158 related articles for article (PubMed ID: 21990269)
1. Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease.
Bartolini M; Pistolozzi M; Andrisano V; Egea J; López MG; Iriepa I; Moraleda I; Gálvez E; Marco-Contelles J; Samadi A
ChemMedChem; 2011 Nov; 6(11):1990-7. PubMed ID: 21990269
[No Abstract] [Full Text] [Related]
2. Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
de Los Ríos C; Egea J; Marco-Contelles J; León R; Samadi A; Iriepa I; Moraleda I; Gálvez E; García AG; López MG; Villarroya M; Romero A
J Med Chem; 2010 Jul; 53(14):5129-43. PubMed ID: 20575555
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
Luo W; Li YP; He Y; Huang SL; Li D; Gu LQ; Huang ZS
Eur J Med Chem; 2011 Jun; 46(6):2609-16. PubMed ID: 21497959
[TBL] [Abstract][Full Text] [Related]
4. Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Di Pietro O; Pérez-Areales FJ; Juárez-Jiménez J; Espargaró A; Clos MV; Pérez B; Lavilla R; Sabaté R; Luque FJ; Muñoz-Torrero D
Eur J Med Chem; 2014 Sep; 84():107-17. PubMed ID: 25016233
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Huang L; Su T; Shan W; Luo Z; Sun Y; He F; Li X
Bioorg Med Chem; 2012 May; 20(9):3038-48. PubMed ID: 22472046
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Chao X; He X; Yang Y; Zhou X; Jin M; Liu S; Cheng Z; Liu P; Wang Y; Yu J; Tan Y; Huang Y; Qin J; Rapposelli S; Pi R
Bioorg Med Chem Lett; 2012 Oct; 22(20):6498-502. PubMed ID: 22981331
[TBL] [Abstract][Full Text] [Related]
7. Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.
Minarini A; Milelli A; Tumiatti V; Rosini M; Simoni E; Bolognesi ML; Andrisano V; Bartolini M; Motori E; Angeloni C; Hrelia S
Neuropharmacology; 2012 Feb; 62(2):997-1003. PubMed ID: 22032870
[TBL] [Abstract][Full Text] [Related]
8. Molecular perception of interactions between bis(7)tacrine and cystamine-tacrine dimer with cholinesterases as the promising proposed agents for the treatment of Alzheimer's disease.
Eslami M; Hashemianzadeh SM; Bagherzadeh K; Seyed Sajadi SA
J Biomol Struct Dyn; 2016; 34(4):855-69. PubMed ID: 26043757
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
Keri RS; Quintanova C; Marques SM; Esteves AR; Cardoso SM; Santos MA
Bioorg Med Chem; 2013 Aug; 21(15):4559-69. PubMed ID: 23768661
[TBL] [Abstract][Full Text] [Related]
10. Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Fernández-Bachiller MI; Pérez C; González-Muñoz GC; Conde S; López MG; Villarroya M; García AG; Rodríguez-Franco MI
J Med Chem; 2010 Jul; 53(13):4927-37. PubMed ID: 20545360
[TBL] [Abstract][Full Text] [Related]
11. O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
Mao F; Huang L; Luo Z; Liu A; Lu C; Xie Z; Li X
Bioorg Med Chem; 2012 Oct; 20(19):5884-92. PubMed ID: 22944335
[TBL] [Abstract][Full Text] [Related]
12. Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
Benchekroun M; Bartolini M; Egea J; Romero A; Soriano E; Pudlo M; Luzet V; Andrisano V; Jimeno ML; López MG; Wehle S; Gharbi T; Refouvelet B; de Andrés L; Herrera-Arozamena C; Monti B; Bolognesi ML; Rodríguez-Franco MI; Decker M; Marco-Contelles J; Ismaili L
ChemMedChem; 2015 Mar; 10(3):523-39. PubMed ID: 25537267
[TBL] [Abstract][Full Text] [Related]
13. Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.
Li SY; Wang XB; Xie SS; Jiang N; Wang KD; Yao HQ; Sun HB; Kong LY
Eur J Med Chem; 2013 Nov; 69():632-46. PubMed ID: 24095756
[TBL] [Abstract][Full Text] [Related]
14. Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload.
Wang Y; Wang F; Yu JP; Jiang FC; Guan XL; Wang CM; Li L; Cao H; Li MX; Chen JG
Bioorg Med Chem; 2012 Nov; 20(21):6513-22. PubMed ID: 23000296
[TBL] [Abstract][Full Text] [Related]
15. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Marco-Contelles J; León R; de los Ríos C; Samadi A; Bartolini M; Andrisano V; Huertas O; Barril X; Luque FJ; Rodríguez-Franco MI; López B; López MG; García AG; Carreiras Mdo C; Villarroya M
J Med Chem; 2009 May; 52(9):2724-32. PubMed ID: 19374444
[TBL] [Abstract][Full Text] [Related]
16. Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
Fernández-Bachiller MI; Pérez C; Campillo NE; Páez JA; González-Muñoz GC; Usán P; García-Palomero E; López MG; Villarroya M; García AG; Martínez A; Rodríguez-Franco MI
ChemMedChem; 2009 May; 4(5):828-41. PubMed ID: 19308922
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Shao D; Zou C; Luo C; Tang X; Li Y
Bioorg Med Chem Lett; 2004 Sep; 14(18):4639-42. PubMed ID: 15324879
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.
Luo W; Li YP; He Y; Huang SL; Tan JH; Ou TM; Li D; Gu LQ; Huang ZS
Bioorg Med Chem; 2011 Jan; 19(2):763-70. PubMed ID: 21211982
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
Dgachi Y; Ismaili L; Knez D; Benchekroun M; Martin H; Szałaj N; Wehle S; Bautista-Aguilera OM; Luzet V; Bonnet A; Malawska B; Gobec S; Chioua M; Decker M; Chabchoub F; Marco-Contelles J
ChemMedChem; 2016 Jun; 11(12):1318-27. PubMed ID: 26804623
[TBL] [Abstract][Full Text] [Related]
20. The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.
Rosini M; Simoni E; Bartolini M; Soriano E; Marco-Contelles J; Andrisano V; Monti B; Windisch M; Hutter-Paier B; McClymont DW; Mellor IR; Bolognesi ML
ChemMedChem; 2013 Aug; 8(8):1276-81. PubMed ID: 23824986
[No Abstract] [Full Text] [Related]
[Next] [New Search]
