BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

236 related articles for article (PubMed ID: 22023140)

  • 21. DprE1 and Ddn as promising therapeutic targets in the development of novel anti-tuberculosis nitroaromatic drugs.
    Paoli-Lombardo R; Primas N; Vanelle P
    Eur J Med Chem; 2024 Aug; 274():116559. PubMed ID: 38850856
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.
    Hurdle JG; Lee RB; Budha NR; Carson EI; Qi J; Scherman MS; Cho SH; McNeil MR; Lenaerts AJ; Franzblau SG; Meibohm B; Lee RE
    J Antimicrob Chemother; 2008 Nov; 62(5):1037-45. PubMed ID: 18693235
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F
    Jian Y; Forbes HE; Hulpia F; Risseeuw MDP; Caljon G; Munier-Lehmann H; Boshoff HIM; Van Calenbergh S
    J Med Chem; 2021 Jan; 64(1):440-457. PubMed ID: 33347317
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.
    Manjunatha UH; Boshoff H; Dowd CS; Zhang L; Albert TJ; Norton JE; Daniels L; Dick T; Pang SS; Barry CE
    Proc Natl Acad Sci U S A; 2006 Jan; 103(2):431-6. PubMed ID: 16387854
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Microbiology. An antibiotic mimics immunity.
    Nathan C
    Science; 2008 Nov; 322(5906):1337-8. PubMed ID: 19039126
    [No Abstract]   [Full Text] [Related]  

  • 26. 3D-QSAR and cell wall permeability of antitubercular nitroimidazoles against Mycobacterium tuberculosis.
    Lee SH; Choi M; Kim P; Myung PK
    Molecules; 2013 Nov; 18(11):13870-85. PubMed ID: 24217328
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from
    Zhang F; Li S; Wen S; Zhang T; Shang Y; Huo F; Xue Y; Li L; Pang Y
    Infect Drug Resist; 2020; 13():815-822. PubMed ID: 32210596
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
    Ang CW; Lee BM; Jackson CJ; Wang Y; Franzblau SG; Francisco AF; Kelly JM; Bernhardt PV; Tan L; West NP; Sykes ML; Hinton AO; Bolisetti R; Avery VM; Cooper MA; Blaskovich MAT
    J Med Chem; 2022 Oct; 65(19):13125-13142. PubMed ID: 36111399
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.
    Feuerriegel S; Köser CU; Baù D; Rüsch-Gerdes S; Summers DK; Archer JA; Marti-Renom MA; Niemann S
    Antimicrob Agents Chemother; 2011 Dec; 55(12):5718-22. PubMed ID: 21930879
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
    Bashiri G; Squire CJ; Moreland NJ; Baker EN
    J Biol Chem; 2008 Jun; 283(25):17531-41. PubMed ID: 18434308
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The
    Mansjö M; Karlsson Lindsjö O; Grönfors Seeth C; Groenheit R; Werngren J
    Antimicrob Agents Chemother; 2022 Dec; 66(12):e0102622. PubMed ID: 36409105
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Delamanid is not metabolized by Salmonella or human nitroreductases: A possible mechanism for the lack of mutagenicity.
    Hanaki E; Hayashi M; Matsumoto M
    Regul Toxicol Pharmacol; 2017 Mar; 84():1-8. PubMed ID: 27988333
    [TBL] [Abstract][Full Text] [Related]  

  • 33. New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053.
    Chiarelli LR; Salina EG; Mori G; Azhikina T; Riabova O; Lepioshkin A; Grigorov A; Forbak M; Madacki J; Orena BS; Manfredi M; Gosetti F; Buzzi A; Degiacomi G; Sammartino JC; Marengo E; Korduláková J; Riccardi G; Mikušová K; Makarov V; Pasca MR
    ACS Infect Dis; 2020 Feb; 6(2):313-323. PubMed ID: 31729215
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
    Thompson AM; Blaser A; Anderson RF; Shinde SS; Franzblau SG; Ma Z; Denny WA; Palmer BD
    J Med Chem; 2009 Feb; 52(3):637-45. PubMed ID: 19099398
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.
    Thompson AM; Blaser A; Palmer BD; Franzblau SG; Wan B; Wang Y; Ma Z; Denny WA
    Bioorg Med Chem Lett; 2015 Sep; 25(18):3804-9. PubMed ID: 26253632
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis.
    Saliu OY; Crismale C; Schwander SK; Wallis RS
    J Antimicrob Chemother; 2007 Nov; 60(5):994-8. PubMed ID: 17761500
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824.
    Cellitti SE; Shaffer J; Jones DH; Mukherjee T; Gurumurthy M; Bursulaya B; Boshoff HI; Choi I; Nayyar A; Lee YS; Cherian J; Niyomrattanakit P; Dick T; Manjunatha UH; Barry CE; Spraggon G; Geierstanger BH
    Structure; 2013 Jan; 21(1):191. PubMed ID: 28903033
    [No Abstract]   [Full Text] [Related]  

  • 38. Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system.
    Schena E; Nedialkova L; Borroni E; Battaglia S; Cabibbe AM; Niemann S; Utpatel C; Merker M; Trovato A; Hofmann-Thiel S; Hoffmann H; Cirillo DM
    J Antimicrob Chemother; 2016 Jun; 71(6):1532-9. PubMed ID: 27076101
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
    Kim P; Kang S; Boshoff HI; Jiricek J; Collins M; Singh R; Manjunatha UH; Niyomrattanakit P; Zhang L; Goodwin M; Dick T; Keller TH; Dowd CS; Barry CE
    J Med Chem; 2009 Mar; 52(5):1329-44. PubMed ID: 19209893
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
    Negri A; Javidnia P; Mu R; Zhang X; Vendome J; Gold B; Roberts J; Barman D; Ioerger T; Sacchettini JC; Jiang X; Burns-Huang K; Warrier T; Ling Y; Warren JD; Oren DA; Beuming T; Wang H; Wu J; Li H; Rhee KY; Nathan CF; Liu G; Somersan-Karakaya S
    ACS Infect Dis; 2018 May; 4(5):771-787. PubMed ID: 29465985
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.