172 related articles for article (PubMed ID: 22030621)
1. Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition.
Höglund A; Strömvall K; Li Y; Forshell LP; Nilsson JA
Cell Cycle; 2011 Oct; 10(20):3598-607. PubMed ID: 22030621
[TBL] [Abstract][Full Text] [Related]
2. MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells.
Wang WJ; Wu SP; Liu JB; Shi YS; Huang X; Zhang QB; Yao KT
Cancer Res; 2013 Feb; 73(3):1219-31. PubMed ID: 23269272
[TBL] [Abstract][Full Text] [Related]
3. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
Morgan MA; Parsels LA; Zhao L; Parsels JD; Davis MA; Hassan MC; Arumugarajah S; Hylander-Gans L; Morosini D; Simeone DM; Canman CE; Normolle DP; Zabludoff SD; Maybaum J; Lawrence TS
Cancer Res; 2010 Jun; 70(12):4972-81. PubMed ID: 20501833
[TBL] [Abstract][Full Text] [Related]
4. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Smith J; Tho LM; Xu N; Gillespie DA
Adv Cancer Res; 2010; 108():73-112. PubMed ID: 21034966
[TBL] [Abstract][Full Text] [Related]
5. Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma.
Derenzini E; Agostinelli C; Imbrogno E; Iacobucci I; Casadei B; Brighenti E; Righi S; Fuligni F; Ghelli Luserna Di Rorà A; Ferrari A; Martinelli G; Pileri S; Zinzani PL
Oncotarget; 2015 Mar; 6(9):6553-69. PubMed ID: 25544753
[TBL] [Abstract][Full Text] [Related]
6. Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine.
Isono M; Hoffmann MJ; Pinkerneil M; Sato A; Michaelis M; Cinatl J; Niegisch G; Schulz WA
J Exp Clin Cancer Res; 2017 Jan; 36(1):1. PubMed ID: 28049532
[TBL] [Abstract][Full Text] [Related]
7. Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
Aris SM; Pommier Y
Cancer Res; 2012 Feb; 72(4):979-89. PubMed ID: 22189968
[TBL] [Abstract][Full Text] [Related]
8. Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells.
Ferrao PT; Bukczynska EP; Johnstone RW; McArthur GA
Oncogene; 2012 Mar; 31(13):1661-72. PubMed ID: 21841818
[TBL] [Abstract][Full Text] [Related]
9. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.
Urist M; Tanaka T; Poyurovsky MV; Prives C
Genes Dev; 2004 Dec; 18(24):3041-54. PubMed ID: 15601819
[TBL] [Abstract][Full Text] [Related]
10. Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Galindo-Campos MA; Lutfi N; Bonnin S; Martínez C; Velasco-Hernandez T; García-Hernández V; Martín-Caballero J; Ampurdanés C; Gimeno R; Colomo L; Roué G; Guilbaud G; Dantzer F; Navarro P; Murga M; Fernández-Capetillo O; Bigas A; Menéndez P; Sale JE; Yélamos J
Blood; 2022 Jan; 139(2):228-239. PubMed ID: 34359075
[TBL] [Abstract][Full Text] [Related]
11. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Cannell IG; Kong YW; Johnston SJ; Chen ML; Collins HM; Dobbyn HC; Elia A; Kress TR; Dickens M; Clemens MJ; Heery DM; Gaestel M; Eilers M; Willis AE; Bushell M
Proc Natl Acad Sci U S A; 2010 Mar; 107(12):5375-80. PubMed ID: 20212154
[TBL] [Abstract][Full Text] [Related]
12. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.
Carrozza MJ; Stefanick DF; Horton JK; Kedar PS; Wilson SH
DNA Repair (Amst); 2009 Nov; 8(11):1264-72. PubMed ID: 19717351
[TBL] [Abstract][Full Text] [Related]
13. Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K; Geist K; Stuhldreier F; Schumacher L; Blümel L; Remke M; Wesselborg S; Stork B; Klöcker N; Bormann S; Roos WP; Honnen S; Fritz G
Cancer Lett; 2018 Aug; 430():34-46. PubMed ID: 29753759
[TBL] [Abstract][Full Text] [Related]
14. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.
Horton JK; Stefanick DF; Zeng JY; Carrozza MJ; Wilson SH
DNA Repair (Amst); 2011 Feb; 10(2):225-34. PubMed ID: 21130714
[TBL] [Abstract][Full Text] [Related]
15. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
Anderson VE; Walton MI; Eve PD; Boxall KJ; Antoni L; Caldwell JJ; Aherne W; Pearl LH; Oliver AW; Collins I; Garrett MD
Cancer Res; 2011 Jan; 71(2):463-72. PubMed ID: 21239475
[TBL] [Abstract][Full Text] [Related]
16. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
den Hollander J; Rimpi S; Doherty JR; Rudelius M; Buck A; Hoellein A; Kremer M; Graf N; Scheerer M; Hall MA; Goga A; von Bubnoff N; Duyster J; Peschel C; Cleveland JL; Nilsson JA; Keller U
Blood; 2010 Sep; 116(9):1498-505. PubMed ID: 20519624
[TBL] [Abstract][Full Text] [Related]
17. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
Soares DG; Battistella A; Rocca CJ; Matuo R; Henriques JA; Larsen AK; Escargueil AE
Biochem J; 2011 Jul; 437(1):63-73. PubMed ID: 21470188
[TBL] [Abstract][Full Text] [Related]
18. Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas.
Shortt J; Martin BP; Newbold A; Hannan KM; Devlin JR; Baker AJ; Ralli R; Cullinane C; Schmitt CA; Reimann M; Hall MN; Wall M; Hannan RD; Pearson RB; McArthur GA; Johnstone RW
Blood; 2013 Apr; 121(15):2964-74. PubMed ID: 23403624
[TBL] [Abstract][Full Text] [Related]
19. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
Pabla N; Huang S; Mi QS; Daniel R; Dong Z
J Biol Chem; 2008 Mar; 283(10):6572-83. PubMed ID: 18162465
[TBL] [Abstract][Full Text] [Related]
20. Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
Maclean KH; Kastan MB; Cleveland JL
Mol Cancer Res; 2007 Jul; 5(7):705-11. PubMed ID: 17634425
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
