These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate. Yano T; Kuramitsu S; Tanase S; Morino Y; Kagamiyama H Biochemistry; 1992 Jun; 31(25):5878-87. PubMed ID: 1610831 [TBL] [Abstract][Full Text] [Related]
4. The role of His143 in the catalytic mechanism of Escherichia coli aspartate aminotransferase. Yano T; Kuramitsu S; Tanase S; Morino Y; Hiromi K; Kagamiyama H J Biol Chem; 1991 Apr; 266(10):6079-85. PubMed ID: 2007566 [TBL] [Abstract][Full Text] [Related]
5. The reaction catalyzed by Escherichia coli aspartate aminotransferase has multiple partially rate-determining steps, while that catalyzed by the Y225F mutant is dominated by ketimine hydrolysis. Goldberg JM; Kirsch JF Biochemistry; 1996 Apr; 35(16):5280-91. PubMed ID: 8611515 [TBL] [Abstract][Full Text] [Related]
6. Site-directed mutagenesis of Escherichia coli aspartate aminotransferase: role of Tyr70 in the catalytic processes. Inoue K; Kuramitsu S; Okamoto A; Hirotsu K; Higuchi T; Kagamiyama H Biochemistry; 1991 Aug; 30(31):7796-801. PubMed ID: 1868057 [TBL] [Abstract][Full Text] [Related]
7. Tyr225 in aspartate aminotransferase: contribution of the hydrogen bond between Tyr225 and coenzyme to the catalytic reaction. Inoue K; Kuramitsu S; Okamoto A; Hirotsu K; Higuchi T; Morino Y; Kagamiyama H J Biochem; 1991 Apr; 109(4):570-6. PubMed ID: 1869510 [TBL] [Abstract][Full Text] [Related]
8. Substitution of a lysyl residue for arginine 386 of Escherichia coli aspartate aminotransferase. Inoue Y; Kuramitsu S; Inoue K; Kagamiyama H; Hiromi K; Tanase S; Morino Y J Biol Chem; 1989 Jun; 264(16):9673-81. PubMed ID: 2498335 [TBL] [Abstract][Full Text] [Related]
9. Reaction of aspartate aminotransferase with L-erythro-3-hydroxyaspartate: involvement of Tyr70 in stabilization of the catalytic intermediates. Hayashi H; Kagamiyama H Biochemistry; 1995 Jul; 34(29):9413-23. PubMed ID: 7626611 [TBL] [Abstract][Full Text] [Related]
10. Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity. Vacca RA; Christen P; Malashkevich VN; Jansonius JN; Sandmeier E Eur J Biochem; 1995 Jan; 227(1-2):481-7. PubMed ID: 7851426 [TBL] [Abstract][Full Text] [Related]
11. Characterization of the apparent negative co-operativity induced in Escherichia coli aspartate aminotransferase by the replacement of Asp222 with alanine. Evidence for an extremely slow conformational change. Onuffer JJ; Kirsch JF Protein Eng; 1994 Mar; 7(3):413-24. PubMed ID: 8177890 [TBL] [Abstract][Full Text] [Related]
12. Aspartate aminotransferase of E. coli: effects of site-directed mutagenesis on substrate recognition. Kagamiyama H J Nutr Sci Vitaminol (Tokyo); 1992; Spec No():216-9. PubMed ID: 1297744 [TBL] [Abstract][Full Text] [Related]
13. Probing the role of tightly bound phosphoenolpyruvate in Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time range. Li Z; Sau AK; Furdui CM; Anderson KS Anal Biochem; 2005 Aug; 343(1):35-47. PubMed ID: 15979047 [TBL] [Abstract][Full Text] [Related]
14. Thermodynamics and molecular simulation analysis of hydrophobic substrate recognition by aminotransferases. Kawaguchi Si; Kuramitsu S J Biol Chem; 1998 Jul; 273(29):18353-64. PubMed ID: 9660802 [TBL] [Abstract][Full Text] [Related]
15. Mechanistic aspects of the transamination reactions catalyzed by D-amino acid transaminase from Haliscomenobacter hydrossis. Bakunova AK; Kostyukov AA; Kuzmin VA; Popov VO; Bezsudnova EY Biochim Biophys Acta Proteins Proteom; 2023 Feb; 1871(2):140886. PubMed ID: 36496204 [TBL] [Abstract][Full Text] [Related]
16. A simple method for determination of stereospecificity of aminotransferases for C-4' hydrogen transfer of the coenzyme. Nishimura K; Ito J; Yoshimura T; Esaki N; Soda K Bioorg Med Chem; 1994 Jul; 2(7):605-7. PubMed ID: 7858965 [TBL] [Abstract][Full Text] [Related]
17. The tyrosine-225 to phenylalanine mutation of Escherichia coli aspartate aminotransferase results in an alkaline transition in the spectrophotometric and kinetic pKa values and reduced values of both kcat and Km. Goldberg JM; Swanson RV; Goodman HS; Kirsch JF Biochemistry; 1991 Jan; 30(1):305-12. PubMed ID: 1988027 [TBL] [Abstract][Full Text] [Related]
18. Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. Malashkevich VN; Jäger J; Ziak M; Sauder U; Gehring H; Christen P; Jansonius JN Biochemistry; 1995 Jan; 34(2):405-14. PubMed ID: 7819232 [TBL] [Abstract][Full Text] [Related]
19. Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase. Vacca RA; Giannattasio S; Graber R; Sandmeier E; Marra E; Christen P J Biol Chem; 1997 Aug; 272(35):21932-7. PubMed ID: 9268327 [TBL] [Abstract][Full Text] [Related]
20. Kinetics and equilibria for the reactions of coenzymes with wild type and the Y70F mutant of Escherichia coli aspartate aminotransferase. Toney MD; Kirsch JF Biochemistry; 1991 Jul; 30(30):7461-6. PubMed ID: 1677270 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]