These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
152 related articles for article (PubMed ID: 22014550)
1. Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Moffett K; Konteatis Z; Nguyen D; Shetty R; Ludington J; Fujimoto T; Lee KJ; Chai X; Namboodiri H; Karpusas M; Dorsey B; Guarnieri F; Bukhtiyarova M; Springman E; Michelotti E Bioorg Med Chem Lett; 2011 Dec; 21(23):7155-65. PubMed ID: 22014550 [TBL] [Abstract][Full Text] [Related]
2. Discovery and optimization of p38 inhibitors via computer-assisted drug design. Goldberg DR; Hao MH; Qian KC; Swinamer AD; Gao DA; Xiong Z; Sarko C; Berry A; Lord J; Magolda RL; Fadra T; Kroe RR; Kukulka A; Madwed JB; Martin L; Pargellis C; Skow D; Song JJ; Tan Z; Torcellini CA; Zimmitti CS; Yee NK; Moss N J Med Chem; 2007 Aug; 50(17):4016-26. PubMed ID: 17658737 [TBL] [Abstract][Full Text] [Related]
3. Virtual screening filters for the design of type II p38 MAP kinase inhibitors: a fragment based library generation approach. Badrinarayan P; Sastry GN J Mol Graph Model; 2012 Apr; 34():89-100. PubMed ID: 22306417 [TBL] [Abstract][Full Text] [Related]
4. 3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead. Soth M; Abbot S; Abubakari A; Arora N; Arzeno H; Billedeau R; Dewdney N; Durkin K; Frauchiger S; Ghate M; Goldstein DM; Hill RJ; Kuglstatter A; Li F; Loe B; McCaleb K; McIntosh J; Papp E; Park J; Stahl M; Sung ML; Suttman R; Swinney DC; Weller P; Wong B; Zecic H; Gabriel T Bioorg Med Chem Lett; 2011 Jun; 21(11):3452-6. PubMed ID: 21515047 [TBL] [Abstract][Full Text] [Related]
5. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery. Erlanson DA; Arndt JW; Cancilla MT; Cao K; Elling RA; English N; Friedman J; Hansen SK; Hession C; Joseph I; Kumaravel G; Lee WC; Lind KE; McDowell RS; Miatkowski K; Nguyen C; Nguyen TB; Park S; Pathan N; Penny DM; Romanowski MJ; Scott D; Silvian L; Simmons RL; Tangonan BT; Yang W; Sun L Bioorg Med Chem Lett; 2011 May; 21(10):3078-83. PubMed ID: 21459573 [TBL] [Abstract][Full Text] [Related]
6. Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. Gill AL; Frederickson M; Cleasby A; Woodhead SJ; Carr MG; Woodhead AJ; Walker MT; Congreve MS; Devine LA; Tisi D; O'Reilly M; Seavers LC; Davis DJ; Curry J; Anthony R; Padova A; Murray CW; Carr RA; Jhoti H J Med Chem; 2005 Jan; 48(2):414-26. PubMed ID: 15658855 [TBL] [Abstract][Full Text] [Related]
8. Computational sampling of a cryptic drug binding site in a protein receptor: explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase. Frembgen-Kesner T; Elcock AH J Mol Biol; 2006 May; 359(1):202-14. PubMed ID: 16616932 [TBL] [Abstract][Full Text] [Related]
9. Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors. Lin TH; Metzger A; Diller DJ; Desai M; Henderson I; Ahmed G; Kimble EF; Quadros E; Webb ML J Pharmacol Exp Ther; 2006 Aug; 318(2):495-502. PubMed ID: 16702443 [TBL] [Abstract][Full Text] [Related]
10. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814 [TBL] [Abstract][Full Text] [Related]
11. Structure-based design of thienobenzoxepin inhibitors of PI3-kinase. Staben ST; Siu M; Goldsmith R; Olivero AG; Do S; Burdick DJ; Heffron TP; Dotson J; Sutherlin DP; Zhu BY; Tsui V; Le H; Lee L; Lesnick J; Lewis C; Murray JM; Nonomiya J; Pang J; Prior WW; Salphati L; Rouge L; Sampath D; Sideris S; Wiesmann C; Wu P Bioorg Med Chem Lett; 2011 Jul; 21(13):4054-8. PubMed ID: 21636270 [TBL] [Abstract][Full Text] [Related]
12. Sequence, structure, and active site analyses of p38 MAP kinase: exploiting DFG-out conformation as a strategy to design new type II leads. Badrinarayan P; Sastry GN J Chem Inf Model; 2011 Jan; 51(1):115-29. PubMed ID: 21141877 [TBL] [Abstract][Full Text] [Related]
13. Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase. Cogan DA; Aungst R; Breinlinger EC; Fadra T; Goldberg DR; Hao MH; Kroe R; Moss N; Pargellis C; Qian KC; Swinamer AD Bioorg Med Chem Lett; 2008 Jun; 18(11):3251-5. PubMed ID: 18462940 [TBL] [Abstract][Full Text] [Related]
14. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Xiang Y; Hirth B; Asmussen G; Biemann HP; Bishop KA; Good A; Fitzgerald M; Gladysheva T; Jain A; Jancsics K; Liu J; Metz M; Papoulis A; Skerlj R; Stepp JD; Wei RR Bioorg Med Chem Lett; 2011 May; 21(10):3050-6. PubMed ID: 21507633 [TBL] [Abstract][Full Text] [Related]
15. Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase. Hammach A; Barbosa A; Gaenzler FC; Fadra T; Goldberg D; Hao MH; Kroe RR; Liu P; Qian KC; Ralph M; Sarko C; Soleymanzadeh F; Moss N Bioorg Med Chem Lett; 2006 Dec; 16(24):6316-20. PubMed ID: 17010605 [TBL] [Abstract][Full Text] [Related]
16. Displacement assay for the detection of stabilizers of inactive kinase conformations. Klüter S; Grütter C; Naqvi T; Rabiller M; Simard JR; Pawar V; Getlik M; Rauh D J Med Chem; 2010 Jan; 53(1):357-67. PubMed ID: 19928858 [TBL] [Abstract][Full Text] [Related]