280 related articles for article (PubMed ID: 21994660)
1. HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.
Beilhartz GL; Götte M
Viruses; 2010 Apr; 2(4):900-926. PubMed ID: 21994660
[TBL] [Abstract][Full Text] [Related]
2. Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
Wang L; Sarafianos SG; Wang Z
Acc Chem Res; 2020 Jan; 53(1):218-230. PubMed ID: 31880912
[TBL] [Abstract][Full Text] [Related]
3. Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.
Ilina T; Labarge K; Sarafianos SG; Ishima R; Parniak MA
Biology (Basel); 2012 Oct; 1(3):521-41. PubMed ID: 23599900
[TBL] [Abstract][Full Text] [Related]
4. Recent Advances in Computer-aided Antiviral Drug Design Targeting HIV-1 Integrase and Reverse Transcriptase Associated Ribonuclease H.
Yang F; Yang J; Zhang Z; Tu G; Yao X; Xue W; Zhu F
Curr Med Chem; 2022; 29(10):1664-1676. PubMed ID: 34238145
[TBL] [Abstract][Full Text] [Related]
5. Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.
Boyer PL; Smith SJ; Zhao XZ; Das K; Gruber K; Arnold E; Burke TR; Hughes SH
J Virol; 2018 Jul; 92(13):. PubMed ID: 29643235
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
Vernekar SK; Liu Z; Nagy E; Miller L; Kirby KA; Wilson DJ; Kankanala J; Sarafianos SG; Parniak MA; Wang Z
J Med Chem; 2015 Jan; 58(2):651-64. PubMed ID: 25522204
[TBL] [Abstract][Full Text] [Related]
7. Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs.
Himmel DM; Myshakina NS; Ilina T; Van Ry A; Ho WC; Parniak MA; Arnold E
J Mol Biol; 2014 Jul; 426(14):2617-31. PubMed ID: 24840303
[TBL] [Abstract][Full Text] [Related]
8. Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.
Esposito F; Sanna C; Del Vecchio C; Cannas V; Venditti A; Corona A; Bianco A; Serrilli AM; Guarcini L; Parolin C; Ballero M; Tramontano E
Pathog Dis; 2013 Aug; 68(3):116-24. PubMed ID: 23821410
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
Kankanala J; Kirby KA; Huber AD; Casey MC; Wilson DJ; Sarafianos SG; Wang Z
Eur J Med Chem; 2017 Dec; 141():149-161. PubMed ID: 29031062
[TBL] [Abstract][Full Text] [Related]
10. 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
Wang L; Tang J; Huber AD; Casey MC; Kirby KA; Wilson DJ; Kankanala J; Xie J; Parniak MA; Sarafianos SG; Wang Z
Eur J Med Chem; 2018 Aug; 156():652-665. PubMed ID: 30031976
[TBL] [Abstract][Full Text] [Related]
11. Small-molecule Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function: Challenges and Recent Developments.
Madia VN; Messore A; De Leo A; Tudino V; Pindinello I; Saccoliti F; De Vita D; Scipione L; Costi R; Di Santo R
Curr Med Chem; 2021; 28(30):6146-6178. PubMed ID: 34225606
[TBL] [Abstract][Full Text] [Related]
12. Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
Corona A; Meleddu R; Esposito F; Distinto S; Bianco G; Masaoka T; Maccioni E; Menéndez-Arias L; Alcaro S; Le Grice SF; Tramontano E
PLoS One; 2016; 11(1):e0147225. PubMed ID: 26800261
[TBL] [Abstract][Full Text] [Related]
13. 1,2,4-Triazolo[1,5-
Desantis J; Massari S; Corona A; Astolfi A; Sabatini S; Manfroni G; Palazzotti D; Cecchetti V; Pannecouque C; Tramontano E; Tabarrini O
Molecules; 2020 Mar; 25(5):. PubMed ID: 32151066
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Tang J; Vernekar SKV; Chen YL; Miller L; Huber AD; Myshakina N; Sarafianos SG; Parniak MA; Wang Z
Eur J Med Chem; 2017 Jun; 133():85-96. PubMed ID: 28384548
[TBL] [Abstract][Full Text] [Related]
15. 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
Tang J; Liu F; Nagy E; Miller L; Kirby KA; Wilson DJ; Wu B; Sarafianos SG; Parniak MA; Wang Z
J Med Chem; 2016 Mar; 59(6):2648-59. PubMed ID: 26927866
[TBL] [Abstract][Full Text] [Related]
16. Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones.
Arion D; Sluis-Cremer N; Min KL; Abram ME; Fletcher RS; Parniak MA
J Biol Chem; 2002 Jan; 277(2):1370-4. PubMed ID: 11684697
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors.
Zhang L; Wei F; Borrego D; Zhao F; Río JMD; Frutos-Beltrán E; Zhang J; Xu S; López-Carrobles N; Gao S; Kang D; Pannecouque C; Clercq E; Liu X; Menéndez-Arias L; Zhan P
Eur J Med Chem; 2022 Oct; 240():114563. PubMed ID: 35780636
[TBL] [Abstract][Full Text] [Related]
18. Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
Masaoka T; Chung S; Caboni P; Rausch JW; Wilson JA; Taskent-Sezgin H; Beutler JA; Tocco G; Le Grice SF
J Med Chem; 2013 Jul; 56(13):5436-45. PubMed ID: 23631411
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.
Beilhartz GL; Ngure M; Johns BA; DeAnda F; Gerondelis P; Götte M
J Biol Chem; 2014 Jun; 289(23):16270-7. PubMed ID: 24719329
[TBL] [Abstract][Full Text] [Related]
20. Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors.
Kang D; Urhan Ç; Wei F; Frutos-Beltrán E; Sun L; Álvarez M; Feng D; Tao Y; Pannecouque C; De Clercq E; Menéndez-Arias L; Liu X; Zhan P
Eur J Med Chem; 2021 Dec; 225():113769. PubMed ID: 34403976
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]