BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

443 related articles for article (PubMed ID: 22012619)

  • 1. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
    Blazek D; Kohoutek J; Bartholomeeusen K; Johansen E; Hulinkova P; Luo Z; Cimermancic P; Ule J; Peterlin BM
    Genes Dev; 2011 Oct; 25(20):2158-72. PubMed ID: 22012619
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.
    Ekumi KM; Paculova H; Lenasi T; Pospichalova V; Bösken CA; Rybarikova J; Bryja V; Geyer M; Blazek D; Barboric M
    Nucleic Acids Res; 2015 Mar; 43(5):2575-89. PubMed ID: 25712099
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.
    Liang K; Gao X; Gilmore JM; Florens L; Washburn MP; Smith E; Shilatifard A
    Mol Cell Biol; 2015 Mar; 35(6):928-38. PubMed ID: 25561469
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cdk12 is essential for embryonic development and the maintenance of genomic stability.
    Juan HC; Lin Y; Chen HR; Fann MJ
    Cell Death Differ; 2016 Jun; 23(6):1038-48. PubMed ID: 26658019
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
    Cheng SW; Kuzyk MA; Moradian A; Ichu TA; Chang VC; Tien JF; Vollett SE; Griffith M; Marra MA; Morin GB
    Mol Cell Biol; 2012 Nov; 32(22):4691-704. PubMed ID: 22988298
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural and Functional Analysis of the Cdk13/Cyclin K Complex.
    Greifenberg AK; Hönig D; Pilarova K; Düster R; Bartholomeeusen K; Bösken CA; Anand K; Blazek D; Geyer M
    Cell Rep; 2016 Jan; 14(2):320-31. PubMed ID: 26748711
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The structure and substrate specificity of human Cdk12/Cyclin K.
    Bösken CA; Farnung L; Hintermair C; Merzel Schachter M; Vogel-Bachmayr K; Blazek D; Anand K; Fisher RP; Eick D; Geyer M
    Nat Commun; 2014 Mar; 5():3505. PubMed ID: 24662513
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
    Bartkowiak B; Liu P; Phatnani HP; Fuda NJ; Cooper JJ; Price DH; Adelman K; Lis JT; Greenleaf AL
    Genes Dev; 2010 Oct; 24(20):2303-16. PubMed ID: 20952539
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
    Dixon-Clarke SE; Elkins JM; Cheng SW; Morin GB; Bullock AN
    Sci Rep; 2015 Nov; 5():17122. PubMed ID: 26597175
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor.
    Niu T; Li K; Jiang L; Zhou Z; Hong J; Chen X; Dong X; He Q; Cao J; Yang B; Zhu CL
    Eur J Med Chem; 2022 Jan; 228():114012. PubMed ID: 34864331
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.
    Greenleaf AL
    Transcription; 2019 Apr; 10(2):91-110. PubMed ID: 30319007
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
    Zhang T; Kwiatkowski N; Olson CM; Dixon-Clarke SE; Abraham BJ; Greifenberg AK; Ficarro SB; Elkins JM; Liang Y; Hannett NM; Manz T; Hao M; Bartkowiak B; Greenleaf AL; Marto JA; Geyer M; Bullock AN; Young RA; Gray NS
    Nat Chem Biol; 2016 Oct; 12(10):876-84. PubMed ID: 27571479
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
    Choi SH; Martinez TF; Kim S; Donaldson C; Shokhirev MN; Saghatelian A; Jones KA
    Genes Dev; 2019 Apr; 33(7-8):418-435. PubMed ID: 30819820
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation.
    Bai Y; Liu Z; Li Y; Zhao H; Lai C; Zhao S; Chen K; Luo C; Yang X; Wang F
    J Am Chem Soc; 2023 May; 145(21):11477-11481. PubMed ID: 37207290
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
    Bartkowiak B; Greenleaf AL
    J Biol Chem; 2015 Jan; 290(3):1786-95. PubMed ID: 25429106
    [TBL] [Abstract][Full Text] [Related]  

  • 16. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.
    Lin X; Taube R; Fujinaga K; Peterlin BM
    J Biol Chem; 2002 May; 277(19):16873-8. PubMed ID: 11884399
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
    Khan SZ; Mitra D
    J Biol Chem; 2011 Jul; 286(26):22943-54. PubMed ID: 21555514
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
    Chen HR; Lin GT; Huang CK; Fann MJ
    Exp Neurol; 2014 Nov; 261():10-21. PubMed ID: 24999027
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylation.
    Choi SH; Kim S; Jones KA
    Exp Mol Med; 2020 May; 52(5):762-771. PubMed ID: 32451425
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.
    Chen HH; Wong YH; Geneviere AM; Fann MJ
    Biochem Biophys Res Commun; 2007 Mar; 354(3):735-40. PubMed ID: 17261272
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.