352 related articles for article (PubMed ID: 21956113)
1. Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.
Case N; Thomas J; Sen B; Styner M; Xie Z; Galior K; Rubin J
J Biol Chem; 2011 Nov; 286(45):39450-6. PubMed ID: 21956113
[TBL] [Abstract][Full Text] [Related]
2. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.
Chen CH; Shaikenov T; Peterson TR; Aimbetov R; Bissenbaev AK; Lee SW; Wu J; Lin HK; Sarbassov dos D
Sci Signal; 2011 Feb; 4(161):ra10. PubMed ID: 21343617
[TBL] [Abstract][Full Text] [Related]
3. mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].
Moore SF; Hunter RW; Hers I
J Biol Chem; 2011 Jul; 286(28):24553-60. PubMed ID: 21592956
[TBL] [Abstract][Full Text] [Related]
4. Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Soares HP; Ming M; Mellon M; Young SH; Han L; Sinnet-Smith J; Rozengurt E
Mol Cancer Ther; 2015 Apr; 14(4):1014-23. PubMed ID: 25673820
[TBL] [Abstract][Full Text] [Related]
5. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Julien LA; Carriere A; Moreau J; Roux PP
Mol Cell Biol; 2010 Feb; 30(4):908-21. PubMed ID: 19995915
[TBL] [Abstract][Full Text] [Related]
6. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.
Lee SL; Chou CC; Chuang HC; Hsu EC; Chiu PC; Kulp SK; Byrd JC; Chen CS
PLoS One; 2013; 8(6):e67149. PubMed ID: 23840605
[TBL] [Abstract][Full Text] [Related]
7. Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.
Mottet D; Dumont V; Deccache Y; Demazy C; Ninane N; Raes M; Michiels C
J Biol Chem; 2003 Aug; 278(33):31277-85. PubMed ID: 12764143
[TBL] [Abstract][Full Text] [Related]
8. Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells.
Mariappan MM; Shetty M; Sataranatarajan K; Choudhury GG; Kasinath BS
J Biol Chem; 2008 Nov; 283(45):30566-75. PubMed ID: 18701453
[TBL] [Abstract][Full Text] [Related]
9. mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells.
Sen B; Xie Z; Case N; Thompson WR; Uzer G; Styner M; Rubin J
J Bone Miner Res; 2014 Jan; 29(1):78-89. PubMed ID: 23821483
[TBL] [Abstract][Full Text] [Related]
10. Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.
Glidden EJ; Gray LG; Vemuru S; Li D; Harris TE; Mayo MW
J Biol Chem; 2012 Jan; 287(1):581-588. PubMed ID: 22084251
[TBL] [Abstract][Full Text] [Related]
11. Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
Moore SF; van den Bosch MT; Hunter RW; Sakamoto K; Poole AW; Hers I
J Biol Chem; 2013 Feb; 288(6):3918-28. PubMed ID: 23239877
[TBL] [Abstract][Full Text] [Related]
12. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.
Han EK; Leverson JD; McGonigal T; Shah OJ; Woods KW; Hunter T; Giranda VL; Luo Y
Oncogene; 2007 Aug; 26(38):5655-61. PubMed ID: 17334390
[TBL] [Abstract][Full Text] [Related]
13. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Hresko RC; Mueckler M
J Biol Chem; 2005 Dec; 280(49):40406-16. PubMed ID: 16221682
[TBL] [Abstract][Full Text] [Related]
14. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.
Yuan M; Pino E; Wu L; Kacergis M; Soukas AA
J Biol Chem; 2012 Aug; 287(35):29579-88. PubMed ID: 22773877
[TBL] [Abstract][Full Text] [Related]
15. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
Boulbes D; Chen CH; Shaikenov T; Agarwal NK; Peterson TR; Addona TA; Keshishian H; Carr SA; Magnuson MA; Sabatini DM; Sarbassov dos D
Mol Cancer Res; 2010 Jun; 8(6):896-906. PubMed ID: 20501647
[TBL] [Abstract][Full Text] [Related]
16. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
Singh BK; Sinha RA; Zhou J; Tripathi M; Ohba K; Wang ME; Astapova I; Ghosh S; Hollenberg AN; Gauthier K; Yen PM
J Biol Chem; 2016 Jan; 291(1):198-214. PubMed ID: 26453307
[TBL] [Abstract][Full Text] [Related]
17. Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension.
Houssaini A; Abid S; Mouraret N; Wan F; Rideau D; Saker M; Marcos E; Tissot CM; Dubois-Randé JL; Amsellem V; Adnot S
Am J Respir Cell Mol Biol; 2013 May; 48(5):568-77. PubMed ID: 23470622
[TBL] [Abstract][Full Text] [Related]
18. Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury.
Mariappan MM; Prasad S; D'Silva K; Cedillo E; Sataranatarajan K; Barnes JL; Choudhury GG; Kasinath BS
J Biol Chem; 2014 Dec; 289(51):35363-75. PubMed ID: 25339176
[TBL] [Abstract][Full Text] [Related]
19. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Guertin DA; Stevens DM; Thoreen CC; Burds AA; Kalaany NY; Moffat J; Brown M; Fitzgerald KJ; Sabatini DM
Dev Cell; 2006 Dec; 11(6):859-71. PubMed ID: 17141160
[TBL] [Abstract][Full Text] [Related]
20. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells.
Thompson WR; Guilluy C; Xie Z; Sen B; Brobst KE; Yen SS; Uzer G; Styner M; Case N; Burridge K; Rubin J
Stem Cells; 2013 Nov; 31(11):2528-37. PubMed ID: 23836527
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
