These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

193 related articles for article (PubMed ID: 21990269)

  • 41. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
    Rosini M; Simoni E; Bartolini M; Tarozzi A; Matera R; Milelli A; Hrelia P; Andrisano V; Bolognesi ML; Melchiorre C
    Eur J Med Chem; 2011 Nov; 46(11):5435-42. PubMed ID: 21924801
    [TBL] [Abstract][Full Text] [Related]  

  • 42. New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.
    Luo XT; Wang CM; Liu Y; Huang ZG
    Eur J Med Chem; 2015 Oct; 103():302-11. PubMed ID: 26363866
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
    Nachon F; Carletti E; Ronco C; Trovaslet M; Nicolet Y; Jean L; Renard PY
    Biochem J; 2013 Aug; 453(3):393-9. PubMed ID: 23679855
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
    Muñoz-Ruiz P; Rubio L; García-Palomero E; Dorronsoro I; del Monte-Millán M; Valenzuela R; Usán P; de Austria C; Bartolini M; Andrisano V; Bidon-Chanal A; Orozco M; Luque FJ; Medina M; Martínez A
    J Med Chem; 2005 Nov; 48(23):7223-33. PubMed ID: 16279781
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease.
    Matharu B; El-Agnaf O; Razvi A; Austen BM
    Peptides; 2010 Oct; 31(10):1866-72. PubMed ID: 20633587
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
    Sun Y; Chen J; Chen X; Huang L; Li X
    Bioorg Med Chem; 2013 Dec; 21(23):7406-17. PubMed ID: 24128814
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Editorial: Multi-target Drug Discovery - Part I.
    Chen JN
    Curr Top Med Chem; 2017; 17(27):2997-2999. PubMed ID: 29113592
    [No Abstract]   [Full Text] [Related]  

  • 48. Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
    Korabecny J; Musilek K; Holas O; Nepovimova E; Jun D; Zemek F; Opletalova V; Patocka J; Dohnal V; Nachon F; Hroudova J; Fisar Z; Kuca K
    Molecules; 2010 Dec; 15(12):8804-12. PubMed ID: 21127466
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
    Samadi A; Marco-Contelles J; Soriano E; Alvarez-Pérez M; Chioua M; Romero A; González-Lafuente L; Gandía L; Roda JM; López MG; Villarroya M; García AG; Ríos Cde L
    Bioorg Med Chem; 2010 Aug; 18(16):5861-72. PubMed ID: 20656495
    [TBL] [Abstract][Full Text] [Related]  

  • 50. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques.
    Elsinghorst PW; Härtig W; Goldhammer S; Grosche J; Gütschow M
    Org Biomol Chem; 2009 Oct; 7(19):3940-6. PubMed ID: 19763296
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug.
    Chand K; Rajeshwari ; Candeias E; Cardoso SM; Chaves S; Santos MA
    Metallomics; 2018 Oct; 10(10):1460-1475. PubMed ID: 30183790
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    Tang H; Zhao LZ; Zhao HT; Huang SL; Zhong SM; Qin JK; Chen ZF; Huang ZS; Liang H
    Eur J Med Chem; 2011 Oct; 46(10):4970-9. PubMed ID: 21871694
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
    Larbanoix L; Burtea C; Ansciaux E; Laurent S; Mahieu I; Vander Elst L; Muller RN
    Peptides; 2011 Jun; 32(6):1232-43. PubMed ID: 21575663
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H; Dou J; Li W; Cui W; Mak S; Hu Q; Luo J; Lam CS; Pang Y; Youdim MB; Han Y
    Eur J Pharmacol; 2009 Nov; 623(1-3):14-21. PubMed ID: 19765582
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
    Camps P; El Achab R; Görbig DM; Morral J; Muñoz-Torrero D; Badia A; Eladi Baños J; Vivas NM; Barril X; Orozco M; Luque FJ
    J Med Chem; 1999 Aug; 42(17):3227-42. PubMed ID: 10464010
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.
    Soriano E; Samadi A; Chioua M; de los Ríos C; Marco-Contelles J
    Bioorg Med Chem Lett; 2010 May; 20(9):2950-3. PubMed ID: 20350807
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
    J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
    Camps P; Formosa X; Galdeano C; Gómez T; Muñoz-Torrero D; Ramírez L; Viayna E; Gómez E; Isambert N; Lavilla R; Badia A; Clos MV; Bartolini M; Mancini F; Andrisano V; Bidon-Chanal A; Huertas O; Dafni T; Luque FJ
    Chem Biol Interact; 2010 Sep; 187(1-3):411-5. PubMed ID: 20167211
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning.
    Grisoni F; Merk D; Friedrich L; Schneider G
    ChemMedChem; 2019 Jun; 14(12):1129-1134. PubMed ID: 30973672
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
    Melchiorre C; Andrisano V; Bolognesi ML; Budriesi R; Cavalli A; Cavrini V; Rosini M; Tumiatti V; Recanatini M
    J Med Chem; 1998 Oct; 41(22):4186-9. PubMed ID: 9784091
    [No Abstract]   [Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.