These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 21984825)

  • 1. In vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production.
    Hands S; Sajjad MU; Newton MJ; Wyttenbach A
    J Biol Chem; 2011 Dec; 286(52):44512-20. PubMed ID: 21984825
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin.
    Burke KA; Kauffman KJ; Umbaugh CS; Frey SL; Legleiter J
    J Biol Chem; 2013 May; 288(21):14993-5005. PubMed ID: 23572526
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
    Kvam E; Nannenga BL; Wang MS; Jia Z; Sierks MR; Messer A
    PLoS One; 2009 May; 4(5):e5727. PubMed ID: 19492089
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.
    Wyttenbach A; Sauvageot O; Carmichael J; Diaz-Latoud C; Arrigo AP; Rubinsztein DC
    Hum Mol Genet; 2002 May; 11(9):1137-51. PubMed ID: 11978772
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aggregation of expanded huntingtin in the brains of patients with Huntington disease.
    Hoffner G; Souès S; Djian P
    Prion; 2007; 1(1):26-31. PubMed ID: 19172113
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
    Aiken CT; Steffan JS; Guerrero CM; Khashwji H; Lukacsovich T; Simmons D; Purcell JM; Menhaji K; Zhu YZ; Green K; Laferla F; Huang L; Thompson LM; Marsh JL
    J Biol Chem; 2009 Oct; 284(43):29427-36. PubMed ID: 19710014
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.
    Dehay B; Bertolotti A
    J Biol Chem; 2006 Nov; 281(47):35608-15. PubMed ID: 16973603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.
    Lakhani VV; Ding F; Dokholyan NV
    PLoS Comput Biol; 2010 Apr; 6(4):e1000772. PubMed ID: 20442863
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.
    Legleiter J; Lotz GP; Miller J; Ko J; Ng C; Williams GL; Finkbeiner S; Patterson PH; Muchowski PJ
    J Biol Chem; 2009 Aug; 284(32):21647-58. PubMed ID: 19491400
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.
    Huang CC; Faber PW; Persichetti F; Mittal V; Vonsattel JP; MacDonald ME; Gusella JF
    Somat Cell Mol Genet; 1998 Jul; 24(4):217-33. PubMed ID: 10410676
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.
    Nucifora LG; Burke KA; Feng X; Arbez N; Zhu S; Miller J; Yang G; Ratovitski T; Delannoy M; Muchowski PJ; Finkbeiner S; Legleiter J; Ross CA; Poirier MA
    J Biol Chem; 2012 May; 287(19):16017-28. PubMed ID: 22433867
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Neurodegenerative disease: neuron protection agency.
    Orr HT
    Nature; 2004 Oct; 431(7010):747-8. PubMed ID: 15483586
    [No Abstract]   [Full Text] [Related]  

  • 13. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody.
    Colby DW; Chu Y; Cassady JP; Duennwald M; Zazulak H; Webster JM; Messer A; Lindquist S; Ingram VM; Wittrup KD
    Proc Natl Acad Sci U S A; 2004 Dec; 101(51):17616-21. PubMed ID: 15598740
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment.
    Persichetti F; Trettel F; Huang CC; Fraefel C; Timmers HT; Gusella JF; MacDonald ME
    Neurobiol Dis; 1999 Oct; 6(5):364-75. PubMed ID: 10527804
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.
    Weiss KR; Kimura Y; Lee WC; Littleton JT
    Genetics; 2012 Feb; 190(2):581-600. PubMed ID: 22095086
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
    Arrasate M; Mitra S; Schweitzer ES; Segal MR; Finkbeiner S
    Nature; 2004 Oct; 431(7010):805-10. PubMed ID: 15483602
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nucleation of huntingtin aggregation in cells.
    Wetzel R
    Nat Chem Biol; 2006 Jun; 2(6):297-8. PubMed ID: 16710335
    [No Abstract]   [Full Text] [Related]  

  • 18. A cellular model that recapitulates major pathogenic steps of Huntington's disease.
    Lunkes A; Mandel JL
    Hum Mol Genet; 1998 Sep; 7(9):1355-61. PubMed ID: 9700187
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro.
    Ermak G; Hench KJ; Chang KT; Sachdev S; Davies KJ
    J Biol Chem; 2009 May; 284(18):11845-53. PubMed ID: 19270310
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biologically active molecules that reduce polyglutamine aggregation and toxicity.
    Desai UA; Pallos J; Ma AA; Stockwell BR; Thompson LM; Marsh JL; Diamond MI
    Hum Mol Genet; 2006 Jul; 15(13):2114-24. PubMed ID: 16720620
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.