BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

427 related articles for article (PubMed ID: 21949132)

  • 1. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
    Wang J; Markova D; Anderson DG; Zheng Z; Shapiro IM; Risbud MV
    J Biol Chem; 2011 Nov; 286(46):39738-49. PubMed ID: 21949132
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bone morphogenetic protein-7 antagonizes tumor necrosis factor-α-induced activation of nuclear factor κB and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II.
    Wang Z; Hutton WC; Yoon ST
    Spine J; 2014 Mar; 14(3):505-12. PubMed ID: 24176808
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.
    Tian Y; Yuan W; Fujita N; Wang J; Wang H; Shapiro IM; Risbud MV
    Am J Pathol; 2013 Jun; 182(6):2310-21. PubMed ID: 23602832
    [TBL] [Abstract][Full Text] [Related]  

  • 4. IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc.
    Sun Z; Yin Z; Liu C; Liang H; Jiang M; Tian J
    J Orthop Surg Res; 2015 Oct; 10():159. PubMed ID: 26438479
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling.
    Fujita N; Gogate SS; Chiba K; Toyama Y; Shapiro IM; Risbud MV
    J Biol Chem; 2012 Nov; 287(47):39942-53. PubMed ID: 22948157
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aggrecanase and aggrecan degradation in osteoarthritis: a review.
    Huang K; Wu LD
    J Int Med Res; 2008; 36(6):1149-60. PubMed ID: 19094423
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Upregulation of tumor necrosis factor α and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes.
    Chen S; Huang Y; Zhou ZJ; Hu ZJ; Wang JY; Xu WB; Fang XQ; Fan SW
    Spine (Phila Pa 1976); 2014 Jun; 39(14):E817-25. PubMed ID: 24732836
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
    Binch ALA; Shapiro IM; Risbud MV
    Matrix Biol; 2016; 52-54():355-362. PubMed ID: 26796346
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc disease.
    Wang X; Wang H; Yang H; Li J; Cai Q; Shapiro IM; Risbud MV
    Am J Pathol; 2014 Sep; 184(9):2560-72. PubMed ID: 25063530
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.
    Li J; Yuan W; Jiang S; Ye W; Yang H; Shapiro IM; Risbud MV
    J Biol Chem; 2015 Mar; 290(11):7195-207. PubMed ID: 25635047
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.
    Boeuf S; Graf F; Fischer J; Moradi B; Little CB; Richter W
    Eur Cell Mater; 2012 May; 23():320-32. PubMed ID: 22562232
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.
    Patel KP; Sandy JD; Akeda K; Miyamoto K; Chujo T; An HS; Masuda K
    Spine (Phila Pa 1976); 2007 Nov; 32(23):2596-603. PubMed ID: 17978660
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
    Wang H; Tian Y; Wang J; Phillips KLE; Binch ALA; Dunn S; Cross A; Chiverton N; Zheng Z; Shapiro IM; Le Maitre CL; Risbud MV
    J Biol Chem; 2013 Jun; 288(23):16761-16774. PubMed ID: 23589286
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.
    Yurube T; Takada T; Suzuki T; Kakutani K; Maeno K; Doita M; Kurosaka M; Nishida K
    Arthritis Res Ther; 2012 Mar; 14(2):R51. PubMed ID: 22394620
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration.
    Erwin WM; Islam D; Inman RD; Fehlings MG; Tsui FW
    Arthritis Res Ther; 2011; 13(6):R215. PubMed ID: 22206702
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
    Ji Q; Zhang Q; Wang Y
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2013 Sep; 27(9):1080-4. PubMed ID: 24279019
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells.
    Fujita N; Hirose Y; Tran CM; Chiba K; Miyamoto T; Toyama Y; Shapiro IM; Risbud MV
    FASEB J; 2014 Jun; 28(6):2455-65. PubMed ID: 24558194
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interleukin-1β exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
    Sun ZY; Liu YT; Liang H; Li Y; Wang DG; Tian JW
    Eur Rev Med Pharmacol Sci; 2018 Nov; 22(21):7129-7139. PubMed ID: 30468453
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of nuclear factor kappa B signaling pathway in human intervertebral disc degeneration.
    Zhongyi S; Sai Z; Chao L; Jiwei T
    Spine (Phila Pa 1976); 2015 Feb; 40(4):224-32. PubMed ID: 25494317
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
    Cross AK; Haddock G; Stock CJ; Allan S; Surr J; Bunning RA; Buttle DJ; Woodroofe MN
    Brain Res; 2006 May; 1088(1):19-30. PubMed ID: 16630594
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.