These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
321 related articles for article (PubMed ID: 21965623)
1. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Dawson S; Stahl S; Paul N; Barber J; Kenna JG Drug Metab Dispos; 2012 Jan; 40(1):130-8. PubMed ID: 21965623 [TBL] [Abstract][Full Text] [Related]
2. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Hayashi H; Takada T; Suzuki H; Onuki R; Hofmann AF; Sugiyama Y Biochim Biophys Acta; 2005 Dec; 1738(1-3):54-62. PubMed ID: 16332456 [TBL] [Abstract][Full Text] [Related]
3. Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse. Zhang J; He K; Cai L; Chen YC; Yang Y; Shi Q; Woolf TF; Ge W; Guo L; Borlak J; Tong W Chem Biol Interact; 2016 Aug; 255():45-54. PubMed ID: 27000539 [TBL] [Abstract][Full Text] [Related]
4. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Warner DJ; Chen H; Cantin LD; Kenna JG; Stahl S; Walker CL; Noeske T Drug Metab Dispos; 2012 Dec; 40(12):2332-41. PubMed ID: 22961681 [TBL] [Abstract][Full Text] [Related]
5. Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Köck K; Ferslew BC; Netterberg I; Yang K; Urban TJ; Swaan PW; Stewart PW; Brouwer KL Drug Metab Dispos; 2014 Apr; 42(4):665-74. PubMed ID: 24154606 [TBL] [Abstract][Full Text] [Related]
6. Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs. Notenboom S; Weigand KM; Proost JH; van Lipzig MMH; van de Steeg E; van den Broek PHH; Greupink R; Russel FGM; Groothuis GMM Eur J Pharm Sci; 2018 Mar; 115():175-184. PubMed ID: 29309877 [TBL] [Abstract][Full Text] [Related]
7. Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury. Qiu X; Zhang Y; Liu T; Shen H; Xiao Y; Bourner MJ; Pratt JR; Thompson DC; Marathe P; Humphreys WG; Lai Y Mol Pharm; 2016 Apr; 13(4):1206-16. PubMed ID: 26910619 [TBL] [Abstract][Full Text] [Related]
8. Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors. Welch MA; Köck K; Urban TJ; Brouwer KL; Swaan PW Drug Metab Dispos; 2015 May; 43(5):725-34. PubMed ID: 25735837 [TBL] [Abstract][Full Text] [Related]
9. Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. Hirano M; Maeda K; Hayashi H; Kusuhara H; Sugiyama Y J Pharmacol Exp Ther; 2005 Aug; 314(2):876-82. PubMed ID: 15901796 [TBL] [Abstract][Full Text] [Related]
10. A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Morgan RE; van Staden CJ; Chen Y; Kalyanaraman N; Kalanzi J; Dunn RT; Afshari CA; Hamadeh HK Toxicol Sci; 2013 Nov; 136(1):216-41. PubMed ID: 23956101 [TBL] [Abstract][Full Text] [Related]
11. The in silico identification of human bile salt export pump (ABCB11) inhibitors associated with cholestatic drug-induced liver injury. Xi L; Yao J; Wei Y; Wu X; Yao X; Liu H; Li S Mol Biosyst; 2017 Jan; 13(2):417-424. PubMed ID: 28092392 [TBL] [Abstract][Full Text] [Related]
12. In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties. Yucha RW; He K; Shi Q; Cai L; Nakashita Y; Xia CQ; Liao M Toxicol Sci; 2017 Jun; 157(2):487-499. PubMed ID: 28369588 [TBL] [Abstract][Full Text] [Related]
13. Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference. Kenna JG Curr Protoc Toxicol; 2014 Aug; 61():23.7.1-15. PubMed ID: 25104267 [TBL] [Abstract][Full Text] [Related]
14. Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications. Ali I; Khalid S; Stieger B; Brouwer KLR Mol Pharm; 2019 Mar; 16(3):1406-1411. PubMed ID: 30608704 [TBL] [Abstract][Full Text] [Related]
15. A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery. Hafey MJ; Houle R; Tanis KQ; Knemeyer I; Shang J; Chen Q; Baudy A; Monroe J; Sistare FD; Evers R Drug Metab Dispos; 2020 Nov; 48(11):1147-1160. PubMed ID: 32943412 [TBL] [Abstract][Full Text] [Related]
16. Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. Kis E; Ioja E; Nagy T; Szente L; Herédi-Szabó K; Krajcsi P Drug Metab Dispos; 2009 Sep; 37(9):1878-86. PubMed ID: 19520776 [TBL] [Abstract][Full Text] [Related]
17. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Aleo MD; Luo Y; Swiss R; Bonin PD; Potter DM; Will Y Hepatology; 2014 Sep; 60(3):1015-22. PubMed ID: 24799086 [TBL] [Abstract][Full Text] [Related]
18. In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review. Cheng Y; Woolf TF; Gan J; He K Chem Biol Interact; 2016 Aug; 255():23-30. PubMed ID: 26683212 [TBL] [Abstract][Full Text] [Related]
19. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Fattinger K; Funk C; Pantze M; Weber C; Reichen J; Stieger B; Meier PJ Clin Pharmacol Ther; 2001 Apr; 69(4):223-31. PubMed ID: 11309550 [TBL] [Abstract][Full Text] [Related]
20. [Measurement of the transport activities of bile salt export pump using chemiluminescence detection method]. Yamaguchi K; Murai T; Yabuuchi H; Hui SP; Kurosawa T Yakugaku Zasshi; 2010 May; 130(5):755-61. PubMed ID: 20460875 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]