These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 22027695)

  • 1. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.
    Chenna V; Hu C; Pramanik D; Aftab BT; Karikari C; Campbell NR; Hong SM; Zhao M; Rudek MA; Khan SR; Rudin CM; Maitra A
    Mol Cancer Ther; 2012 Jan; 11(1):165-73. PubMed ID: 22027695
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma.
    Xu Y; Chenna V; Hu C; Sun HX; Khan M; Bai H; Yang XR; Zhu QF; Sun YF; Maitra A; Fan J; Anders RA
    Clin Cancer Res; 2012 Mar; 18(5):1291-302. PubMed ID: 21868763
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
    Guo J; Gao J; Li Z; Gong Y; Man X; Jin J; Wu H
    Cancer Lett; 2013 Oct; 339(2):185-94. PubMed ID: 23791879
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.
    Cohen JR; Resnick DZ; Niewiadomski P; Dong H; Liau LM; Waschek JA
    BMC Cancer; 2010 Dec; 10():676. PubMed ID: 21143927
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM
    J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
    Rohner A; Spilker ME; Lam JL; Pascual B; Bartkowski D; Li QJ; Yang AH; Stevens G; Xu M; Wells PA; Planken S; Nair S; Sun S
    Mol Cancer Ther; 2012 Jan; 11(1):57-65. PubMed ID: 22084163
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.
    Werminghaus P; Haase M; Hornsby PJ; Schinner S; Schott M; Malendowicz LK; Lammers BJ; Goretzki PE; Müller-Mattheis V; Markus Giessing ; Willenberg HS
    J Steroid Biochem Mol Biol; 2014 Jan; 139():7-15. PubMed ID: 24063979
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
    Galimberti F; Busch AM; Chinyengetere F; Ma T; Sekula D; Memoli VA; Dragnev KH; Liu F; Johnson KC; Guo Y; Freemantle SJ; Andrew AS; Greninger P; Robbins DJ; Settleman J; Benes C; Dmitrovsky E
    Int J Oncol; 2012 Nov; 41(5):1751-61. PubMed ID: 22923130
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
    Bahra M; Kamphues C; Boas-Knoop S; Lippert S; Esendik U; Schüller U; Hartmann W; Waha A; Neuhaus P; Heppner F; Pietsch T; Koch A
    Pancreas; 2012 Mar; 41(2):222-9. PubMed ID: 22076568
    [TBL] [Abstract][Full Text] [Related]  

  • 10. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.
    Zhuang Z; Wang K; Cheng X; Qu X; Jiang B; Li Z; Luo J; Shao Z; Duan T
    PLoS One; 2013; 8(7):e67431. PubMed ID: 23861764
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
    Onishi H; Morifuji Y; Kai M; Suyama K; Iwasaki H; Katano M
    Cancer Sci; 2012 Jul; 103(7):1272-9. PubMed ID: 22486854
    [TBL] [Abstract][Full Text] [Related]  

  • 12. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
    Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F
    Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
    Götschel F; Berg D; Gruber W; Bender C; Eberl M; Friedel M; Sonntag J; Rüngeler E; Hache H; Wierling C; Nietfeld W; Lehrach H; Frischauf A; Schwartz-Albiez R; Aberger F; Korf U
    PLoS One; 2013; 8(6):e65403. PubMed ID: 23762360
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.
    Decker S; Zirlik K; Djebatchie L; Hartmann D; Ihorst G; Schmitt-Graeff A; Herchenbach D; Jumaa H; Warmuth M; Veelken H; Dierks C
    Blood; 2012 Jan; 119(4):997-1007. PubMed ID: 22130798
    [TBL] [Abstract][Full Text] [Related]  

  • 15. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.
    Busch AM; Galimberti F; Nehls KE; Roengvoraphoj M; Sekula D; Li B; Guo Y; Direnzo J; Fiering SN; Spinella MJ; Robbins DJ; Memoli VA; Freemantle SJ; Dmitrovsky E
    Cancer Biol Ther; 2014 Apr; 15(4):463-72. PubMed ID: 24496080
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.
    Dijkgraaf GJ; Alicke B; Weinmann L; Januario T; West K; Modrusan Z; Burdick D; Goldsmith R; Robarge K; Sutherlin D; Scales SJ; Gould SE; Yauch RL; de Sauvage FJ
    Cancer Res; 2011 Jan; 71(2):435-44. PubMed ID: 21123452
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
    Yauch RL; Dijkgraaf GJ; Alicke B; Januario T; Ahn CP; Holcomb T; Pujara K; Stinson J; Callahan CA; Tang T; Bazan JF; Kan Z; Seshagiri S; Hann CL; Gould SE; Low JA; Rudin CM; de Sauvage FJ
    Science; 2009 Oct; 326(5952):572-4. PubMed ID: 19726788
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.
    Ramaswamy B; Lu Y; Teng KY; Nuovo G; Li X; Shapiro CL; Majumder S
    Cancer Res; 2012 Oct; 72(19):5048-59. PubMed ID: 22875023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
    Hoch L; Faure H; Roudaut H; Schoenfelder A; Mann A; Girard N; Bihannic L; Ayrault O; Petricci E; Taddei M; Rognan D; Ruat M
    FASEB J; 2015 May; 29(5):1817-29. PubMed ID: 25636740
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma.
    Wei SF; He DH; Zhang SB; Lu Y; Ye X; Fan XZ; Wang H; Wang Q; Liu YQ
    Biochem Pharmacol; 2021 Aug; 190():114593. PubMed ID: 33964282
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.