BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 22008547)

  • 1. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.
    Cline GW; Pongratz RL; Zhao X; Papas KK
    Biochem Biophys Res Commun; 2011 Nov; 415(1):30-5. PubMed ID: 22008547
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.
    Cline GW; Lepine RL; Papas KK; Kibbey RG; Shulman GI
    J Biol Chem; 2004 Oct; 279(43):44370-5. PubMed ID: 15304488
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
    Pongratz RL; Kibbey RG; Kirkpatrick CL; Zhao X; Pontoglio M; Yaniv M; Wollheim CB; Shulman GI; Cline GW
    J Biol Chem; 2009 Jun; 284(25):16808-16821. PubMed ID: 19376774
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
    Jesinkey SR; Madiraju AK; Alves TC; Yarborough OH; Cardone RL; Zhao X; Parsaei Y; Nasiri AR; Butrico G; Liu X; Molina AJ; Rountree AM; Neal AS; Wolf DM; Sterpka J; Philbrick WM; Sweet IR; Shirihai OH; Kibbey RG
    Cell Rep; 2019 Jul; 28(3):759-772.e10. PubMed ID: 31315053
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Insights into the role of anaplerosis in insulin secretion: A 13C NMR study.
    Simpson NE; Khokhlova N; Oca-Cossio JA; Constantinidis I
    Diabetologia; 2006 Jun; 49(6):1338-48. PubMed ID: 16575559
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.
    Stark R; Pasquel F; Turcu A; Pongratz RL; Roden M; Cline GW; Shulman GI; Kibbey RG
    J Biol Chem; 2009 Sep; 284(39):26578-90. PubMed ID: 19635791
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells.
    De Marchi U; Hermant A; Thevenet J; Ratinaud Y; Santo-Domingo J; Barron D; Wiederkehr A
    J Cell Sci; 2017 Jun; 130(11):1929-1939. PubMed ID: 28404787
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.
    Heart E; Cline GW; Collis LP; Pongratz RL; Gray JP; Smith PJ
    Am J Physiol Endocrinol Metab; 2009 Jun; 296(6):E1354-62. PubMed ID: 19293334
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.
    Mugabo Y; Zhao S; Lamontagne J; Al-Mass A; Peyot ML; Corkey BE; Joly E; Madiraju SRM; Prentki M
    J Biol Chem; 2017 May; 292(18):7407-7422. PubMed ID: 28280244
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.
    Fransson U; Rosengren AH; Schuit FC; Renström E; Mulder H
    Diabetologia; 2006 Jul; 49(7):1578-86. PubMed ID: 16752176
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.
    Zhang GF; Jensen MV; Gray SM; El K; Wang Y; Lu D; Becker TC; Campbell JE; Newgard CB
    Cell Metab; 2021 Apr; 33(4):804-817.e5. PubMed ID: 33321098
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.
    Pongratz RL; Kibbey RG; Cline GW
    Methods Enzymol; 2009; 457():425-50. PubMed ID: 19426882
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production.
    Cornell D; Miwa S; Georgiou M; Anderson SJ; Honkanen-Scott M; Shaw JAM; Arden C
    Cells; 2022 Jul; 11(15):. PubMed ID: 35954174
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles.
    Cline GW
    Diabetes Metab J; 2011 Oct; 35(5):458-65. PubMed ID: 22111036
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
    Krus U; Kotova O; Spégel P; Hallgard E; Sharoyko VV; Vedin A; Moritz T; Sugden MC; Koeck T; Mulder H
    Biochem J; 2010 Jul; 429(1):205-13. PubMed ID: 20415663
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.
    Brennan L; Shine A; Hewage C; Malthouse JP; Brindle KM; McClenaghan N; Flatt PR; Newsholme P
    Diabetes; 2002 Jun; 51(6):1714-21. PubMed ID: 12031957
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metabolome response to glucose in the β-cell line INS-1 832/13.
    Lorenz MA; El Azzouny MA; Kennedy RT; Burant CF
    J Biol Chem; 2013 Apr; 288(15):10923-35. PubMed ID: 23426361
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.
    Spégel P; Malmgren S; Sharoyko VV; Newsholme P; Koeck T; Mulder H
    Biochem J; 2011 Apr; 435(1):277-84. PubMed ID: 21208194
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.
    MacDonald MJ; Fahien LA; Brown LJ; Hasan NM; Buss JD; Kendrick MA
    Am J Physiol Endocrinol Metab; 2005 Jan; 288(1):E1-15. PubMed ID: 15585595
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mitochondrial GTP regulates glucose-stimulated insulin secretion.
    Kibbey RG; Pongratz RL; Romanelli AJ; Wollheim CB; Cline GW; Shulman GI
    Cell Metab; 2007 Apr; 5(4):253-64. PubMed ID: 17403370
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.