These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 21971045)

  • 1. Phosphatidylserine binding is essential for plasma membrane recruitment and signaling function of 3-phosphoinositide-dependent kinase-1.
    Lucas N; Cho W
    J Biol Chem; 2011 Dec; 286(48):41265-41272. PubMed ID: 21971045
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
    Ding Z; Liang J; Li J; Lu Y; Ariyaratna V; Lu Z; Davies MA; Westwick JK; Mills GB
    PLoS One; 2010 Mar; 5(3):e9910. PubMed ID: 20361045
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
    Kim S; Jee K; Kim D; Koh H; Chung J
    J Biol Chem; 2001 Apr; 276(16):12864-70. PubMed ID: 11278269
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.
    Seong HA; Jung H; Manoharan R; Ha H
    J Biol Chem; 2012 Jun; 287(25):20811-22. PubMed ID: 22544756
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
    Currie RA; Walker KS; Gray A; Deak M; Casamayor A; Downes CP; Cohen P; Alessi DR; Lucocq J
    Biochem J; 1999 Feb; 337 ( Pt 3)(Pt 3):575-83. PubMed ID: 9895304
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
    Bayascas JR; Wullschleger S; Sakamoto K; García-Martínez JM; Clacher C; Komander D; van Aalten DM; Boini KM; Lang F; Lipina C; Logie L; Sutherland C; Chudek JA; van Diepen JA; Voshol PJ; Lucocq JM; Alessi DR
    Mol Cell Biol; 2008 May; 28(10):3258-72. PubMed ID: 18347057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain.
    Manna D; Bhardwaj N; Vora MS; Stahelin RV; Lu H; Cho W
    J Biol Chem; 2008 Sep; 283(38):26047-58. PubMed ID: 18621733
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.
    Kikani CK; Verona EV; Ryu J; Shen Y; Ye Q; Zheng L; Qian Z; Sakaue H; Nakamura K; Du J; Ji Q; Ogawa W; Sun LZ; Dong LQ; Liu F
    Sci Signal; 2012 Nov; 5(249):ra80. PubMed ID: 23131847
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.
    Masters TA; Calleja V; Armoogum DA; Marsh RJ; Applebee CJ; Laguerre M; Bain AJ; Larijani B
    Sci Signal; 2010 Oct; 3(145):ra78. PubMed ID: 20978239
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.
    Wick MJ; Dong LQ; Riojas RA; Ramos FJ; Liu F
    J Biol Chem; 2000 Dec; 275(51):40400-6. PubMed ID: 11006271
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.
    Bayascas JR
    Cell Cycle; 2008 Oct; 7(19):2978-82. PubMed ID: 18802401
    [TBL] [Abstract][Full Text] [Related]  

  • 12. PDK1 controls upstream PI3K expression and PIP3 generation.
    Dieterle AM; Böhler P; Keppeler H; Alers S; Berleth N; Drießen S; Hieke N; Pietkiewicz S; Löffler AS; Peter C; Gray A; Leslie NR; Shinohara H; Kurosaki T; Engelke M; Wienands J; Bonin M; Wesselborg S; Stork B
    Oncogene; 2014 Jun; 33(23):3043-53. PubMed ID: 23893244
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.
    Seong HA; Jung H; Ichijo H; Ha H
    J Biol Chem; 2010 Jan; 285(4):2397-414. PubMed ID: 19920149
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
    Zurashvili T; Cordón-Barris L; Ruiz-Babot G; Zhou X; Lizcano JM; Gómez N; Giménez-Llort L; Bayascas JR
    Mol Cell Biol; 2013 Mar; 33(5):1027-40. PubMed ID: 23275438
    [TBL] [Abstract][Full Text] [Related]  

  • 15. IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
    Guo JP; Coppola D; Cheng JQ
    J Biol Chem; 2011 Oct; 286(43):37389-98. PubMed ID: 21908616
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.
    Filippa N; Sable CL; Hemmings BA; Van Obberghen E
    Mol Cell Biol; 2000 Aug; 20(15):5712-21. PubMed ID: 10891507
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
    Liao XH; Buggey J; Kimmel AR
    J Cell Sci; 2010 Mar; 123(Pt 6):983-92. PubMed ID: 20200230
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
    Ivetac I; Munday AD; Kisseleva MV; Zhang XM; Luff S; Tiganis T; Whisstock JC; Rowe T; Majerus PW; Mitchell CA
    Mol Biol Cell; 2005 May; 16(5):2218-33. PubMed ID: 15716355
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane.
    Huang BX; Lee R; Akbar M; Kim HY
    Int J Biochem Cell Biol; 2015 Jul; 64():195-201. PubMed ID: 25912234
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).
    Caohuy H; Yang Q; Eudy Y; Ha TA; Xu AE; Glover M; Frizzell RA; Jozwik C; Pollard HB
    J Biol Chem; 2014 Dec; 289(52):35953-68. PubMed ID: 25384981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.