BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

78 related articles for article (PubMed ID: 21953839)

  • 1. Silicon analogues of the nonpeptidic GnRH antagonist AG-045572: syntheses, crystal structure analyses, and pharmacological characterization.
    Barnes MJ; Burschka C; Büttner MW; Conroy R; Daiss JO; Gray IC; Hendrick AG; Tam LH; Kuehn D; Miller DJ; Mills JS; Mitchell P; Montana JG; Muniandy PA; Rapley H; Showell GA; Tebbe D; Tacke R; Warneck JB; Zhu B
    ChemMedChem; 2011 Nov; 6(11):2070-80. PubMed ID: 21953839
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats.
    Anderes KL; Luthin DR; Castillo R; Kraynov EA; Castro M; Nared-Hood K; Gregory ML; Pathak VP; Christie LC; Paderes G; Vazir H; Ye Q; Anderson MB; May JM
    J Pharmacol Exp Ther; 2003 May; 305(2):688-95. PubMed ID: 12606616
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells.
    Bauer JB; Lippert WP; Dörrich S; Tebbe D; Burschka C; Christie VB; Tams DM; Henderson AP; Murray BA; Marder TB; Przyborski SA; Tacke R
    ChemMedChem; 2011 Aug; 6(8):1509-17. PubMed ID: 21726055
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of SKI2670, a novel, orally active, non-peptide GnRH antagonist, on hypothalamic-pituitary-gonadal axis.
    Kim SM; Yoo T; Lee SY; Kim EJ; Lee SM; Lee MH; Han MY; Jung SH; Choi JH; Ryu KH; Kim HT
    Life Sci; 2015 Oct; 139():166-74. PubMed ID: 26321528
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis, conformation, biodistribution, and hormone-related in vitro antitumor activity of a gonadotropin-releasing hormone antagonist-branched polypeptide conjugate.
    Mezö G; Mezö I; Pimm MV; Kajtár J; Seprödi J; Teplán I; Kovács M; Vincze B; Pályi I; Idei M; Szekerke M; Hudecz F
    Bioconjug Chem; 1996; 7(6):642-50. PubMed ID: 8950483
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist.
    Iatsimirskaia EA; Gregory ML; Anderes KL; Castillo R; Milgram KE; Luthin DR; Pathak VP; Christie LC; Vazir H; Anderson MB; May JM
    Pharm Res; 2002 Feb; 19(2):202-8. PubMed ID: 11883648
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
    Tucci FC; Zhu YF; Struthers RS; Guo Z; Gross TD; Rowbottom MW; Acevedo O; Gao Y; Saunders J; Xie Q; Reinhart GJ; Liu XJ; Ling N; Bonneville AK; Chen T; Bozigian H; Chen C
    J Med Chem; 2005 Feb; 48(4):1169-78. PubMed ID: 15715483
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.
    Sasaki S; Cho N; Nara Y; Harada M; Endo S; Suzuki N; Furuya S; Fujino M
    J Med Chem; 2003 Jan; 46(1):113-24. PubMed ID: 12502365
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.
    Gluyas JB; Burschka C; Dörrich S; Vallet J; Gronemeyer H; Tacke R
    Org Biomol Chem; 2012 Sep; 10(34):6914-29. PubMed ID: 22814352
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists.
    Cui J; Smith RG; Mount GR; Lo JL; Yu J; Walsh TF; Singh SB; DeVita RJ; Goulet MT; Schaeffer JM; Cheng K
    Mol Endocrinol; 2000 May; 14(5):671-81. PubMed ID: 10809231
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
    Randolph JT; Waid P; Nichols C; Sauer D; Haviv F; Diaz G; Bammert G; Besecke LM; Segreti JA; Mohning KM; Bush EN; Wegner CD; Greer J
    J Med Chem; 2004 Feb; 47(5):1085-97. PubMed ID: 14971889
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II.
    Samant MP; Gulyas J; Hong DJ; Croston G; Rivier C; Rivier J
    J Med Chem; 2005 Jul; 48(15):4851-60. PubMed ID: 16033265
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology.
    Büttner MW; Burschka C; Daiss JO; Ivanova D; Rochel N; Kammerer S; Peluso-Iltis C; Bindler A; Gaudon C; Germain P; Moras D; Gronemeyer H; Tacke R
    Chembiochem; 2007 Sep; 8(14):1688-99. PubMed ID: 17768726
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biochemistry, molecular biology and cell biology of gonadotropin-releasing hormone antagonists.
    Tan O; Bukulmez O
    Curr Opin Obstet Gynecol; 2011 Aug; 23(4):238-44. PubMed ID: 21666463
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists.
    Rivier JE; Jiang G; Struthers RS; Koerber SC; Porter J; Cervini LA; Kirby DA; Craig AG; Rivier CL
    J Med Chem; 2000 Mar; 43(5):807-18. PubMed ID: 10715149
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer.
    Steinberg M
    Clin Ther; 2009; 31 Pt 2():2312-31. PubMed ID: 20110043
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of new gonadotrophin-releasing hormone partial agonists.
    Leaños-Miranda A; Ulloa-Aguirre A; Cervini LA; Janovick JA; Rivier J; Conn PM
    J Endocrinol; 2006 Jun; 189(3):509-17. PubMed ID: 16731782
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel gonadotropin-releasing hormone antagonists with substitutions at position 5.
    Samant MP; Hong DJ; Croston G; Rivier C; Rivier J
    Biopolymers; 2005; 80(2-3):386-91. PubMed ID: 15614806
    [TBL] [Abstract][Full Text] [Related]  

  • 19. GnRH-antagonists in reproductive medicine.
    Griesinger G; Felberbaum R; Diedrich K
    Arch Gynecol Obstet; 2005 Dec; 273(2):71-8. PubMed ID: 15991015
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nonsteroidal progesterone receptor ligands (I): synthesis and SAR of new tetrahydronaphthofuranone derivatives.
    Shinei R; Kurihara K; Tanabe K; Tabata Y; Kurata Y; Hoshiko S; Okonogi T
    Bioorg Med Chem; 2006 Jul; 14(14):4850-61. PubMed ID: 16580213
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.