127 related articles for article (PubMed ID: 22041433)
1. CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors.
Cruzan G; Bus J; Hotchkiss J; Harkema J; Banton M; Sarang S
Regul Toxicol Pharmacol; 2012 Feb; 62(1):214-20. PubMed ID: 22041433
[TBL] [Abstract][Full Text] [Related]
2. Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.
Cruzan G; Bus J; Banton M; Gingell R; Carlson G
Regul Toxicol Pharmacol; 2009 Nov; 55(2):205-18. PubMed ID: 19589367
[TBL] [Abstract][Full Text] [Related]
3. Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors.
Cruzan G; Bus J; Hotchkiss J; Sura R; Moore C; Yost G; Banton M; Sarang S
Regul Toxicol Pharmacol; 2013 Jun; 66(1):24-9. PubMed ID: 23454103
[TBL] [Abstract][Full Text] [Related]
4. Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice.
Carlson GP
Toxicology; 2012 Apr; 294(2-3):104-8. PubMed ID: 22386858
[TBL] [Abstract][Full Text] [Related]
5. Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance.
Cruzan G; Bus JS; Banton MI; Sarang SS; Waites R; Layko DB; Raymond J; Dodd D; Andersen ME
Toxicol Sci; 2017 Oct; 159(2):413-421. PubMed ID: 28962520
[TBL] [Abstract][Full Text] [Related]
6. Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans.
Carlson GP
Toxicology; 2008 Dec; 254(1-2):1-10. PubMed ID: 18951947
[TBL] [Abstract][Full Text] [Related]
7. Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern.
Cruzan G; Bus JS; Andersen ME; Carlson GP; Banton MI; Sarang SS; Waites R
Regul Toxicol Pharmacol; 2018 Jun; 95():17-28. PubMed ID: 29496518
[TBL] [Abstract][Full Text] [Related]
8. Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites.
Harvilchuck JA; Pu X; Klaunig JE; Carlson GP
Toxicology; 2009 Oct; 264(3):171-8. PubMed ID: 19666080
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.
Cruzan G; Harkema JR; Hosako H; Wasil JM; Murray FJ
Regul Toxicol Pharmacol; 2015 Nov; 73(2):501-8. PubMed ID: 26456664
[TBL] [Abstract][Full Text] [Related]
10. Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide.
Carlson GP
Toxicol Lett; 2004 May; 150(3):335-9. PubMed ID: 15110085
[TBL] [Abstract][Full Text] [Related]
11. Ring-oxidized metabolites of styrene contribute to styrene-induced Clara-cell toxicity in mice.
Cruzan G; Carlson GP; Turner M; Mellert W
J Toxicol Environ Health A; 2005 Feb; 68(3):229-37. PubMed ID: 15762181
[TBL] [Abstract][Full Text] [Related]
12. Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites.
Cruzan G; Carlson GP; Johnson KA; Andrews LS; Banton MI; Bevan C; Cushman JR
Regul Toxicol Pharmacol; 2002 Jun; 35(3):308-19. PubMed ID: 12202046
[TBL] [Abstract][Full Text] [Related]
13. In vitro metabolism of styrene to styrene oxide in liver and lung of Cyp2E1 knockout mice.
Carlson G
J Toxicol Environ Health A; 2003 May; 66(9):861-9. PubMed ID: 12746132
[TBL] [Abstract][Full Text] [Related]
14. Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.
Andersen ME; Cruzan G; Black MB; Pendse SN; Dodd DE; Bus JS; Sarang SS; Banton MI; Waites R; Layko DB; McMullen PD
Regul Toxicol Pharmacol; 2018 Jul; 96():153-166. PubMed ID: 29777725
[TBL] [Abstract][Full Text] [Related]
15. Effect of multiple doses of styrene and R-styrene oxide on CC10, bax, and bcl-2 expression in isolated Clara cells of CD-1 mice.
Harvilchuck JA; Carlson GP
Toxicology; 2009 May; 259(3):149-52. PubMed ID: 19428955
[TBL] [Abstract][Full Text] [Related]
16. Comparison of styrene and its metabolites styrene oxide and 4-vinylphenol on cytotoxicity and glutathione depletion in Clara cells of mice and rats.
Harvilchuck JA; Carlson GP
Toxicology; 2006 Oct; 227(1-2):165-72. PubMed ID: 16956708
[TBL] [Abstract][Full Text] [Related]
17. Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice.
Carlson GP
J Toxicol Environ Health; 1997 Aug; 51(5):477-88. PubMed ID: 9233381
[TBL] [Abstract][Full Text] [Related]
18. CC10 mRNA and protein expression in Clara cells of CD-1 mice following exposure to styrene or its metabolites styrene oxide or 4-vinylphenol.
Harvilchuck JA; Zurbrugg RJ; Carlson GP
Toxicol Lett; 2008 Dec; 183(1-3):28-35. PubMed ID: 18926891
[TBL] [Abstract][Full Text] [Related]
19. Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.
Shen S; Li L; Ding X; Zheng J
Chem Res Toxicol; 2014 Jan; 27(1):27-33. PubMed ID: 24320693
[TBL] [Abstract][Full Text] [Related]
20. Metabolism and toxicity of the styrene metabolite 4-vinylphenol in CYP2E1 knockout mice.
Vogie K; Mantick N; Carlson G
J Toxicol Environ Health A; 2004 Jan; 67(2):145-52. PubMed ID: 14675903
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
