BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 22015772)

  • 21. JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms.
    Oh ST; Gotlib J
    Expert Rev Hematol; 2010 Jun; 3(3):323-37. PubMed ID: 21082983
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.
    Liu PC; Caulder E; Li J; Waeltz P; Margulis A; Wynn R; Becker-Pasha M; Li Y; Crowgey E; Hollis G; Haley P; Sparks RB; Combs AP; Rodgers JD; Burn TC; Vaddi K; Fridman JS
    Clin Cancer Res; 2009 Nov; 15(22):6891-900. PubMed ID: 19887489
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells.
    Amaru Calzada A; Todoerti K; Donadoni L; Pellicioli A; Tuana G; Gatta R; Neri A; Finazzi G; Mantovani R; Rambaldi A; Introna M; Lombardi L; Golay J;
    Exp Hematol; 2012 Aug; 40(8):634-45.e10. PubMed ID: 22579713
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Comparison of two homogeneous cell-based kinase assays for JAK2 V617F: SureFire pSTAT5 and GeneBLAzer fluorescence resonance energy transfer assays.
    Qian J; Mason JL; Holskin BP; Murray KA; Meyer SL; Ator MA; Angeles TS
    Assay Drug Dev Technol; 2012 Apr; 10(2):212-7. PubMed ID: 22132729
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Janus kinase inhibitors: an update on the progress and promise of targeted therapy in the myeloproliferative neoplasms.
    Stein BL; Crispino JD; Moliterno AR
    Curr Opin Oncol; 2011 Nov; 23(6):609-16. PubMed ID: 21993415
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Janus kinase 2 inhibitors in myeloproliferative disorders.
    Lucia E; Recchia AG; Gentile M; Bossio S; Vigna E; Mazzone C; Madeo A; Morabito L; Gigliotti V; De Stefano L; Caruso N; Servillo P; Franzese S; Bisconte MG; Gentile C; Morabito F
    Expert Opin Investig Drugs; 2011 Jan; 20(1):41-59. PubMed ID: 21128825
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders.
    Brasca MG; Gnocchi P; Nesi M; Amboldi N; Avanzi N; Bertrand J; Bindi S; Canevari G; Casero D; Ciomei M; Colombo N; Cribioli S; Fachin G; Felder ER; Galvani A; Isacchi A; Motto I; Panzeri A; Donati D
    Bioorg Med Chem; 2015 May; 23(10):2387-407. PubMed ID: 25882525
    [TBL] [Abstract][Full Text] [Related]  

  • 28. C-H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543.
    Fox RJ; Cuniere NL; Bakrania L; Wei C; Strotman NA; Hay M; Fanfair D; Regens C; Beutner GL; Lawler M; Lobben P; Soumeillant MC; Cohen B; Zhu K; Skliar D; Rosner T; Markwalter CE; Hsiao Y; Tran K; Eastgate MD
    J Org Chem; 2019 Apr; 84(8):4661-4669. PubMed ID: 30388009
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Imatinib effect on growth and signal transduction in polycythemia vera.
    Gaikwad A; Verstovsek S; Yoon D; Chang KT; Manshouri T; Nussenzveig R; Cortes J; Vainchenker W; Prchal JT
    Exp Hematol; 2007 Jun; 35(6):931-8. PubMed ID: 17533047
    [TBL] [Abstract][Full Text] [Related]  

  • 30. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations.
    Pardanani A; Hood J; Lasho T; Levine RL; Martin MB; Noronha G; Finke C; Mak CC; Mesa R; Zhu H; Soll R; Gilliland DG; Tefferi A
    Leukemia; 2007 Aug; 21(8):1658-68. PubMed ID: 17541402
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.
    Su Q; Ioannidis S; Chuaqui C; Almeida L; Alimzhanov M; Bebernitz G; Bell K; Block M; Howard T; Huang S; Huszar D; Read JA; Rivard Costa C; Shi J; Su M; Ye M; Zinda M
    J Med Chem; 2014 Jan; 57(1):144-58. PubMed ID: 24359159
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance.
    Huang SM; Wang A; Greco R; Li Z; Barberis C; Tabart M; Patel V; Schio L; Hurley R; Chen B; Cheng H; Lengauer C; Pollard J; Watters J; Garcia-Echeverria C; Wiederschain D; Adrian F; Zhang J
    Oncotarget; 2014 May; 5(10):3362-74. PubMed ID: 24830942
    [TBL] [Abstract][Full Text] [Related]  

  • 33. 2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation.
    Weinberg LR; Albom MS; Angeles TS; Breslin HJ; Gingrich DE; Huang Z; Lisko JG; Mason JL; Milkiewicz KL; Thieu TV; Underiner TL; Wells GJ; Wells-Knecht KJ; Dorsey BD
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7325-30. PubMed ID: 22041060
    [TBL] [Abstract][Full Text] [Related]  

  • 34. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
    Duan Z; Bradner J; Greenberg E; Mazitschek R; Foster R; Mahoney J; Seiden MV
    Mol Pharmacol; 2007 Nov; 72(5):1137-45. PubMed ID: 17675586
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.
    Tong H; Ren Y; Zhang F; Jin J
    Eur J Haematol; 2008 Oct; 81(4):259-66. PubMed ID: 18616510
    [TBL] [Abstract][Full Text] [Related]  

  • 36. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
    Ledeboer MW; Pierce AC; Duffy JP; Gao H; Messersmith D; Salituro FG; Nanthakumar S; Come J; Zuccola HJ; Swenson L; Shlyakter D; Mahajan S; Hoock T; Fan B; Tsai WJ; Kolaczkowski E; Carrier S; Hogan JK; Zessis R; Pazhanisamy S; Bennani YL
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6529-33. PubMed ID: 19857967
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.
    Williams NK; Bamert RS; Patel O; Wang C; Walden PM; Wilks AF; Fantino E; Rossjohn J; Lucet IS
    J Mol Biol; 2009 Mar; 387(1):219-32. PubMed ID: 19361440
    [TBL] [Abstract][Full Text] [Related]  

  • 38. A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.
    Dugan BJ; Gingrich DE; Mesaros EF; Milkiewicz KL; Curry MA; Zulli AL; Dobrzanski P; Serdikoff C; Jan M; Angeles TS; Albom MS; Mason JL; Aimone LD; Meyer SL; Huang Z; Wells-Knecht KJ; Ator MA; Ruggeri BA; Dorsey BD
    J Med Chem; 2012 Jun; 55(11):5243-54. PubMed ID: 22594690
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A novel indole-3-propanamide exerts its immunosuppressive activity by inhibiting JAK3 in T cells.
    Carbonnelle D; Duflos M; Marchand P; Chauvet C; Petit JY; Lang F
    J Pharmacol Exp Ther; 2009 Nov; 331(2):710-6. PubMed ID: 19710367
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.
    Yang SH; Khadka DB; Cho SH; Ju HK; Lee KY; Han HJ; Lee KT; Cho WJ
    Bioorg Med Chem; 2011 Jan; 19(2):968-77. PubMed ID: 21185195
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.