BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 22037469)

  • 1. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.
    Patton GC; Stenmark P; Gollapalli DR; Sevastik R; Kursula P; Flodin S; Schuler H; Swales CT; Eklund H; Himo F; Nordlund P; Hedstrom L
    Nat Chem Biol; 2011 Oct; 7(12):950-8. PubMed ID: 22037469
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.
    Hedstrom L
    Crit Rev Biochem Mol Biol; 2012; 47(3):250-63. PubMed ID: 22332716
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.
    Rosenberg MM; Redfield AG; Roberts MF; Hedstrom L
    J Biol Chem; 2016 Oct; 291(44):22988-22998. PubMed ID: 27613871
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The cystathionine-β-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels.
    Smith S; Boitz J; Chidambaram ES; Chatterjee A; Ait-Tihyaty M; Ullman B; Jardim A
    Mol Microbiol; 2016 Jun; 100(5):824-40. PubMed ID: 26853689
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry.
    Rosenberg MM; Yao T; Patton GC; Redfield AG; Roberts MF; Hedstrom L
    Biochemistry; 2020 Jun; 59(25):2359-2370. PubMed ID: 32479091
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potential of
    Gaiya DD; Muhammad A; Aimola IA; Udu SK; Balarabe SA; Auta R; Ekpa E; Sheyin A
    J Biomol Struct Dyn; 2023; 41(24):14832-14848. PubMed ID: 36866624
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-β-synthase domain.
    Knejzlík Z; Doležal M; Herkommerová K; Clarova K; Klíma M; Dedola M; Zborníková E; Rejman D; Pichová I
    FEBS J; 2022 Sep; 289(18):5571-5598. PubMed ID: 35338694
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
    McMillan FM; Cahoon M; White A; Hedstrom L; Petsko GA; Ringe D
    Biochemistry; 2000 Apr; 39(15):4533-42. PubMed ID: 10758003
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases.
    Riera TV; Wang W; Josephine HR; Hedstrom L
    Biochemistry; 2008 Aug; 47(33):8689-96. PubMed ID: 18642884
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Prosise GL; Luecke H
    J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
    Sintchak MD; Fleming MA; Futer O; Raybuck SA; Chambers SP; Caron PR; Murcko MA; Wilson KP
    Cell; 1996 Jun; 85(6):921-30. PubMed ID: 8681386
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.
    Li J; Wei Z; Zheng M; Gu X; Deng Y; Qiu R; Chen F; Ji C; Gong W; Xie Y; Mao Y
    J Mol Biol; 2006 Feb; 355(5):980-8. PubMed ID: 16359702
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals.
    Bessho T; Okada T; Kimura C; Shinohara T; Tomiyama A; Imamura A; Kuwamura M; Nishimura K; Fujimori K; Shuto S; Ishibashi O; Kubata BK; Inui T
    PLoS Negl Trop Dis; 2016 Jan; 10(1):e0004339. PubMed ID: 26731263
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dynamic Characteristics of Guanosine-5'-monophosphate Reductase Complexes Revealed by High-Resolution
    Rosenberg MM; Redfield AG; Roberts MF; Hedstrom L
    Biochemistry; 2018 Jun; 57(22):3146-3154. PubMed ID: 29547266
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis.
    Gan L; Petsko GA; Hedstrom L
    Biochemistry; 2002 Nov; 41(44):13309-17. PubMed ID: 12403633
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
    Colby TD; Vanderveen K; Strickler MD; Markham GD; Goldstein BM
    Proc Natl Acad Sci U S A; 1999 Mar; 96(7):3531-6. PubMed ID: 10097070
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetic mechanism of human inosine 5'-monophosphate dehydrogenase type II: random addition of substrates and ordered release of products.
    Wang W; Hedstrom L
    Biochemistry; 1997 Jul; 36(28):8479-83. PubMed ID: 9214292
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
    Makowska-Grzyska M; Kim Y; Wu R; Wilton R; Gollapalli DR; Wang XK; Zhang R; Jedrzejczak R; Mack JC; Maltseva N; Mulligan R; Binkowski TA; Gornicki P; Kuhn ML; Anderson WF; Hedstrom L; Joachimiak A
    Biochemistry; 2012 Aug; 51(31):6148-63. PubMed ID: 22788966
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acid-base catalysis in the chemical mechanism of inosine monophosphate dehydrogenase.
    Markham GD; Bock CL; Schalk-Hihi C
    Biochemistry; 1999 Apr; 38(14):4433-40. PubMed ID: 10194364
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells.
    Nakamura H; Natsumeda Y; Nagai M; Takahara J; Irino S; Weber G
    Leuk Res; 1992; 16(6-7):561-4. PubMed ID: 1353130
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.