar; 15(3):375-390. PubMed ID: 30290719
[TBL] [Abstract][Full Text] [Related]
10. Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 protein.
Preuss E; Hugle M; Reimann R; Schlecht M; Fulda S
J Biol Chem; 2013 Dec; 288(49):35287-96. PubMed ID: 24133218
[TBL] [Abstract][Full Text] [Related]
11. AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma.
Hu M; Huang H; Zhao R; Li P; Li M; Miao H; Chen N; Chen M
Oncol Rep; 2014 Feb; 31(2):649-56. PubMed ID: 24297300
[TBL] [Abstract][Full Text] [Related]
12. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.
Lim J; Lachenmayer ML; Wu S; Liu W; Kundu M; Wang R; Komatsu M; Oh YJ; Zhao Y; Yue Z
PLoS Genet; 2015; 11(2):e1004987. PubMed ID: 25723488
[TBL] [Abstract][Full Text] [Related]
13. Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells.
Jiang S; Zou Z; Nie P; Wen R; Xiao Y; Tang J
PLoS One; 2015; 10(7):e0132880. PubMed ID: 26176608
[TBL] [Abstract][Full Text] [Related]
14. Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells.
Shi D; Niu P; Heng X; Chen L; Zhu Y; Zhou J
Pharmacol Rep; 2018 Oct; 70(5):908-916. PubMed ID: 30099297
[TBL] [Abstract][Full Text] [Related]
15. ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
Jung CH; Seo M; Otto NM; Kim DH
Autophagy; 2011 Oct; 7(10):1212-21. PubMed ID: 21795849
[TBL] [Abstract][Full Text] [Related]
16. The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Li Q; Song XM; Ji YY; Jiang H; Xu LG
Biochem Biophys Res Commun; 2013 Nov; 440(4):701-6. PubMed ID: 24103749
[TBL] [Abstract][Full Text] [Related]
17. Relieving autophagy and 4EBP1 from rapamycin resistance.
Nyfeler B; Bergman P; Triantafellow E; Wilson CJ; Zhu Y; Radetich B; Finan PM; Klionsky DJ; Murphy LO
Mol Cell Biol; 2011 Jul; 31(14):2867-76. PubMed ID: 21576371
[TBL] [Abstract][Full Text] [Related]
18. Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation.
Guo R; Ren J
Cardiovasc Res; 2012 Jun; 94(3):480-91. PubMed ID: 22451512
[TBL] [Abstract][Full Text] [Related]
19. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
[TBL] [Abstract][Full Text] [Related]
20. Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.
Szymańska P; Martin KR; MacKeigan JP; Hlavacek WS; Lipniacki T
PLoS One; 2015; 10(3):e0116550. PubMed ID: 25761126
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
