BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

496 related articles for article (PubMed ID: 21965330)

  • 1. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
    Wang RH; Kim HS; Xiao C; Xu X; Gavrilova O; Deng CX
    J Clin Invest; 2011 Nov; 121(11):4477-90. PubMed ID: 21965330
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
    Singh BK; Sinha RA; Zhou J; Tripathi M; Ohba K; Wang ME; Astapova I; Ghosh S; Hollenberg AN; Gauthier K; Yen PM
    J Biol Chem; 2016 Jan; 291(1):198-214. PubMed ID: 26453307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
    Hagiwara A; Cornu M; Cybulski N; Polak P; Betz C; Trapani F; Terracciano L; Heim MH; Rüegg MA; Hall MN
    Cell Metab; 2012 May; 15(5):725-38. PubMed ID: 22521878
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling.
    Yuan Q; Zhang R; Sun M; Guo X; Yang J; Bian W; Xie C; Miao D; Mao L
    J Diabetes Res; 2022; 2022():1755563. PubMed ID: 35132380
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice.
    Tripathy S; Jump DB
    J Lipid Res; 2013 Jan; 54(1):71-84. PubMed ID: 23099444
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
    Zhang C; Wendel AA; Keogh MR; Harris TE; Chen J; Coleman RA
    Proc Natl Acad Sci U S A; 2012 Jan; 109(5):1667-72. PubMed ID: 22307628
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
    Sajan MP; Ivey RA; Lee MC; Farese RV
    J Lipid Res; 2015 Jan; 56(1):70-80. PubMed ID: 25395359
    [TBL] [Abstract][Full Text] [Related]  

  • 8. GdCl3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice.
    Wang Q; Wang N; Dong M; Chen F; Li Z; Chen Y
    Clin Sci (Lond); 2014 Jul; 127(2):91-100. PubMed ID: 24444370
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
    Tang Y; Wallace M; Sanchez-Gurmaches J; Hsiao WY; Li H; Lee PL; Vernia S; Metallo CM; Guertin DA
    Nat Commun; 2016 Apr; 7():11365. PubMed ID: 27098609
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.
    Lu M; Sarruf DA; Li P; Osborn O; Sanchez-Alavez M; Talukdar S; Chen A; Bandyopadhyay G; Xu J; Morinaga H; Dines K; Watkins S; Kaiyala K; Schwartz MW; Olefsky JM
    J Biol Chem; 2013 Apr; 288(15):10722-35. PubMed ID: 23457303
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
    Olson DH; Burrill JS; Kuzmicic J; Hahn WS; Park JM; Kim DH; Bernlohr DA
    Biochem Biophys Res Commun; 2017 Nov; 493(3):1311-1317. PubMed ID: 28986255
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice.
    Aljaylani A; Fluitt M; Piselli A; Shepard BD; Tiwari S; Ecelbarger CM
    Cell Physiol Biochem; 2020 Jul; 54(4):682-695. PubMed ID: 32678535
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver.
    Park JM; Kim TH; Bae JS; Kim MY; Kim KS; Ahn YH
    Biochem Biophys Res Commun; 2010 Dec; 403(3-4):329-34. PubMed ID: 21078299
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
    Liu TY; Shi CX; Gao R; Sun HJ; Xiong XQ; Ding L; Chen Q; Li YH; Wang JJ; Kang YM; Zhu GQ
    Clin Sci (Lond); 2015 Nov; 129(10):839-50. PubMed ID: 26201094
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis.
    Lee YS; Lee EK; Oh HH; Choi CS; Kim S; Jun HS
    J Diabetes Res; 2014; 2014():961732. PubMed ID: 25610880
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling.
    Zhang D; Tong X; Arthurs B; Guha A; Rui L; Kamath A; Inoki K; Yin L
    J Biol Chem; 2014 Sep; 289(37):25925-35. PubMed ID: 25063808
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice.
    De Souza CT; Frederico MJ; da Luz G; Cintra DE; Ropelle ER; Pauli JR; Velloso LA
    J Physiol; 2010 Jun; 588(Pt 12):2239-53. PubMed ID: 20421289
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
    Tao R; Xiong X; Liangpunsakul S; Dong XC
    Diabetes; 2015 Apr; 64(4):1211-23. PubMed ID: 25377878
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells.
    Bumke-Vogt C; Osterhoff MA; Borchert A; Guzman-Perez V; Sarem Z; Birkenfeld AL; Bähr V; Pfeiffer AF
    PLoS One; 2014; 9(8):e104321. PubMed ID: 25136826
    [TBL] [Abstract][Full Text] [Related]  

  • 20. mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.
    Le Bacquer O; Queniat G; Gmyr V; Kerr-Conte J; Lefebvre B; Pattou F
    J Endocrinol; 2013 Jan; 216(1):21-9. PubMed ID: 23092880
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.