176 related articles for article (PubMed ID: 21958545)
1. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Walsh MJ; Brimacombe KR; Veith H; Bougie JM; Daniel T; Leister W; Cantley LC; Israelsen WJ; Vander Heiden MG; Shen M; Auld DS; Thomas CJ; Boxer MB
Bioorg Med Chem Lett; 2011 Nov; 21(21):6322-7. PubMed ID: 21958545
[TBL] [Abstract][Full Text] [Related]
2. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Anastasiou D; Yu Y; Israelsen WJ; Jiang JK; Boxer MB; Hong BS; Tempel W; Dimov S; Shen M; Jha A; Yang H; Mattaini KR; Metallo CM; Fiske BP; Courtney KD; Malstrom S; Khan TM; Kung C; Skoumbourdis AP; Veith H; Southall N; Walsh MJ; Brimacombe KR; Leister W; Lunt SY; Johnson ZR; Yen KE; Kunii K; Davidson SM; Christofk HR; Austin CP; Inglese J; Harris MH; Asara JM; Stephanopoulos G; Salituro FG; Jin S; Dang L; Auld DS; Park HW; Cantley LC; Thomas CJ; Vander Heiden MG
Nat Chem Biol; 2012 Oct; 8(10):839-47. PubMed ID: 22922757
[TBL] [Abstract][Full Text] [Related]
3. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Jiang JK; Boxer MB; Vander Heiden MG; Shen M; Skoumbourdis AP; Southall N; Veith H; Leister W; Austin CP; Park HW; Inglese J; Cantley LC; Auld DS; Thomas CJ
Bioorg Med Chem Lett; 2010 Jun; 20(11):3387-93. PubMed ID: 20451379
[TBL] [Abstract][Full Text] [Related]
4. Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis.
Zhan C; Yan L; Wang L; Ma J; Jiang W; Zhang Y; Shi Y; Wang Q
PLoS One; 2015; 10(3):e0118663. PubMed ID: 25738776
[TBL] [Abstract][Full Text] [Related]
5. Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers.
Desai S; Ding M; Wang B; Lu Z; Zhao Q; Shaw K; Yung WK; Weinstein JN; Tan M; Yao J
Oncotarget; 2014 Sep; 5(18):8202-10. PubMed ID: 24077665
[TBL] [Abstract][Full Text] [Related]
6. 1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Yacovan A; Ozeri R; Kehat T; Mirilashvili S; Sherman D; Aizikovich A; Shitrit A; Ben-Zeev E; Schutz N; Bohana-Kashtan O; Konson A; Behar V; Becker OM
Bioorg Med Chem Lett; 2012 Oct; 22(20):6460-8. PubMed ID: 22963766
[TBL] [Abstract][Full Text] [Related]
7. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Israelsen WJ; Dayton TL; Davidson SM; Fiske BP; Hosios AM; Bellinger G; Li J; Yu Y; Sasaki M; Horner JW; Burga LN; Xie J; Jurczak MJ; DePinho RA; Clish CB; Jacks T; Kibbey RG; Wulf GM; Di Vizio D; Mills GB; Cantley LC; Vander Heiden MG
Cell; 2013 Oct; 155(2):397-409. PubMed ID: 24120138
[TBL] [Abstract][Full Text] [Related]
8. Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Méndez-Lucas A; Li X; Hu J; Che L; Song X; Jia J; Wang J; Xie C; Driscoll PC; Tschaharganeh DF; Calvisi DF; Yuneva M; Chen X
Cancer Res; 2017 Aug; 77(16):4355-4364. PubMed ID: 28630053
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Boxer MB; Jiang JK; Vander Heiden MG; Shen M; Skoumbourdis AP; Southall N; Veith H; Leister W; Austin CP; Park HW; Inglese J; Cantley LC; Auld DS; Thomas CJ
J Med Chem; 2010 Feb; 53(3):1048-55. PubMed ID: 20017496
[TBL] [Abstract][Full Text] [Related]
10. Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study.
Marciniec K; Rzepka Z; Chrobak E; Boryczka S; Latocha M; Wrześniok D; Beberok A
Molecules; 2023 Mar; 28(6):. PubMed ID: 36985481
[TBL] [Abstract][Full Text] [Related]
11. Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.
Chen M; Zhang J; Manley JL
Cancer Res; 2010 Nov; 70(22):8977-80. PubMed ID: 20978194
[TBL] [Abstract][Full Text] [Related]
12. Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Chaneton B; Hillmann P; Zheng L; Martin ACL; Maddocks ODK; Chokkathukalam A; Coyle JE; Jankevics A; Holding FP; Vousden KH; Frezza C; O'Reilly M; Gottlieb E
Nature; 2012 Nov; 491(7424):458-462. PubMed ID: 23064226
[TBL] [Abstract][Full Text] [Related]
13. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.
Wubben TJ; Pawar M; Weh E; Smith A; Sajjakulnukit P; Zhang L; Dai L; Hager H; Pai MP; Lyssiotis CA; Besirli CG
Sci Rep; 2020 Feb; 10(1):2990. PubMed ID: 32076076
[TBL] [Abstract][Full Text] [Related]
14. Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes.
Park B; Kim JY; Riffey OF; Dowker-Key P; Bruckbauer A; McLoughlin J; Bettaieb A; Donohoe DR
Sci Rep; 2022 May; 12(1):8771. PubMed ID: 35610475
[TBL] [Abstract][Full Text] [Related]
15. Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
Prakasam G; Singh RK; Iqbal MA; Saini SK; Tiku AB; Bamezai RNK
J Biol Chem; 2017 Sep; 292(37):15561-15576. PubMed ID: 28778925
[TBL] [Abstract][Full Text] [Related]
16. Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.
Mukherjee J; Phillips JJ; Zheng S; Wiencke J; Ronen SM; Pieper RO
PLoS One; 2013; 8(2):e57610. PubMed ID: 23451252
[TBL] [Abstract][Full Text] [Related]
17. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.
Bluemlein K; Grüning NM; Feichtinger RG; Lehrach H; Kofler B; Ralser M
Oncotarget; 2011 May; 2(5):393-400. PubMed ID: 21789790
[TBL] [Abstract][Full Text] [Related]
18. Pyruvate kinase: Function, regulation and role in cancer.
Israelsen WJ; Vander Heiden MG
Semin Cell Dev Biol; 2015 Jul; 43():43-51. PubMed ID: 26277545
[TBL] [Abstract][Full Text] [Related]
19. PKM2, cancer metabolism, and the road ahead.
Dayton TL; Jacks T; Vander Heiden MG
EMBO Rep; 2016 Dec; 17(12):1721-1730. PubMed ID: 27856534
[TBL] [Abstract][Full Text] [Related]
20. Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity.
Chen C; Wang T; Wu F; Huang W; He G; Ouyang L; Xiang M; Peng C; Jiang Q
Drug Des Devel Ther; 2014; 8():1195-210. PubMed ID: 25214764
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
