241 related articles for article (PubMed ID: 21965657)
1. The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.
Chen CH; Sarbassov dos D
J Biol Chem; 2011 Nov; 286(46):40386-94. PubMed ID: 21965657
[TBL] [Abstract][Full Text] [Related]
2. Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
Chen CH; Kiyan V; Zhylkibayev AA; Kazyken D; Bulgakova O; Page KE; Bersimbaev RI; Spooner E; Sarbassov DD
J Biol Chem; 2013 Sep; 288(38):27019-27030. PubMed ID: 23928304
[TBL] [Abstract][Full Text] [Related]
3. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
Boulbes D; Chen CH; Shaikenov T; Agarwal NK; Peterson TR; Addona TA; Keshishian H; Carr SA; Magnuson MA; Sabatini DM; Sarbassov dos D
Mol Cancer Res; 2010 Jun; 8(6):896-906. PubMed ID: 20501647
[TBL] [Abstract][Full Text] [Related]
4. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
Woo SY; Kim DH; Jun CB; Kim YM; Haar EV; Lee SI; Hegg JW; Bandhakavi S; Griffin TJ; Kim DH
J Biol Chem; 2007 Aug; 282(35):25604-12. PubMed ID: 17599906
[TBL] [Abstract][Full Text] [Related]
5. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
Yang G; Murashige DS; Humphrey SJ; James DE
Cell Rep; 2015 Aug; 12(6):937-43. PubMed ID: 26235620
[TBL] [Abstract][Full Text] [Related]
6. Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS; Liu D; Facchinetti V; Di Lorenzo A; Sessa WC; Schatz DG; Su B
Mol Cell; 2010 Aug; 39(3):433-43. PubMed ID: 20705244
[TBL] [Abstract][Full Text] [Related]
7. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling.
Tato I; Bartrons R; Ventura F; Rosa JL
J Biol Chem; 2011 Feb; 286(8):6128-42. PubMed ID: 21131356
[TBL] [Abstract][Full Text] [Related]
8. Integrity of mTORC2 is dependent on the rictor Gly-934 site.
Aimbetov R; Chen CH; Bulgakova O; Abetov D; Bissenbaev AK; Bersimbaev RI; Sarbassov DD
Oncogene; 2012 Apr; 31(16):2115-20. PubMed ID: 21909137
[TBL] [Abstract][Full Text] [Related]
9. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Liu P; Gan W; Chin YR; Ogura K; Guo J; Zhang J; Wang B; Blenis J; Cantley LC; Toker A; Su B; Wei W
Cancer Discov; 2015 Nov; 5(11):1194-209. PubMed ID: 26293922
[TBL] [Abstract][Full Text] [Related]
10. Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.
Glidden EJ; Gray LG; Vemuru S; Li D; Harris TE; Mayo MW
J Biol Chem; 2012 Jan; 287(1):581-588. PubMed ID: 22084251
[TBL] [Abstract][Full Text] [Related]
11. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Jacinto E; Facchinetti V; Liu D; Soto N; Wei S; Jung SY; Huang Q; Qin J; Su B
Cell; 2006 Oct; 127(1):125-37. PubMed ID: 16962653
[TBL] [Abstract][Full Text] [Related]
12. SHORT syndrome due to a novel de novo mutation in PRKCE (Protein Kinase Cɛ) impairing TORC2-dependent AKT activation.
Alcantara D; Elmslie F; Tetreault M; Bareke E; Hartley T; ; Majewski J; Boycott K; Innes AM; Dyment DA; O'Driscoll M
Hum Mol Genet; 2017 Oct; 26(19):3713-3721. PubMed ID: 28934384
[TBL] [Abstract][Full Text] [Related]
13. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P; Gan W; Inuzuka H; Lazorchak AS; Gao D; Arojo O; Liu D; Wan L; Zhai B; Yu Y; Yuan M; Kim BM; Shaik S; Menon S; Gygi SP; Lee TH; Asara JM; Manning BD; Blenis J; Su B; Wei W
Nat Cell Biol; 2013 Nov; 15(11):1340-50. PubMed ID: 24161930
[TBL] [Abstract][Full Text] [Related]
14. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
Gulati N; Karsy M; Albert L; Murali R; Jhanwar-Uniyal M
Int J Oncol; 2009 Oct; 35(4):731-40. PubMed ID: 19724909
[TBL] [Abstract][Full Text] [Related]
15. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Wang B; Jie Z; Joo D; Ordureau A; Liu P; Gan W; Guo J; Zhang J; North BJ; Dai X; Cheng X; Bian X; Zhang L; Harper JW; Sun SC; Wei W
Nature; 2017 May; 545(7654):365-369. PubMed ID: 28489822
[TBL] [Abstract][Full Text] [Related]
16. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Wang JQ; Chen JH; Chen YC; Chen MY; Hsieh CY; Teng SC; Wu KJ
PLoS One; 2013; 8(6):e65586. PubMed ID: 23762398
[TBL] [Abstract][Full Text] [Related]
17. SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas.
Moraitis D; Karanikou M; Liakou C; Dimas K; Tzimas G; Tseleni-Balafouta S; Patsouris E; Rassidakis GZ; Kouvaraki MA
Surgery; 2014 Dec; 156(6):1542-8; discussion 1548-9. PubMed ID: 25456951
[TBL] [Abstract][Full Text] [Related]
18. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Yang Q; Inoki K; Ikenoue T; Guan KL
Genes Dev; 2006 Oct; 20(20):2820-32. PubMed ID: 17043309
[TBL] [Abstract][Full Text] [Related]
19. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Julien LA; Carriere A; Moreau J; Roux PP
Mol Cell Biol; 2010 Feb; 30(4):908-21. PubMed ID: 19995915
[TBL] [Abstract][Full Text] [Related]
20. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
García-Martínez JM; Alessi DR
Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
