BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 21969008)

  • 1. Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
    Antoniades C; Cunnington C; Antonopoulos A; Neville M; Margaritis M; Demosthenous M; Bendall J; Hale A; Cerrato R; Tousoulis D; Bakogiannis C; Marinou K; Toutouza M; Vlachopoulos C; Leeson P; Stefanadis C; Karpe F; Channon KM
    Circulation; 2011 Oct; 124(17):1860-70. PubMed ID: 21969008
    [TBL] [Abstract][Full Text] [Related]  

  • 2. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
    Antoniades C; Shirodaria C; Van Assche T; Cunnington C; Tegeder I; Lötsch J; Guzik TJ; Leeson P; Diesch J; Tousoulis D; Stefanadis C; Costigan M; Woolf CJ; Alp NJ; Channon KM
    J Am Coll Cardiol; 2008 Jul; 52(2):158-65. PubMed ID: 18598896
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
    Chuaiphichai S; McNeill E; Douglas G; Crabtree MJ; Bendall JK; Hale AB; Alp NJ; Channon KM
    Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
    Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM
    Arterioscler Thromb Vasc Biol; 2004 Mar; 24(3):445-50. PubMed ID: 14707037
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
    Huang A; Zhang YY; Chen K; Hatakeyama K; Keaney JF
    Circ Res; 2005 Feb; 96(2):164-71. PubMed ID: 15604419
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
    Ali ZA; Bursill CA; Douglas G; McNeill E; Papaspyridonos M; Tatham AL; Bendall JK; Akhtar AM; Alp NJ; Greaves DR; Channon KM
    Circulation; 2008 Sep; 118(14 Suppl):S71-7. PubMed ID: 18824773
    [TBL] [Abstract][Full Text] [Related]  

  • 7. GTP cyclohydrolase I mRNA induction and tetrahydrobiopterin synthesis in human endothelial cells.
    Hattori Y; Nakanishi N; Kasai K; Shimoda SI
    Biochim Biophys Acta; 1997 Aug; 1358(1):61-6. PubMed ID: 9296522
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
    Ishii M; Shimizu S; Shiota K; Yamamoto S; Kiuchi Y; Yamamoto T
    Int J Biochem Cell Biol; 2002 Sep; 34(9):1134-41. PubMed ID: 12009308
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
    Chuaiphichai S; Crabtree MJ; Mcneill E; Hale AB; Trelfa L; Channon KM; Douglas G
    Br J Pharmacol; 2017 Apr; 174(8):657-671. PubMed ID: 28128438
    [TBL] [Abstract][Full Text] [Related]  

  • 10. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
    Tegeder I; Costigan M; Griffin RS; Abele A; Belfer I; Schmidt H; Ehnert C; Nejim J; Marian C; Scholz J; Wu T; Allchorne A; Diatchenko L; Binshtok AM; Goldman D; Adolph J; Sama S; Atlas SJ; Carlezon WA; Parsegian A; Lötsch J; Fillingim RB; Maixner W; Geisslinger G; Max MB; Woolf CJ
    Nat Med; 2006 Nov; 12(11):1269-77. PubMed ID: 17057711
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
    Cai S; Khoo J; Channon KM
    Cardiovasc Res; 2005 Mar; 65(4):823-31. PubMed ID: 15721862
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
    Douglas G; Hale AB; Patel J; Chuaiphichai S; Al Haj Zen A; Rashbrook VS; Trelfa L; Crabtree MJ; McNeill E; Channon KM
    Cardiovasc Res; 2018 Aug; 114(10):1385-1399. PubMed ID: 29596571
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
    Zheng JS; Yang XQ; Lookingland KJ; Fink GD; Hesslinger C; Kapatos G; Kovesdi I; Chen AF
    Circulation; 2003 Sep; 108(10):1238-45. PubMed ID: 12925450
    [TBL] [Abstract][Full Text] [Related]  

  • 14. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
    Cai S; Alp NJ; McDonald D; Smith I; Kay J; Canevari L; Heales S; Channon KM
    Cardiovasc Res; 2002 Sep; 55(4):838-49. PubMed ID: 12176133
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
    Hussein D; Starr A; Heikal L; McNeill E; Channon KM; Brown PR; Sutton BJ; McDonnell JM; Nandi M
    Br J Pharmacol; 2015 Aug; 172(16):4146-57. PubMed ID: 26014146
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ionizing radiation induces BH
    Yan T; Zhang T; Mu W; Qi Y; Guo S; Hu N; Zhao W; Zhang S; Wang Q; Shi L; Liu L
    Biochem Pharmacol; 2020 Oct; 180():114102. PubMed ID: 32562786
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
    Antoniades C; Shirodaria C; Crabtree M; Rinze R; Alp N; Cunnington C; Diesch J; Tousoulis D; Stefanadis C; Leeson P; Ratnatunga C; Pillai R; Channon KM
    Circulation; 2007 Dec; 116(24):2851-9. PubMed ID: 18040031
    [TBL] [Abstract][Full Text] [Related]  

  • 18. HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.
    Hattori Y; Nakanishi N; Akimoto K; Yoshida M; Kasai K
    Arterioscler Thromb Vasc Biol; 2003 Feb; 23(2):176-82. PubMed ID: 12588756
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
    McNeill E; Crabtree MJ; Sahgal N; Patel J; Chuaiphichai S; Iqbal AJ; Hale AB; Greaves DR; Channon KM
    Free Radic Biol Med; 2015 Feb; 79():206-16. PubMed ID: 25451639
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta.
    Shimizu S; Ishii M; Kawakami Y; Kiuchi Y; Momose K; Yamamoto T
    Life Sci; 1999; 65(26):2769-79. PubMed ID: 10622266
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.