378 related articles for article (PubMed ID: 21984578)
1. PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.
Santin I; Moore F; Colli ML; Gurzov EN; Marselli L; Marchetti P; Eizirik DL
Diabetes; 2011 Dec; 60(12):3279-88. PubMed ID: 21984578
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death.
Roca-Rivada A; Marín-Cañas S; Colli ML; Vinci C; Sawatani T; Marselli L; Cnop M; Marchetti P; Eizirik DL
Diabetologia; 2023 Aug; 66(8):1544-1556. PubMed ID: 36988639
[TBL] [Abstract][Full Text] [Related]
3. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.
Nogueira TC; Paula FM; Villate O; Colli ML; Moura RF; Cunha DA; Marselli L; Marchetti P; Cnop M; Julier C; Eizirik DL
PLoS Genet; 2013 May; 9(5):e1003532. PubMed ID: 23737756
[TBL] [Abstract][Full Text] [Related]
4. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Moore F; Colli ML; Cnop M; Esteve MI; Cardozo AK; Cunha DA; Bugliani M; Marchetti P; Eizirik DL
Diabetes; 2009 Jun; 58(6):1283-91. PubMed ID: 19336676
[TBL] [Abstract][Full Text] [Related]
5. BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.
Marroquí L; Santin I; Dos Santos RS; Marselli L; Marchetti P; Eizirik DL
Diabetes; 2014 Jul; 63(7):2516-27. PubMed ID: 24608439
[TBL] [Abstract][Full Text] [Related]
6. Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
Barthson J; Germano CM; Moore F; Maida A; Drucker DJ; Marchetti P; Gysemans C; Mathieu C; Nuñez G; Jurisicova A; Eizirik DL; Gurzov EN
J Biol Chem; 2011 Nov; 286(45):39632-43. PubMed ID: 21937453
[TBL] [Abstract][Full Text] [Related]
7. MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
Colli ML; Moore F; Gurzov EN; Ortis F; Eizirik DL
Hum Mol Genet; 2010 Jan; 19(1):135-46. PubMed ID: 19825843
[TBL] [Abstract][Full Text] [Related]
8. Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
Colli ML; Nogueira TC; Allagnat F; Cunha DA; Gurzov EN; Cardozo AK; Roivainen M; Op de Beeck A; Eizirik DL
PLoS Pathog; 2011 Sep; 7(9):e1002267. PubMed ID: 21977009
[TBL] [Abstract][Full Text] [Related]
9. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.
McKenzie MD; Jamieson E; Jansen ES; Scott CL; Huang DC; Bouillet P; Allison J; Kay TW; Strasser A; Thomas HE
Diabetes; 2010 Mar; 59(3):644-52. PubMed ID: 19959756
[TBL] [Abstract][Full Text] [Related]
10. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.
Santin I; Moore F; Grieco FA; Marchetti P; Brancolini C; Eizirik DL
Cell Death Dis; 2012 Nov; 3(11):e419. PubMed ID: 23152055
[TBL] [Abstract][Full Text] [Related]
11. FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.
Shukla S; Rizvi F; Raisuddin S; Kakkar P
Free Radic Biol Med; 2014 Nov; 76():185-99. PubMed ID: 25128467
[TBL] [Abstract][Full Text] [Related]
12. Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency.
Ren D; Sun J; Wang C; Ye H; Mao L; Cheng EH; Bell GI; Polonsky KS
Diabetes; 2014 Aug; 63(8):2744-50. PubMed ID: 24658302
[TBL] [Abstract][Full Text] [Related]
13. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.
Wali JA; Rondas D; McKenzie MD; Zhao Y; Elkerbout L; Fynch S; Gurzov EN; Akira S; Mathieu C; Kay TW; Overbergh L; Strasser A; Thomas HE
Cell Death Dis; 2014 Mar; 5(3):e1124. PubMed ID: 24625983
[TBL] [Abstract][Full Text] [Related]
14. Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.
Miani M; Barthson J; Colli ML; Brozzi F; Cnop M; Eizirik DL
Cell Death Dis; 2013 Jul; 4(7):e701. PubMed ID: 23828564
[TBL] [Abstract][Full Text] [Related]
15. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
Kazi A; Sun J; Doi K; Sung SS; Takahashi Y; Yin H; Rodriguez JM; Becerril J; Berndt N; Hamilton AD; Wang HG; Sebti SM
J Biol Chem; 2011 Mar; 286(11):9382-92. PubMed ID: 21148306
[TBL] [Abstract][Full Text] [Related]
16. PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes.
Elvira B; Vandenbempt V; Bauzá-Martinez J; Crutzen R; Negueruela J; Ibrahim H; Winder ML; Brahma MK; Vekeriotaite B; Martens PJ; Singh SP; Rossello F; Lybaert P; Otonkoski T; Gysemans C; Wu W; Gurzov EN
Diabetes; 2022 Apr; 71(4):653-668. PubMed ID: 35044456
[TBL] [Abstract][Full Text] [Related]
17. Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis.
Zhang L; Xing D; Chen M
Apoptosis; 2008 Jul; 13(7):950-8. PubMed ID: 18500555
[TBL] [Abstract][Full Text] [Related]
18. The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor.
Gomez JA; Sun W; Gama V; Hajkova D; Yoshida T; Wu Z; Miyagi M; Pink JJ; Jackson MW; Danielpour D; Matsuyama S
Cancer Biol Ther; 2009 Sep; 8(18):1771-86. PubMed ID: 19657228
[TBL] [Abstract][Full Text] [Related]
19. p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.
Gurzov EN; Germano CM; Cunha DA; Ortis F; Vanderwinden JM; Marchetti P; Zhang L; Eizirik DL
J Biol Chem; 2010 Jun; 285(26):19910-20. PubMed ID: 20421300
[TBL] [Abstract][Full Text] [Related]
20. Involvement of Bim in Photofrin-mediated photodynamically induced apoptosis.
Wang X; He X; Hu S; Sun A; Lu C
Cell Physiol Biochem; 2015; 35(4):1527-36. PubMed ID: 25791936
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
