225 related articles for article (PubMed ID: 22035802)
1. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks.
Piasecki SK; Taylor CA; Detelich JF; Liu J; Zheng J; Komsoukaniants A; Siegel DR; Keatinge-Clay AT
Chem Biol; 2011 Oct; 18(10):1331-40. PubMed ID: 22035802
[TBL] [Abstract][Full Text] [Related]
2. General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.
Zhang Z; Cepeda AJ; Robles ML; Hirsch M; Kumru K; Zhou JA; Keatinge-Clay AT
Chem Commun (Camb); 2019 Dec; 56(1):157-160. PubMed ID: 31799975
[TBL] [Abstract][Full Text] [Related]
3. Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases.
Zheng J; Keatinge-Clay AT
J Mol Biol; 2011 Jul; 410(1):105-17. PubMed ID: 21570406
[TBL] [Abstract][Full Text] [Related]
4. Molecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity.
Mugnai ML; Shi Y; Keatinge-Clay AT; Elber R
Biochemistry; 2015 Apr; 54(14):2346-59. PubMed ID: 25835227
[TBL] [Abstract][Full Text] [Related]
5. Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.
Annaval T; Paris C; Leadlay PF; Jacob C; Weissman KJ
Chembiochem; 2015 Jun; 16(9):1357-64. PubMed ID: 25851784
[TBL] [Abstract][Full Text] [Related]
6. Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.
Zheng J; Taylor CA; Piasecki SK; Keatinge-Clay AT
Structure; 2010 Aug; 18(8):913-22. PubMed ID: 20696392
[TBL] [Abstract][Full Text] [Related]
7. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.
O'Hare HM; Baerga-Ortiz A; Popovic B; Spencer JB; Leadlay PF
Chem Biol; 2006 Mar; 13(3):287-96. PubMed ID: 16638534
[TBL] [Abstract][Full Text] [Related]
8. Broad substrate specificity of ketoreductases derived from modular polyketide synthases.
Bali S; O'Hare HM; Weissman KJ
Chembiochem; 2006 Mar; 7(3):478-84. PubMed ID: 16453348
[TBL] [Abstract][Full Text] [Related]
9. Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.
Harper AD; Bailey CB; Edwards AD; Detelich JF; Keatinge-Clay AT
Chembiochem; 2012 Oct; 13(15):2200-3. PubMed ID: 22951936
[TBL] [Abstract][Full Text] [Related]
10. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.
Siskos AP; Baerga-Ortiz A; Bali S; Stein V; Mamdani H; Spiteller D; Popovic B; Spencer JB; Staunton J; Weissman KJ; Leadlay PF
Chem Biol; 2005 Oct; 12(10):1145-53. PubMed ID: 16242657
[TBL] [Abstract][Full Text] [Related]
11. Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters.
Oguro S; Akashi T; Ayabe S; Noguchi H; Abe I
Biochem Biophys Res Commun; 2004 Dec; 325(2):561-7. PubMed ID: 15530429
[TBL] [Abstract][Full Text] [Related]
12. Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction.
Piasecki SK; Zheng J; Axelrod AJ; Detelich ME; Keatinge-Clay AT
Proteins; 2014 Sep; 82(9):2067-77. PubMed ID: 24634061
[TBL] [Abstract][Full Text] [Related]
13. Site-Directed Mutagenesis of Modular Polyketide Synthase Ketoreductase Domains for Altered Stereochemical Control.
Drufva EE; Spengler NR; Hix EG; Bailey CB
Chembiochem; 2021 Apr; 22(7):1122-1150. PubMed ID: 33185924
[TBL] [Abstract][Full Text] [Related]
14. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange.
Garg A; Xie X; Keatinge-Clay A; Khosla C; Cane DE
J Am Chem Soc; 2014 Jul; 136(29):10190-3. PubMed ID: 25004372
[TBL] [Abstract][Full Text] [Related]
15. Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides.
Meurer G; Gerlitz M; Wendt-Pienkowski E; Vining LC; Rohr J; Hutchinson CR
Chem Biol; 1997 Jun; 4(6):433-43. PubMed ID: 9224566
[TBL] [Abstract][Full Text] [Related]
16. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
Holzbaur IE; Harris RC; Bycroft M; Cortes J; Bisang C; Staunton J; Rudd BA; Leadlay PF
Chem Biol; 1999 Apr; 6(4):189-95. PubMed ID: 10099131
[TBL] [Abstract][Full Text] [Related]
17. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.
Castonguay R; Valenzano CR; Chen AY; Keatinge-Clay A; Khosla C; Cane DE
J Am Chem Soc; 2008 Sep; 130(35):11598-9. PubMed ID: 18693734
[TBL] [Abstract][Full Text] [Related]
18. Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases.
Bailey CB; Pasman ME; Keatinge-Clay AT
Chem Commun (Camb); 2016 Jan; 52(4):792-5. PubMed ID: 26568113
[TBL] [Abstract][Full Text] [Related]
19. Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB.
Hughes AJ; Keatinge-Clay A
Chem Biol; 2011 Feb; 18(2):165-76. PubMed ID: 21338915
[TBL] [Abstract][Full Text] [Related]
20. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.
Baerga-Ortiz A; Popovic B; Siskos AP; O'Hare HM; Spiteller D; Williams MG; Campillo N; Spencer JB; Leadlay PF
Chem Biol; 2006 Mar; 13(3):277-85. PubMed ID: 16638533
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]