96 related articles for article (PubMed ID: 22003817)
1. Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.
Ishikawa T; Seto M; Banno H; Kawakita Y; Oorui M; Taniguchi T; Ohta Y; Tamura T; Nakayama A; Miki H; Kamiguchi H; Tanaka T; Habuka N; Sogabe S; Yano J; Aertgeerts K; Kamiyama K
J Med Chem; 2011 Dec; 54(23):8030-50. PubMed ID: 22003817
[TBL] [Abstract][Full Text] [Related]
2. Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-
Cawrse BM; Robinson NM; Lee NC; Wilson GM; Seley-Radtke KL
Molecules; 2019 Jul; 24(14):. PubMed ID: 31340431
[TBL] [Abstract][Full Text] [Related]
3. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
Aertgeerts K; Skene R; Yano J; Sang BC; Zou H; Snell G; Jennings A; Iwamoto K; Habuka N; Hirokawa A; Ishikawa T; Tanaka T; Miki H; Ohta Y; Sogabe S
J Biol Chem; 2011 May; 286(21):18756-65. PubMed ID: 21454582
[TBL] [Abstract][Full Text] [Related]
4. Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line.
Elrayess R; Abdel Aziz YM; Elgawish MS; Elewa M; Yassen ASA; Elhady SS; Elshihawy HA; Said MM
Pharmaceuticals (Basel); 2020 Dec; 14(1):. PubMed ID: 33374155
[TBL] [Abstract][Full Text] [Related]
5. Computational insights into overcoming resistance mechanisms in targeted therapies for advanced breast cancer: focus on EGFR and HER2 co-inhibition.
Abdulaziz O; Khan FR; Alharthi NS; Alhuthali HM; Hazazi A; Alzahrani HA; Gharib AF; Alsalmi OA; Hawsawi NM; Alhazmi AY
J Biomol Struct Dyn; 2024 Jan; ():1-12. PubMed ID: 38234016
[TBL] [Abstract][Full Text] [Related]
6. Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore.
Mishra S; Sahu A; Kaur A; Kaur M; Kumar J; Wal P
Curr Top Med Chem; 2023 Oct; ():. PubMed ID: 37909440
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.
Kawakita Y; Banno H; Ohashi T; Tamura T; Yusa T; Nakayama A; Miki H; Iwata H; Kamiguchi H; Tanaka T; Habuka N; Sogabe S; Ohta Y; Ishikawa T
J Med Chem; 2012 Apr; 55(8):3975-91. PubMed ID: 22439974
[TBL] [Abstract][Full Text] [Related]
8. A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors.
Hudis C; Swanton C; Janjigian YY; Lee R; Sutherland S; Lehman R; Chandarlapaty S; Hamilton N; Gajria D; Knowles J; Shah J; Shannon K; Tetteh E; Sullivan DM; Moreno C; Yan L; Han HS
Breast Cancer Res; 2013 Nov; 15(6):R110. PubMed ID: 24252402
[TBL] [Abstract][Full Text] [Related]
9. Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model.
Nakayama A; Takagi S; Yusa T; Yaguchi M; Hayashi A; Tamura T; Kawakita Y; Ishikawa T; Ohta Y
J Cancer; 2013; 4(7):557-65. PubMed ID: 23983820
[TBL] [Abstract][Full Text] [Related]
10. Combination neratinib (HKI-272) and paclitaxel therapy in patients with HER2-positive metastatic breast cancer.
Chow LW; Xu B; Gupta S; Freyman A; Zhao Y; Abbas R; Vo Van ML; Bondarenko I
Br J Cancer; 2013 May; 108(10):1985-93. PubMed ID: 23632474
[TBL] [Abstract][Full Text] [Related]
11. Phase I first-in-human study of TAK-285, a novel investigational dual HER2/EGFR inhibitor, in cancer patients.
Doi T; Takiuchi H; Ohtsu A; Fuse N; Goto M; Yoshida M; Dote N; Kuze Y; Jinno F; Fujimoto M; Takubo T; Nakayama N; Tsutsumi R
Br J Cancer; 2012 Feb; 106(4):666-72. PubMed ID: 22240796
[TBL] [Abstract][Full Text] [Related]
12. Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach.
Alsaiari AA; Gharib AF; Bakhuraysah MM; Alrehaili AA; Algethami SM; Alsaif HA; Al Harthi N; Hakami MA
Med Oncol; 2024 Apr; 41(5):117. PubMed ID: 38630325
[TBL] [Abstract][Full Text] [Related]
13. Structure-Based In Silico Approaches Reveal IRESSA as a Multitargeted Breast Cancer Regulatory, Signalling, and Receptor Protein Inhibitor.
Almasoudi HH; Mashraqi MM; Alshamrani SA; Alharthi AA; Alsalmi O; Nahari MH; Al-Mansour FSH; Alhazmi AYM
Pharmaceuticals (Basel); 2024 Feb; 17(2):. PubMed ID: 38399423
[TBL] [Abstract][Full Text] [Related]
14. High-throughput computational screening and
Shahrani MA; Gahtani R; Abohassan M; Alshahrani M; Alraey Y; Dera A; Asiri MR; Rajagopalan P
Oncol Res; 2023; 32(2):251-259. PubMed ID: 38186572
[TBL] [Abstract][Full Text] [Related]
15. New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study.
Fakhry MM; Mattar AA; Alsulaimany M; Al-Olayan EM; Al-Rashood ST; Abdel-Aziz HA
Molecules; 2023 Nov; 28(21):. PubMed ID: 37959874
[No Abstract] [Full Text] [Related]
16. Discovery of New Pyrrolo[2,3-
Alotaibi AA; Alanazi MM; Rahman AFMM
Pharmaceuticals (Basel); 2023 Sep; 16(9):. PubMed ID: 37765132
[TBL] [Abstract][Full Text] [Related]
17. Diosgenin and Monohydroxy Spirostanol from
Shalayel MHF; Al-Mazaideh GM; Alanezi AA; Almuqati AF; Alotaibi M
Pharmaceuticals (Basel); 2023 May; 16(5):. PubMed ID: 37242487
[TBL] [Abstract][Full Text] [Related]
18. Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.
Son S; Elkamhawy A; Gul AR; Al-Karmalawy AA; Alnajjar R; Abdeen A; Ibrahim SF; Alshammari SO; Alshammari QA; Choi WJ; Park TJ; Lee K
J Enzyme Inhib Med Chem; 2023 Dec; 38(1):2202358. PubMed ID: 37096560
[TBL] [Abstract][Full Text] [Related]
19. Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives.
Elkamhawy A; Son S; Lee HY; El-Maghrabey MH; Hamd MAE; Alshammari SO; Abdelhameed AA; Alshammari QA; Abdeen A; Ibrahim SF; Mahdi WA; Alshehri S; Alnajjar R; Choi WJ; Al-Karmalawy AA; Lee K
Pharmaceuticals (Basel); 2022 Dec; 16(1):. PubMed ID: 36678540
[TBL] [Abstract][Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]
